Expression of genes encoding IGF1, IGF2, and IGFBPs in blood of obese adolescents with insulin resistance

Ahani N, Karimi Arzenani M, Shirkoohi R, Rokouei M, Alipour Eskandani M, Nikravesh A. Expression of insulin-like growth factor binding protein-2 (IGFBP-2) gene in negative and positive human cytomegalovirus glioblastoma multiforme tissues. Med Oncol 31, 812, 2014.2435276010.1007/s12032-013-0812-424352760Search in Google Scholar

Ando H, Kumazaki M, Motosugi Y, Ushijima K, Maekawa T, Ishikawa E, Fujimura A. Impairment of peripheral circadian clocks precedes metabolic abnormalities in ob/ob mice. Endocrinology 152, 1347–1354, 2011.10.1210/en.2010-106821285316Search in Google Scholar

Auf G, Jabouille A, Delugin M, Guerit S, Pineau R, North S, Platonova N, Maitre M, Favereaux A, Vajkoczy P, Seno M, Bikfalvi A, Minchenko D, Minchenko O, Moenner M. High epiregulin expression in human U87 glioma cells relies on IRE1 alpha and promotes autocrine growth through EGF receptor. BMC Cancer 13, 597, 2013.10.1186/1471-2407-13-597387867024330607Search in Google Scholar

Bass R, Eneli I. Severe childhood obesity: an under-recognised and growing health problem. Postgrad Med J 91, 639–645, 2015.10.1136/postgradmedj-2014-13303326338983Search in Google Scholar

Baxter RC. IGF binding proteins in cancer: mechanistic and clinical insights. Nat Rev Cancer 14, 329–341, 2014.10.1038/nrc37202472242924722429Open DOISearch in Google Scholar

Cai X, Wang L, Wang X, Hou F. Silence of IGFBP7 suppresses apoptosis and epithelial mesenchymal transformation of high glucose induced-podocytes. Exp Ther Med 16, 1095–1102, 2018.30112052Search in Google Scholar

Chen J, Van Gulden S, McGuire TL, Fleming AC, Oka C, Kessler JA, Peng CY. BMP-responsive protease HtrA1 is differentially expressed in astrocytes and regulates astrocytic development and injury response. J Neurosci 38, 3840–3857, 2018.10.1523/JNEUROSCI.2031-17.2018589600029483282Search in Google Scholar

Chevet E, Hetz C, Samali A. Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. Cancer Discov 5, 586–597, 2015.10.1158/2159-8290.CD-14-149025977222Search in Google Scholar

Contois LW, Akalu A, Caron JM, Tweedie E, Cretu A, Henderson T, Liaw L, Friesel R, Vary C, Brooks PC. Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo. Angiogenesis 18, 31–46, 2015.10.1007/s10456-014-9445-2428151225249331Search in Google Scholar

D’Angelo V, Pecoraro G, Indolf P, Iannotta A, Donofrio V, Errico ME, Indolf C, Ramaglia M, Lombardi A, Di Martino M, Gigantino V, Baldi A, Caraglia M, De Luca A, Casale F. Expression and localization of serine protease Htra1 in neuroblastoma: correlation with cellular differentiation grade. J Neurooncol 117, 287–294, 2014.10.1007/s11060-014-1387-424493577Search in Google Scholar

Ding M, Bruick RK, Yu Y. Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling. Nat Cell Biol 18, 319–327, 2016.10.1038/ncb3311500150126854565Open DOISearch in Google Scholar

Doultsinos D, Avril T, Lhomond S, Dejeans N, Guedat P, Chevet E. Control of the Unfolded Protein Response in Health and Disease. SLAS Discov 22, 787–800, 2017.10.1177/247255521770168528453376Search in Google Scholar

Ellis BC, Graham LD, Molloy PL. CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism. Biochim Biophys Acta 1843, 372–386, 2014.10.1016/j.bbamcr.2013.10.01624184209Search in Google Scholar

Ferris SP, Kodali VK, Kaufman RJ. Glycoprotein folding and quality-control mechanisms in protein-folding diseases. Dis Model Mech 7, 331–341, 2014.10.1242/dmm.014589394449324609034Search in Google Scholar

Foulstone EJ, Zeng L, Perks CM, Holly JM. Insulin-like growth factor binding protein 2 (IGFBP-2) promotes growth and survival of breast epithelial cells: novel regulation of the estrogen receptor. Endocrinology 154, 1780–1793, 2013.10.1210/en.2012-197023515291Search in Google Scholar

Gambaro K, Quinn MC, Caceres-Gorriti KY, Shapiro RS, Provencher D, Rahimi K, Mes-Masson AM, Tonin PN. Low levels of IGFBP7 expression in high-grade serous ovarian carcinoma is associated with patient outcome. BMC Cancer 15, 135, 2015.10.1186/s12885-015-1138-825886299438140625886299Open DOISearch in Google Scholar

Ghoshal S, Stevens JR, Billon C, Girardet C, Sitaula S, Leon AS, Rao DC, Skinner JS, Rankinen T, Bouchard C, Nunez MV, Stanhope KL, Howatt DA, Daugherty A, Zhang J, Schuelke M, Weiss EP, Coffey AR, Bennett BJ, Sethupathy P, Burris TP, Havel PJ, Butler AA. Adropin: An endocrine link between the biological clock and cholesterol homeostasis. Mol Metab 8, 51–64, 2018.10.1016/j.molmet.2017.12.002598504129331507Search in Google Scholar

Gokulakrishnan K, Velmurugan K, Ganesan S, Mohan V. Circulating levels of insulin-like growth factor binding protein-1 in relation to insulin resistance, type 2 diabetes mellitus, and metabolic syndrome (Chennai Urban Rural Epidemiology Study 118). Metab Clin Exp 61, 43–46, 2012.10.1016/j.metabol.2011.05.01421741060Search in Google Scholar

Han J, Kaufman RJ. Measurement of the unfolded protein response to investigate its role in adipogenesis and obesity. Methods Enzymol 538, 135–150, 2014.10.1016/B978-0-12-800280-3.00008-624529437Search in Google Scholar

Han S, Li Z, Master LM, Master ZW, Wu A. Exogenous IGFBP-2 promotes proliferation, invasion, and chemoresistance to temozolomide in glioma cells via the integrin β1-ERK pathway. Br J Cancer 111, 1400–1409, 2014.10.1038/bjc.2014.435418385625093489Search in Google Scholar

Han J, Kaufman RJ. The role of ER stress in lipid metabolism and lipotoxicity. J Lipid Res 57, 1329–1338, 2016.2714647910.1194/jlr.R067595495987427146479Search in Google Scholar

Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, Zhang Y, Yates III JR, Itkin-Ansari P, Volkmann N, Kaufman RJ. The IRE1α/XBP1s pathway is essential for the glucose response and protection of β cells. PLoS Biol 13, e1002277, 2015.10.1371/journal.pbio.1002277460742726469762Search in Google Scholar

Hermani A, Shukla A, Medunjanin S, Werner H, Mayer D. Insulin-like growth factor binding protein-4 and -5 modulate ligand-dependent estrogen receptor-alpha activation in breast cancer cells in an IGF-independent manner. Cell Signal 25, 1395–1402, 2013.10.1016/j.cellsig.2013.02.01823499909Open DOISearch in Google Scholar

Holmes KM, Annala M, Chua CY, Dunlap SM, Liu Y, Hugen N, Moore LM, Cogdell D, Hu L, Nykter M, Hess K, Fuller GN, Zhang W. Insulin-like growth factor-binding protein 2-driven glioma progression is prevented by blocking a clinically significant integrin, integrin-linked kinase, and NF-κB network. Proc Natl Acad Sci U S A 109, 3475–3480, 2012.10.1073/pnas.1120375109329532022345562Search in Google Scholar

Huang LE, Cohen AL, Colman H, Jensen RL, Fults DW, Couldwell WT. IGFBP2 expression predicts IDH-mutant glioma patient survival. Oncotarget 8, 191–202, 2017.2785204810.18632/oncotarget.13329535210627852048Search in Google Scholar

Hwang JR, Cho YJ, Lee Y, Park Y, Han HD, Ahn HJ, Lee JH, Lee JW. The C-terminus of IGFBP-5 suppresses tumor growth by inhibiting angiogenesis. Sci Rep 23, 39334, 2016.10.1038/srep39334518024528008951Search in Google Scholar

Kim MS, Lee DY. Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus. Ann Pediatr Endocrinol Metab 20, 69–73, 2015.10.6065/apem.2015.20.2.69450499226191509Search in Google Scholar

Kuffer S, Gutting T, Belharazem D, Sauer C, Michel MS, Marx A, Trojan L, Strobel P. Insulin-like growth factor 2 expression in prostate cancer is regulated by promoter-specific methylation. Mol Oncol 12, 256–266, 2018.10.1002/1878-0261.1216429239100579273529239100Open DOISearch in Google Scholar

Kuijjer ML, Peterse EF, van den Akker BE, Briaire-de Bruijn IH, Serra M, Meza-Zepeda LA, Myklebost O, Hassan AB, Hogendoorn PC, Cleton-Jansen AM. IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma. BMC Cancer 13, 245, 2013.10.1186/1471-2407-13-245367200723688189Search in Google Scholar

Lee J, Ozcan U. Unfolded protein response signaling and metabolic diseases. J Biol Chem 289, 1203–1211, 2014.10.1074/jbc.R113.534743389430624324257Search in Google Scholar

Li X, Liu X, Zhang L, Li C, Zhang E, Ma W, Fan Q, Yu JJ. Insulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis. Oncotarget 8, 36628–36638, 2017.2841023010.18632/oncotarget.16695548268228410230Search in Google Scholar

Liu L, Yang Z, Zhang W, Yan B, Gu Q, Jiao J, Yue X. Decreased expression of IGFBP7 was a poor prognosis predictor for gastric cancer patients. Tumour Biol 35, 8875–8881, 2014.2489467410.1007/s13277-014-2160-124894674Search in Google Scholar

Lopez MF, Zheng L, Miao J, Gali R, Gorski G, Hirschhorn JN. Disruption of the Igf2 gene alters hepatic lipid homeostasis and gene expression in the newborn mouse. Am J Physiol Endocrinol Metab 2018.10.1152/ajpendo.00048.201830016152629317230016152Open DOISearch in Google Scholar

Mao Z, Zhang W. Role of mTOR in glucose and lipid metabolism. Int J Mol Sci 19, pii: E2043, 2018.10.3390/ijms19072043607376630011848Open DOISearch in Google Scholar

Maridas DE, DeMambro VE, Le PT, Mohan S, Rosen CJ. IGFBP4 is required for adipogenesis and influences the distribution of adipose depots. Endocrinology 158, 3488–3500, 2017.10.1210/en.2017-00248565970428938423Search in Google Scholar

Manie SN, Lebeau J, Chevet E. Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: an update. Am J Physiol Cell Physiol 307, C901–C907, 2014.10.1152/ajpcell.00292.201425186011Search in Google Scholar

Martin KA, Mani MV, Mani A. New targets to treat obesity and the metabolic syndrome. Eur J Pharmacol 763, 64–74, 2015.10.1016/j.ejphar.2015.03.093457331726001373Search in Google Scholar

Minchenko OH, Kubaichuk KI, Minchenko DO, Kovalevska OV, Kulinich AO, Lypova NM. Molecular mechanisms of ERN1-mediated angiogenesis. Int J Physiol Pathophysiol 5, 1–22, 2014.10.1615/IntJPhysPathophys.v5.i1.10Search in Google Scholar

Minchenko DO, Kharkova AP, Karbovskyi LL, Minchenko OH. Expression of insulin-like growth factor binding protein genes and its hypoxic regulation in U87 glioma cells depends on ERN1 mediated signaling pathway of endoplasmic reticulum stress. Endocr Regul 49, 73–83, 2015a.10.4149/endo_2015_02_7325960008Search in Google Scholar

Minchenko OH, Tsymbal DO, Minchenko DO, Moenner M, Kovalevska OV, Lypova NM: Inhibition of the endoribonuclease of ERN1 signaling enzyme affects the expression of proliferation-related genes in U87 glioma cells. Endoplasm Reticul Stress Dis 2, 18–29, 2015b.10.1515/ersc-2015-0002Search in Google Scholar

Minchenko DO, Kharkova AP, Halkin OV, Karbovskyi LL, Minchenko OH. Effect of hypoxia on the expression of genes encoded insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function. Endocr Reg 50, 43–54, 2016.10.1515/enr-2016-000827560636Search in Google Scholar

Neuzillet Y, Chapeaublanc E, Krucker C, De Koning L, Lebret T, Radvanyi F, Bernard-Pierrot I. IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancer. BMC Cancer 17, 636, 2017.10.1186/s12885-017-3618-5558874228882129Open DOISearch in Google Scholar

Ord T, Ord D, Adler P, Vilo J, Ord T. TRIB3 enhances cell viability during glucose deprivation in HEK293-derived cells by upregulating IGFBP2, a novel nutrient deficiency survival factor. Biochim Biophys Acta 1853, 2492–2505, 2015.10.1016/j.bbamcr.2015.06.00626094770Search in Google Scholar

Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306, 457–461, 2004.10.1126/science.110316015486293Search in Google Scholar

Peng T, Zhou L, Qi H, Wang G, Luan Y, Zuo L. MiR-592 functions as a tumor suppressor in glioma by targeting IGFBP2. Tumour Biol 39, 1010428317719273, 2017.10.1177/101042831771927328718372Search in Google Scholar

Poepsel S, Sprengel A, Sacca B, Kaschani F, Kaiser M, Gatsogiannis C, Raunser S, Clausen T, Ehrmann M. Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nat Chem Biol 11, 862–869, 2015.10.1038/nchembio.193126436840Search in Google Scholar

Pollak M. The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer 12, 159–169, 2012.10.1038/nrc32152233714922337149Open DOISearch in Google Scholar

Praveen Kumar VR, Sehgal P, Thota B, Patil S, Santosh V, Kondaiah P. Insulin like growth factor binding protein 4 promotes GBM progression and regulates key factors involved in EMT and invasion. J Neurooncol 116, 455–464, 2014.10.1007/s11060-013-1324-y24395346Search in Google Scholar

Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest, 123, 2764–2772, 2013.10.1172/JCI67227369653923863634Search in Google Scholar

Sabin MA, Russo VC, Azar WJ, Yau SW, Kiess W, Werther GA: IGFBP-2 at the interface of growth and metabolism implications for childhood obesity. Pediatr Endocrinol Rev 8, 382–393, 2011.Search in Google Scholar

Schillinger J, Severin K, Kaschani F, Kaiser M, Ehrmann M. HTRA1-Dependent Cell Cycle Proteomics. J Proteome Res 17, 2679–2694, 2018.10.1021/acs.jproteome.8b0012929863874Search in Google Scholar

Shimba S, Ogawa T, Hitosugi S, Ichihashi Y, Nakadaira Y, Kobayashi M, Tezuka M, Kosuge Y, Ishige K, Ito Y, Komiyama K, Okamatsu-Ogura Y, Kimura K, Saito M. Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One 6, e25231, 2011.10.1371/journal.pone.0025231317862921966465Search in Google Scholar

Sun J, Lu Z, Deng Y, Wang W, He Q, Yan W, Wang A. Up-regulation of INSR/IGF1R by C-myc promotes TSCC tumorigenesis and metastasis through the NF-kappaB pathway. Biochim Biophys Acta 1864, 1873–1882, 2018.10.1016/j.bbadis.2018.03.00429518496Search in Google Scholar

Sunderic M, Dukanovic B, Malenkovic V, Nedic O. Molecular forms of the insulin-like growth factor-binding protein-2 in patients with colorectal cancer. Exp Mol Pathol 96, 48–53, 2014.10.1016/j.yexmp.2013.11.0062427543024275430Open DOISearch in Google Scholar

Tam J, Szanda G, Drori A, Liu Z, Cinar R, Kashiwaya Y, Reitman ML, Kunos G. Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling. Mol Metab 6, 1113–1125, 2017.10.1016/j.molmet.2017.06.010564162829031713Search in Google Scholar

Tang H, Leung L, Saturno G, Viros A, Smith D, Di Leva G, Morrison E, Niculescu-Duvaz D, Lopes F, Johnson L, Dhomen N, Springer C, Marais R. Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface. Nat Commun 8, 14909, 2017.10.1038/ncomms14909539928728416796Search in Google Scholar

Tiaden AN, Bahrenberg G, Mirsaidi A, Glanz S, Bluher M, Richards PJ. Novel function of serine protease HTRA1 in inhibiting adipogenic differentiation of human mesenchymal stem cells via MAP Kinase-mediated MMP upregulation. Stem Cells 34, 1601–1614, 2016.10.1002/stem.229726864869Search in Google Scholar

Tsuchihara K, Ogura T, Fujioka R, Fujii S, Kuga W, Saito M, Ochiya T, Ochiai A, Esumi H. Susceptibility of Snark-deficient mice to azoxymethaneinduced colorectal tumorigenesis and the formation of aberrant crypt foci. Cancer Sci 99, 677–682, 2008.10.1111/j.1349-7006.2008.00734.x18307533Search in Google Scholar

Wang S, Kaufman RJ. The impact of the unfolded protein response on human disease. J Cell Biol 197, 857–867, 2012.10.1083/jcb.201110131338441222733998Search in Google Scholar

Wang J, Ding N, Li Y, Cheng H, Wang D, Yang Q, Deng Y, Yang Y, Li Y, Ruan X, Xie F, Zhao H, Fang X. Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells. Oncotarget 6, 20636–20649, 2015.10.18632/oncotarget.4114465303126010068Search in Google Scholar

Wang M, Kaufman RJ. Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature 529, 326–335, 2016.10.1038/nature1704126791723Search in Google Scholar

Yang B, Zhang L, Cao Y, Chen S, Cao J, Wu D, Chen J, Xiong H, Pan Z, Qiu F, Chen J, Ling X, Yan M, Huang S, Zhou S, Li T, Yang L, Huang Y, Lu J. Overexpression of lncRNA IGFBP4-1 reprograms energy metabolism to promote lung cancer progression. Mol Cancer 16, 154, 2017.10.1186/s12943-017-0722-8561338628946875Open DOISearch in Google Scholar

Yuan ZS, Cao Y, Li ZY. IGFBP2 induces SPRY1 expression via NF-kappaB signaling pathway in glioblastoma multi-forme (GBM). Eur Rev Med Pharmacol Sci 21, 5072–5080, 2017.Search in Google Scholar

Yuzefovych LV, Musiyenko SI, Wilson GL, Rachek LI. Mitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein degradation and apoptosis in high fat diet-induced insulin resistance mice. PLoS One 8, e54059, 2013.10.1371/journal.pone.0054059354697323342074Search in Google Scholar

Zurawa-Janicka D, Wenta T, Jarzab M, Skorko-Glonek J, Glaza P, Gieldon A, Ciarkowski J, Lipinska B. Structural insights into the activation mechanisms of human HtrA serine proteases. Arch Biochem Biophys 621, 6–23, 2017.10.1016/j.abb.2017.04.00428396256Search in Google Scholar