The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3-yl)thio) acetate substance

1. Blumenthal GM, Goldberg KB, Pazdur R. Drug development, trial design, and endpoints in oncology: adapting to rapidly changing science. Clinical Pharmacology & Therapeutics. 2017;101:572-4.10.1002/cpt.62328074476Search in Google Scholar

2. Dimitrios Z, Pridgen CS, Vincenzo L. Process development and robust control of physical attributes of an amorphous drug substance. Journal of Pharmaceutical Sciences. 2018;107:217-30.10.1016/j.xphs.2017.09.01028947338Search in Google Scholar

3. Sandeep S, Vohora D. Drug discovery and development: An overview. Pharmaceutical Medicine and Translational Clinical Research. 2018;19:19-32.10.1016/B978-0-12-802103-3.00002-XSearch in Google Scholar

4. Bulut N, Kocyigit UM, Gecibesler IH, Dastan T, Karci H, Taslimi P et al. Synthesis of some novel pyridine compounds containing bis 1,2,4-triazole/thiosemicarbazide moiety and investigation of their antioxidant properties, carbonic anhydrase, and acetylcholinesterase enzymes inhibition profiles. Journal of Biochemical and Molecular Toxicology. 2018;32: 1-10.10.1002/jbt.2200629131470Search in Google Scholar

5. Kumar R, Shahar Yar M, Chaturvedi S, Srivastava A. Triazole as pharmaceuticals potentials. Int. J. pharm. Tech. Res. 2013;5:1844-69.Search in Google Scholar

6. El-Gazzar YI, Georgey HH, El-Messery SM, Ewida HA, Hassan GS, Raafat MM, et al. Synthesis, biological evaluation and molecular modeling study of new (1,2,4-triazole or 1,3,4-thiadiazole)-methylthio-derivatives of quinazolin-4(3H)-one as DHFR inhibitors. Bioorganic Chemistry. 2017; 72: 282-92.10.1016/j.bioorg.2017.04.01928499189Search in Google Scholar

7. Shcherbyna RO, Danilchenko DM, Parchenko VV, Panasenko OI, Knysh EH, Hromyh NA, et al. Studying of 2-((5-R-4-R1-4H-1,2,4-triazole-3-yl)thio)acetic acid salts influence on growth and progress of blackberries (KIOWA Variety) propagules. Res. J. Pharm., Biol. Chem. Sci. 2017;8: 975-9.Search in Google Scholar

8. Singala P, Talpara P. Synthesis of new 1,2,4-triazole derivatives and their antimicrobial screening. International Journal of Scientific Research in Science, Engineering and Technology. 2017;3:1009-12.Search in Google Scholar

9. Shcherbyna RO, Samura TO, Kyrychko BP, Zvenihorodska TV, Hyrenko IV. The research of ammonium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate (PKR-177) influence on biochemical indices in rats blood under hepatitis initiated by tetrachloride methane. Zaporozhye Medical Journal. 2017; 19:819-22.10.14739/2310-1210.2017.6.115304Search in Google Scholar

10. Shcherbyna RO, Panasenko OI, Knysh YG, Fotina HA, Vashchyk YV, Fotina TI. The study of antimicrobial activity of 2-((4-R-3-(morpholinomethylene)-4H-1,2,4-triazole-5-yl)thio)acetic acid salts. Zaporozhye Medical Journal. 2016;4:97-0.10.14739/2310-1210.2016.4.79775Search in Google Scholar

11. Shcherbyna RO, Panasenko OI, Knysh YeH. The studying of antioxidant activity of salts 2-((4-R-3-(morpholinomethylen)-4H-1,2,4-triazole-5-yl)thio)acetic acids. Ukraïns’kij Bìofarmacevtičnij Žurnal. 2016;42: 37-0.10.24959/ubphj.16.7Search in Google Scholar

12. Anderson J, Gerlin M, Sversut R, Oliveira L, Singh A, Amaral M et al. Development and validation of an isocratic HPLC method for simultaneous determination of quaternary mixtures of antihypertensive drugs in pharmaceutical formulations. Acta Chromatographica. 2017;29:95-10.10.1556/1326.2017.29.1.9Search in Google Scholar

13. Baker M, El-Kafrawy D, Mahrous M, Belal T. Validated stability-indicating HPLC-DAD method for determination of the recently approved hepatitis C antiviral agent daclatasvir. Annales Pharmaceutiques Françaises. 2017;75:176-4.10.1016/j.pharma.2016.12.00528187879Search in Google Scholar

14. Pavlović D, Babić S, Horvat A, Kaštelan-Macan M. Sample preparation in analysis of pharmaceuticals. TrAC Trends in Analytical Chemistry. 2007;26:1062-5.10.1016/j.trac.2007.09.010Search in Google Scholar

15. Shcherbyna RO. Synthesis, physical and chemical properties of 2-((4-R-3-(morfolinomethylen)-4H-1,2,4-triazole-5-yl)thio)acetic acid salts. Current issues in pharmacy and medicine: science and practice. 2017;10: 4-8.10.14739/2409-2932.2017.1.93424Search in Google Scholar

16. State Pharmacopoeia of Ukraine. 1^st ed. Kharkiv: DP “Naukovoekspertnii farmakopeinii tsentr”;2001:538.Search in Google Scholar

17. State Pharmacopoeia of Ukraine. Supplement 1. 2^nd ed. Kharkiv: RIREKH; 2004: 494.Search in Google Scholar

18. European pharmacopoeia. Strasbourg: Council of Europe; 2016Search in Google Scholar

19. Direct injection electrospray mass spectrometry using Agilent 1100 Series LC-MS [Internet]. Haverford; 2018 [cited 29 March 2018]. Available from: https://www.haverford.edu/sites/default/files/Department/Chemistry/Agilent%20Direct%20Inject.pdfSearch in Google Scholar