<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The aim of this study was to investigate radioprotective properties of <italic>Echinacea purpurea</italic> tablets <italic>in vivo</italic>. We analysed lymphocyte chromosome aberrations (CA), micronuclei (MN), apoptosis of leukocytes and haematological parameters in a group of radiation workers who were identified as carrying dicentric chromosomes in their lymphocytes. All radiation workers were taking two 275 mg Echinacea tablets <italic>b.i.d.</italic>, according to a pharmacist's recommendation. All parameters were analysed before and after the two-week treatment. At the end of the treatment lymphocyte CA frequency dropped significantly, and the number of apoptotic cells increased. The inverse lymphocyte-to-granulocyte ratio at the beginning of the study changed to normal at its end. In conclusion, biological effects observed after administration of <italic>Echinacea purpurea</italic> preparation suggest that it may be beneficial for the prevention of adverse health effects in workers exposed to ionising radiation.</p></abstract>

The aim of this study was to investigate radioprotective properties of Echinacea purpurea tablets in vivo. We analysed lymphocyte chromosome aberrations (CA), micronuclei (MN), apoptosis of leukocytes and haematological parameters in a group of radiation workers who were identified as carrying dicentric chromosomes in their lymphocytes. All radiation workers were taking two 275 mg Echinacea tablets b.i.d., according to a pharmacist's recommendation. All parameters were analysed before and after the two-week treatment. At the end of the treatment lymphocyte CA frequency dropped significantly, and the number of apoptotic cells increased. The inverse lymphocyte-to-granulocyte ratio at the beginning of the study changed to normal at its end. In conclusion, biological effects observed after administration of Echinacea purpurea preparation suggest that it may be beneficial for the prevention of adverse health effects in workers exposed to ionising radiation.

Biological Effects of <italic>Echinacea Purpurea</italic> on Human Blood Cells

Vinča Institute of Nuclear Sciences, Belgrade, Serbia

Clinic of Gynecology and Obstetrics "Narodni Front", Belgrade, Serbia

Archives of Industrial Hygiene and Toxicology

Biological Effects of  on Human Blood Cells

The aim of this study was to investigate radioprotective properties of Echinacea purpurea tablets in vivo. We analysed lymphocyte chromosome aberrations (CA),...

Biological Effects of Echinacea Purpurea on Human Blood Cells

Data publikacji: 06 lip 2009

Zakres stron: 165 - 172

DOI: https://doi.org/10.2478/10004-1254-60-2009-1920

Słowa kluczowe
apoptosis, ionising radiation, micronuclei, protective effects

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