<abstract xmlns="http://www.w3.org/1999/xhtml"><p> TP 53 promoter methylation was examined in frozen tumor tissue taken from patients with oropharyngeal carcinoma with EBV, HPV and co-infection EBV/HPV. This pilot study was performed on 48 patients. Initial studies indicate a high frequency of methylation in HPV-associated (57.1%) and EBV - associated OSCC (60%) cases, whilst the highest exists in co-infection HPV/EBV (75%). Future studies on a larger group of patients, of the mechanisms of co-infection and their role in oral squamous cell carcinoma, are necessary.</p></abstract>

TP 53 promoter methylation was examined in frozen tumor tissue taken from patients with oropharyngeal carcinoma with EBV, HPV and co-infection EBV/HPV. This pilot study was performed on 48 patients. Initial studies indicate a high frequency of methylation in HPV-associated (57.1%) and EBV - associated OSCC (60%) cases, whilst the highest exists in co-infection HPV/EBV (75%). Future studies on a larger group of patients, of the mechanisms of co-infection and their role in oral squamous cell carcinoma, are necessary.

TP53 promoter methylation in EBV and HPV associated oropharyngeal carcinoma – a pilot study

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

TP 53 promoter methylation was examined in frozen tumor tissue taken from patients with oropharyngeal carcinoma with EBV, HPV and co-infection EBV/HPV. This...

TP53 promoter methylation in EBV and HPV associated oropharyngeal carcinoma – a pilot study

Data publikacji: 29 gru 2017

Zakres stron: 119 - 122

Otrzymano: 26 cze 2017

Przyjęty: 29 lip 2017

DOI: https://doi.org/10.1515/cipms-2017-0021

Słowa kluczowe
TP53, methylation, OSCC, EBV, HPV

© 2018

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

TP53 promoter methylation in EBV and HPV associated oropharyngeal carcinoma – a pilot study

Data publikacji: 29 gru 2017

Zakres stron: 119 - 122

Otrzymano: 26 cze 2017

Przyjęty: 29 lip 2017

DOI: https://doi.org/10.1515/cipms-2017-0021

Słowa kluczoweTP53, methylation, OSCC, EBV, HPV

© 2018

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Słowa kluczowe
TP53, methylation, OSCC, EBV, HPV