<abstract xmlns="http://www.w3.org/1999/xhtml">

<p> The paper describes the influence of oral administration of methimazole on biophysical skin parameters. Wistar rats of different sex (220-260 g) were used in the experiment. Biophysical skin parameters, such as transepidermal water loss (TEWL), corneometry, and pH were examined at seven-day intervals. Significant changes in the parameters were observed on the 7<sup>th</sup> d of methimazole administration. The changes were observed in both sex but males appeared to be less sensitive in that respect. Changes in the parameters in the females showed rapid mechanisms, which normalised transepidermal water loss and skin hydration, as well as restored skin barrier functions. TEWL, skin hydration, and skin pH measurements allow an early assessment of skin barrier dysfunction after administration of this drug.</p>
</abstract>

The paper describes the influence of oral administration of methimazole on biophysical skin parameters. Wistar rats of different sex (220-260 g) were used in the experiment. Biophysical skin parameters, such as transepidermal water loss (TEWL), corneometry, and pH were examined at seven-day intervals. Significant changes in the parameters were observed on the 7th d of methimazole administration. The changes were observed in both sex but males appeared to be less sensitive in that respect. Changes in the parameters in the females showed rapid mechanisms, which normalised transepidermal water loss and skin hydration, as well as restored skin barrier functions. TEWL, skin hydration, and skin pH measurements allow an early assessment of skin barrier dysfunction after administration of this drug.

Biophysical parameters of rats’ skin after the administration of methimazole

Sub-Department of Internal Diseases of Farm Animals and Horses

Sub-Department of Clinical Diagnostics and Veterinary Dermatology

Department and Clinic of Veterinary Surgery Faculty of Veterinary Medicine

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The paper describes the influence of oral administration of methimazole on biophysical skin parameters. Wistar rats of different sex (220-260 g) were used in...

Biophysical parameters of rats’ skin after the administration of methimazole

Data publikacji: 17 cze 2014

Zakres stron: 315 - 319

Otrzymano: 04 wrz 2013

Przyjęty: 06 cze 2014

DOI: https://doi.org/10.2478/bvip-2014-0049

Słowa kluczowe
skin, methimazole, transepidermal water loss, corneometry, pH.

© 2014 National Veterinary Research Institute in Pulawy

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Biophysical parameters of rats’ skin after the administration of methimazole

Data publikacji: 17 cze 2014

Zakres stron: 315 - 319

Otrzymano: 04 wrz 2013

Przyjęty: 06 cze 2014

DOI: https://doi.org/10.2478/bvip-2014-0049

Słowa kluczoweskin, methimazole, transepidermal water loss, corneometry, pH.

© 2014 National Veterinary Research Institute in Pulawy

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Słowa kluczowe
skin, methimazole, transepidermal water loss, corneometry, pH.