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Associations between vaspin rs2236242 gene polymorphism, walking time and the risk of metabolic syndrome

E Suliga
E Suliga
, 
D Kozieł
D Kozieł
, 
E Cieśla
E Cieśla
, 
D Rębak
D Rębak
, 
M Wawszczak
M Wawszczak
, 
W Adamus-Białek
W Adamus-Białek
, 
E Naszydłowska
E Naszydłowska
, 
A Piechowska
A Piechowska
 oraz 
S Głuszek
S Głuszek
   | 28 sie 2019
Balkan Journal of Medical Genetics's Cover Image
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Article Category: Original Article
Data publikacji: 28 sie 2019
Zakres stron: 41 - 48
DOI: https://doi.org/10.2478/bjmg-2019-0013
Słowa kluczowe
© 2019 Suliga E, Kozieł D, Cieśla E, Rębak D, Wawszczak M, Adamus-Białek W, Naszydłowska E, Piechowska A, Głuszek S, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Electrophoresis patterns of T-ARMS PCR for the detection of SNPs in vaspin rs2236242. The product sizes were 174 bp for Τ allele, 248 bp for A allele, and 378 bp for control. M; DNA marker.
Electrophoresis patterns of T-ARMS PCR for the detection of SNPs in vaspin rs2236242. The product sizes were 174 bp for Τ allele, 248 bp for A allele, and 378 bp for control. M; DNA marker.

Figure 2

Schematic diagram for 14 variables; linkage distances.
Schematic diagram for 14 variables; linkage distances.

The meta-analysis of the the vaspin rs2236242 polymorphism in the MetS patients (n = 469) and the control group (n = 459) from Iran, Egypt and Poland.

GenotypesMetS Patients n (%)Control Group n (%)χ2(df=2)ρ Value
TT210 (44.78)149 (32.46)
TA215 (45.84)240 (52.59)24.20<0.0001
AA34 (7.25)70 (15.25)
Allelesχ2(df=l)ρ Value
Τ635 (67.70)538 (58.61)33.21<0.0001
A283 (30.17)380 (41.39)

Associations between the vaspin rs2236242 polymorphism a risk of MetS and its components [OR (95% CI)]. I: unadjusted model; II: model adjusted for gender, age, smoking, walking and interactions between the vaspin rs2236242 polymorphism and walking in relation to MetS and its components; III: model adjusted for gender, age, smoking, BMI, walking and interactions between the vaspin rs2236242 gene polymorphism and walking in relation to MetS or its components.

Components of MetSAA (TTref.)ρ ValueTA (TT ret)p ValueTA+AA (TTref.)ρ ValueAA (TT+TAref.)p Value
MetSI0.54 (0.22-1.35)0.1870.15 (0.65-2.02)0.6380.99 (0.58-1.71)0.9790.50(0.21-1.18)0.115
II1.24(0.31-4.97)0.7592.54 (1.07-60.5)a0.0352.14 (0.96-4.77)·0.0640.75 (0.20-2.83)0.674
III0.91 (0.19-4.360.9112.96 (1.07-7.40)a0.0202.37 (1.01-5.57)·0.0470.60 (0.14-2.48)0.480
Abdominal obesityI0.80 (0.32-2.04)0.6471.13 (0.60-2.12)0.6991.05 (0.58-1.91)0.8610.75 (0.32-1.79)0.521
II1.61 (0.28-9.36)0.5930.91 (0.34-2.43)0.8461.02 (0.40-2.62)0.9611.41 (0.26-7.72)0.695
III1.21 (0.11-12.77)0.8741.84 (0.45-7.57)0.3981.59 (0.43-5.09)0.4830.50 (0.07-3.78)0.506
Elevated BPI0.71 (0.26-1.94)0.5030.89 (0.45-1.78)0.7440.85 (0.44-1.64)0.6270.75 (0.30-1.92)0.554
II0.60 (0.20-1.77)0.3561.88 (0.64-5.52)b0.2512.38 (0.84-6.77)»0.1030.61 (0.23-1.64)0.332
III0.44 (0.13-1.49)0.1871.86 (0.63-7.04)b0.2652.42 (0.83-7.04)»0.1040.62 (0.22-1.72)0.360
Increased glucoseI0.80(0.31-2.06)0.6481.14 (0.63-2.05)0.6631.07 (0.61-1.87)0.8230.75 (0.41-1.80)0.517
concentrationII1.02 (0.24-4.33)0.9780.41 (0.60-3.30)0.4241.30 (0.58-2.91)0.5270.76 (0.19-2.97)0.696
III0.78 (0.17-3.58)0.7481.46 (0.61-3.47)0.3951.29 (0.56 (2.96)0.5440.65 (0.16-2.62)0.546
Decreased HDLI0.56 (0.19-1.64)0.2901.06 (0.57-1.96)0.8520.95 (0.52-1.172)0.8610.54 (0.19-1.50)0.238
concentrationII1.44(0.31-4.78)0.6421.84 (0.74-4.60)0.1891.72 (0.72-4.11)0.2191.10 (0.26-4.67)0.899
III1.26 (0.25-6.21)0.7781.91 (0.76-4.79)0.1701.72 (0.71-4.16)0.2240.99 (0.22-4.36)0.990
Increased TGI0.60 (0.22-1.66)0.3241.42 (0.79-2.56)0.2451.22 (0.69-2.15)0.4930.49 (0.19-1.28)0.148
concentrationII2.34 (0.57-9.64)c0.2372.02 (0.854.78)0.1102.09 (0.92-4.75)0.0761.66 (0.44-6.24)c0.456
III1.92 (0.42-8.09)c0.3992.12 (0.88-5.11)0.0952.15 (0.93-5.00)0.0751.49 (0.37-5.97)c0.569

Genolype and allele distribution of the vaspin rs2236242 polymorphism in the control group and MetS patients.

GenotypesTotal n(%)Control Group n (%)MetS Patients n (%)χ2(df=2)p Value
TT86 (39.45)43 (39.10)43 (39.81)
TA106 (48.62)50 (45.45)56 (51.86)2.7830250
AA26 (11.93)17(15.45)9 (8.33)
Allelesχ2 (df = 1)ρ Value
Τ278 (63.76)126 (61.82)142 (65.74)0.7300.394
A158 (36.24)84 (38.18)74 (34.26)
eISSN:
1311-0160
Język:
Angielski
Częstotliwość wydawania:
2 razy w roku
Dziedziny czasopisma:
Medicine, Basic Medical Science, other
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