<abstract xmlns="http://www.w3.org/1999/xhtml"><sec><h3>Background</h3><p>In the aging individuals, osteoporosis is a major health problem. Due to the various limitations of dual X-ray absorptiometry (DEXA) for diagnosis osteoporosis, serum-based biochemical markers have been suggested for the discrimination between the patients and healthy subjects.</p></sec><sec><h3>Objective</h3><p>To investigate the serum levels of bone turnover markers in elderly osteoporosis patients.</p></sec><sec><h3>Methods</h3><p>The serum samples from elderly subjects (osteoporosis (n = 28), osteopenia (n = 28), and healthy ones (n = 28) were collected from Amirkola Health and Ageing Project study. Furthermore, serum levels of bone formation and bone resorption markers as well as estrogen and progesterone were measured by enzyme-linked immunosorbent assay. Kruskal–Wallis test and receiver operating characteristic curve analysis were used for statistical analysis using SPSS.</p></sec><sec><h3>Results</h3><p>Levels of bone alkaline phosphatase (B-ALP) and procollagen type I N-terminal propeptide (PINP) differed between groups (<italic>P</italic> = 0.003 and 0.009, respectively). Furthermore, PINP and B-ALP levels had the best area under the curve, sensitivity, and specificity for the discrimination between patients with osteoporosis and healthy individuals.</p></sec><sec><h3>Conclusion</h3><p>In conditions in which we are not able to assess the bone mineral density by DEXA, analysis of the B-ALP and PINP levels may be a helpful tool.</p></sec></abstract>

BackgroundIn the aging individuals, osteoporosis is a major health problem. Due to the various limitations of dual X-ray absorptiometry (DEXA) for diagnosis osteoporosis, serum-based biochemical markers have been suggested for the discrimination between the patients and healthy subjects.ObjectiveTo investigate the serum levels of bone turnover markers in elderly osteoporosis patients.MethodsThe serum samples from elderly subjects (osteoporosis (n = 28), osteopenia (n = 28), and healthy ones (n = 28) were collected from Amirkola Health and Ageing Project study. Furthermore, serum levels of bone formation and bone resorption markers as well as estrogen and progesterone were measured by enzyme-linked immunosorbent assay. Kruskal–Wallis test and receiver operating characteristic curve analysis were used for statistical analysis using SPSS.ResultsLevels of bone alkaline phosphatase (B-ALP) and procollagen type I N-terminal propeptide (PINP) differed between groups (P = 0.003 and 0.009, respectively). Furthermore, PINP and B-ALP levels had the best area under the curve, sensitivity, and specificity for the discrimination between patients with osteoporosis and healthy individuals.ConclusionIn conditions in which we are not able to assess the bone mineral density by DEXA, analysis of the B-ALP and PINP levels may be a helpful tool.

Status of circulating bone turnover markers in elderly osteoporosis/osteopenia patients in comparison with healthy subjects

Department of Clinical Biochemistry, School of Medicine

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

BackgroundIn the aging individuals, osteoporosis is a major health problem. Due to the various limitations of dual X-ray absorptiometry (DEXA) for diagnosis...

Status of circulating bone turnover markers in elderly osteoporosis/osteopenia patients in comparison with healthy subjects

Article Category: Original article

Data publikacji: 10 wrz 2020

Zakres stron: 97 - 106

DOI: https://doi.org/10.1515/abm-2020-0015

Słowa kluczowe
bone density, bone remodeling, osteoporosis

© 2020 Sadra Samavarchi Tehrani et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Status of circulating bone turnover markers in elderly osteoporosis/osteopenia patients in comparison with healthy subjects

Article Category: Original article

Data publikacji: 10 wrz 2020

Zakres stron: 97 - 106

DOI: https://doi.org/10.1515/abm-2020-0015

Słowa kluczowebone density, bone remodeling, osteoporosis

© 2020 Sadra Samavarchi Tehrani et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Słowa kluczowe
bone density, bone remodeling, osteoporosis