This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [online] 2013. [cited on 2016 Jan 15]. Available from: http://globocan.iarc.frFerlayJSoerjomataramIErvikMDikshitREserSMathersCet alcited on2016Jan15Available fromhttp://globocan.iarc.frSearch in Google Scholar
Nguyen VT, Law MG, Dore GJ. Hepatitis B-related hepatocellular carcinoma: epidemiological characteristics and disease burden. J Viral Hepat. 2009; 16:453-63.NguyenVTLawMGDoreGJHepatitis B-related hepatocellular carcinoma: epidemiological characteristics and disease burden2009164536310.1111/j.1365-2893.2009.01117.xSearch in Google Scholar
McGlynn KA, London WT. The global epidemiology of hepatocellular carcinoma: present and future. Clin Liver Dis. 2011; 15:223-43, vii-x.McGlynnKALondonWTThe global epidemiology of hepatocellular carcinoma: present and future201115223–43viix10.1016/j.cld.2011.03.006Search in Google Scholar
Fattovich G, Bortolotti F, Donato F. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors. J Hepatol. 2008; 48:335-52.FattovichGBortolottiFDonatoFNatural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors2008483355210.1016/j.jhep.2007.11.011Search in Google Scholar
Yang HI, Yuen MF, Chan HL, Han KH, Chen PJ, Kim D Y, et al. Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score. Lancet Oncol. 2011; 12:568-74.YangHIYuenMFChanHLHanKHChenPJKimD Yet alRisk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score2011125687410.1016/S1470-2045(11)70077-8Search in Google Scholar
Loomba R, Liu J, Yang HI, Lee MH, Lu SN, Wang LY, et al. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. Clin Gastroenterol Hepatol. 2013; 11:1636-45.LoombaRLiuJYangHILeeMHLuSNWangLYet alSynergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma20131116364510.1016/j.cgh.2013.04.043410077723669307Search in Google Scholar
El-Serag HB. Hepatocellular carcinoma. N Engl J Med. 2011; 365:1118-27.El-SeragHBHepatocellular carcinoma201136511182710.1056/NEJMra100168321992124Search in Google Scholar
Yuen MF, Yuan HJ, Wong DK, Yuen JC, Wong WM, Chan AO, et al. Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications. Gut. 2005; 54:1610-4.YuenMFYuanHJWongDKYuenJCWongWMChanAOet alPrognostic determinants for chronic hepatitis B in Asians: therapeutic implications2005541610410.1136/gut.2005.065136177476815871997Search in Google Scholar
Yang HI, Lu SN, Liaw YF, You SL, Sun CA, Wang LY, et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med. 2002; 347:168-74.YangHILuSNLiawYFYouSLSunCAWangLYet alHepatitis B e antigen and the risk of hepatocellular carcinoma20023471687410.1056/NEJMoa01321512124405Search in Google Scholar
Chen CJ, Yang HI, Su J, Jen CL, You SL, Lu SN, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA. 2006; 295:65-73.ChenCJYangHISuJJenCLYouSLLuSNet alRisk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level2006295657310.1001/jama.295.1.6516391218Search in Google Scholar
Tseng TC, Liu CJ, Yang HC, Su TH, Wang CC, Chen CL, et al. High levels of hepatitis B surface antigen increase risk of hepatocellular carcinoma in patients with low HBV load. Gastroenterology. 2012; 142: 1140-9.TsengTCLiuCJYangHCSuTHWangCCChenCLet alHigh levels of hepatitis B surface antigen increase risk of hepatocellular carcinoma in patients with low HBV load20121421140910.1053/j.gastro.2012.02.00722333950Search in Google Scholar
Yang HI, Yeh SH, Chen PJ, Iloeje UH, Jen CL, Su J, et al. Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. J Natl Cancer Inst. 2008; 100:1134-43.YangHIYehSHChenPJ Iloeje UHJenCLSuJet alAssociations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma200810011344310.1093/jnci/djn243251816618695135Search in Google Scholar
Papatheodoridis GV, Lampertico P, Manolakopoulos S, Lok A. Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: a systematic review. J Hepatol. 2010; 53: 348-56.PapatheodoridisGVLamperticoPManolakopoulosSLokAIncidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: a systematic review2010533485610.1016/j.jhep.2010.02.03520483498Search in Google Scholar
Wong GL, Chan HL, Chan HY, Tse PC, Tse YK, Mak CW, et al. Accuracy of risk scores for patients with chronic hepatitis B receiving entecavir treatment. Gastroenterology. 2013; 144:933-44.WongGLChanHLChanHYTsePCTseYKMakCWet alAccuracy of risk scores for patients with chronic hepatitis B receiving entecavir treatment20131449334410.1053/j.gastro.2013.02.00223415803Search in Google Scholar
Papatheodoridis G, Dalekos G, Sypsa V, Yurdaydin C, Buti M, Goulis J, et al. PAGE-B: A risk score for hepatocellular carcinoma in Caucasians with chronic hepatitis B under a 5-year entecavir or tenofovir therapy. J Hepatol. 2016; 64:800-6.PapatheodoridisGDalekosGSypsaVYurdaydinCButiMGoulisJet alPAGE-B: A risk score for hepatocellular carcinoma in Caucasians with chronic hepatitis B under a 5-year entecavir or tenofovir therapy201664800610.1016/j.jhep.2015.11.03526678008Search in Google Scholar
Jung KS, Kim SU, Song K, Park JY, Kim do Y, Ahn SH, et al. Validation of hepatitis B virus-related hepatocellular carcinoma prediction models in the era of antiviral therapy. Hepatology. 2015; 62:1757-66.JungKSKimSUSongKParkJYKimdo YAhnSHet alValidation of hepatitis B virus-related hepatocellular carcinoma prediction models in the era of antiviral therapy20156217576610.1002/hep.2811526249025Search in Google Scholar
Lee HW, Yoo EJ, Kim BK, Kim SU, Park JY, Kim do Y, et al. Prediction of development of liver-related events by transient elastography in hepatitis B patients with complete virological response on antiviral therapy. Am J Gastroenterol. 2014; 109:1241-9.LeeHWYooEJKimBKKimSUParkJYKimdo Yet alPrediction of development of liver-related events by transient elastography in hepatitis B patients with complete virological response on antiviral therapy20141091241910.1038/ajg.2014.15724957159Search in Google Scholar
McMahon BJ, Bulkow L, Harpster A, Snowball M, Lanier A, Sacco F, et al. Screening for hepatocellular carcinoma in Alaska natives infected with chronic hepatitis B: a 16-year population-based study. Hepatology. 2000; 32:842-6.McMahonBJBulkowLHarpsterASnowballMLanierASaccoFet alScreening for hepatocellular carcinoma in Alaska natives infected with chronic hepatitis B: a 16-year population-based study200032842610.1053/jhep.2000.1791411003632Search in Google Scholar
Wong LL, Limm WM, Severino R, Wong LM. Improved survival with screening for hepatocellular carcinoma. Liver Transpl. 2000; 6:320-5.WongLLLimmWMSeverinoRWongLMImproved survival with screening for hepatocellular carcinoma20006320510.1053/lv.2000.487510827233Search in Google Scholar
Welch HG, Schwartz LM, Woloshin S. Are increasing 5-year survival rates evidence of success against cancer? JAMA. 2000; 283:2975-8.WelchHGSchwartzLMWoloshinSAre increasing 5-year survival rates evidence of success against cancer?20002832975810.1001/jama.283.22.297510865276Search in Google Scholar
Zhang BH, Yang BH, Tang ZY. Randomized controlled trial of screening for hepatocellular carcinoma. J Cancer Res Clinical Oncol. 2004; 130:417-22.ZhangBHYangBHTangZYRandomized controlled trial of screening for hepatocellular carcinoma20041304172210.1007/s00432-004-0552-015042359Search in Google Scholar
Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology. 2011; 53:1020-2.BruixJShermanMManagement of hepatocellular carcinoma: an update2011531020210.1002/hep.24199308499121374666Search in Google Scholar
Omata M, Lesmana LA, Tateishi R, Chen PJ, Lin SM, Yoshida H, et al. Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma. Hepatol Int. 2010; 4: 439-74.OmataMLesmanaLATateishiRChenPJLinSMYoshidaHet alAsian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma201044397410.1007/s12072-010-9165-7290056120827404Search in Google Scholar
EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2012; 56: 908-43.EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma2012569084310.1016/j.jhep.2011.12.00122424438Search in Google Scholar
Omata M, Lesmana LA, Tateishi R, Chen PJ, Lin SM, Yoshida H, et al. Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma. Hepatol Int. 2010; 4: 439-74.OmataMLesmanaLATateishiRChenPJLinSMYoshidaHet alAsian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma201044397410.1007/s12072-010-9165-7Search in Google Scholar
Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology. 2011; 53:1020-2.BruixJShermanMManagement of hepatocellular carcinoma: an update2011531020210.1002/hep.24199Search in Google Scholar
EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2012; 56: 908-43.EASL-EORTC clinical practice guidelinesJ Hepatol20125610.1016/j.jhep.2011.12.001Search in Google Scholar
Eltabbakh M, Zaghla H, Abdel-Razek W, Elshinnawy H, Ezzat S, Gomaa A, et al. Utility and cost-effectiveness of screening for hepatocellular carcinoma in a resource-limited setting. Med Oncol. 2015; 32:432. doi: 10.1007/s12032-014-0432-7.EltabbakhMZaghlaHAbdel-RazekWElshinnawyHEzzatSGomaaAet alUtility and cost-effectiveness of screening for hepatocellular carcinoma in a resource-limited setting20153243210.1007/s12032-014-0432-725502085Open DOISearch in Google Scholar
Paul SB, Sreenivas V, Gulati MS, Madan K, Gupta AK, Mukhopadhyay S, et al. Economic evaluation of a surveillance program of hepatocellular carcinoma (HCC) in India. Hepatol Int. 2008; 2:231-6.PaulSB eenivas VSrGulatiMSMadanKGuptaAKMukhopadhyaySet alEconomic evaluation of a surveillance program of hepatocellular carcinoma (HCC) in India20082231610.1007/s12072-008-9054-5271684319669309Search in Google Scholar
Yuen MF, Lai CL. Screening for hepatocellular carcinoma: survival benefit and cost-effectiveness. Ann Oncol. 2003; 14:1463-7.YuenMFLaiCLScreening for hepatocellular carcinoma: survival benefit and cost-effectiveness2003141463710.1093/annonc/mdg40014504044Search in Google Scholar
World Health Organization. Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection. [online] 2013. [cited on 2016 Jan 15]. Available from: http://apps.who.int/iris/bitstream/10665/154590/1/9789241549059_eng.pdf[online]2013cited on2016Jan15Available fromhttp://apps.who.int/iris/bitstream/10665/154590/1/9789241549059_eng.pdfSearch in Google Scholar
Zanetti AR, Van Damme P, Shouval D. The global impact of vaccination against hepatitis B: a historical overview. Vaccine. 2008; 26:6266-73.ZanettiARVanDamme PShouvalDThe global impact of vaccination against hepatitis B: a historical overview20082662667310.1016/j.vaccine.2008.09.05618848855Search in Google Scholar
Lemoine M, Nayagam S, Thursz M. Viral hepatitis in resource-limited countries and access to antiviral therapies: current and future challenges. Future Virol. 2013; 8:371-80.LemoineMNayagamSThurszMViral hepatitis in resource-limited countries and access to antiviral therapies: current and future challenges201383718010.2217/fvl.13.11364623923662157Search in Google Scholar
Yuen MF, Tanaka Y, Fong DY, Fung J, Wong DK, Yuen JC, et al. Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B. J Hepatol. 2009; 50:80-8.YuenMFTanakaYFongDYFungJWongDKYuenJCet alIndependent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B20095080810.1016/j.jhep.2008.07.02318977053Search in Google Scholar
Wong VW, Chan SL, Mo F, Chan TC, Loong HH, Wong GL, et al. Clinical scoring system to predict hepatocellular carcinoma in chronic hepatitis B carriers. J Clin Oncol. 2010; 28:1660-5.WongVWChanSLMoFChanTCLoongHHWongGLet alClinical scoring system to predict hepatocellular carcinoma in chronic hepatitis B carriers2010281660510.1200/JCO.2009.26.267520194845Search in Google Scholar
Papatheodoridis GV, Dalekos GN, Yurdaydin C, Buti M, Goulis J, Arends P, et al. Incidence and predictors of hepatocellular carcinoma in Caucasian chronic hepatitis B patients receiving entecavir or tenofovir. J Hepatol. 2015; 62:363-70.PapatheodoridisGVDalekosGNYurdaydinCButiMGoulisJArendsPet alIncidence and predictors of hepatocellular carcinoma in Caucasian chronic hepatitis B patients receiving entecavir or tenofovir2015623637010.1016/j.jhep.2014.08.04525195548Search in Google Scholar
Arends P, Sonneveld MJ, Zoutendijk R, Carey I, Brown A, Fasano M, et al. Entecavir treatment does not eliminate the risk of hepatocellular carcinoma in chronic hepatitis B: limited role for risk scores in Caucasians. Gut. 2015; 64:1289-95.ArendsPSonneveldMJZoutendijkRCareyIBrownAFasanoMet alEntecavir treatment does not eliminate the risk of hepatocellular carcinoma in chronic hepatitis B: limited role for risk scores in Caucasians20156412899510.1136/gutjnl-2014-30702325011935Search in Google Scholar
Abu-Amara M, Cerocchi O, Malhi G, Sharma S, Yim C, Shah H, et al. The applicability of hepatocellular carcinoma risk prediction scores in a North American patient population with chronic hepatitis B infection. Gut. 2015.Abu-AmaraMCerocchiOMalhiGSharmaSYimCShahHet alThe applicability of hepatocellular carcinoma risk prediction scores in a North American patient population with chronic hepatitis B infection201510.1136/gutjnl-2014-30909925934760Search in Google Scholar
Merican I, Guan R, Amarapuka D, Alexander MJ, Chutaputti A, Chien RN, et al. Chronic hepatitis B virus infection in Asian countries. J Gastroenterol Hepatol. 2000; 15:1356-61.MericanIGuanRAmarapukaDAlexanderMJChutaputtiAChienRNet alChronic hepatitis B virus infection in Asian countries20001513566110.1046/j.1440-1746.2000.0150121356.x11197043Search in Google Scholar
Alter MJ, Hadler SC, Margolis HS, Alexander WJ, Hu PY, Judson FN, et al. The changing epidemiology of hepatitis B in the United States. Need for alternative vaccination strategies. JAMA. 1990; 263:1218-22.AlterMJHadlerSCMargolisHSAlexanderWJHuPYJudsonFNet alThe changing epidemiology of hepatitis B in the United States. Need for alternative vaccination strategies199026312182210.1001/jama.263.9.1218Search in Google Scholar
Lindh M, Andersson AS, Gusdal A. Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus—large-scale analysis using a new genotyping method. J Infect Dis. 1997; 175:1285-93.LindhMAnderssonASGusdalAGenotypes, nt 1858 variants, and geographic origin of hepatitis B virus—large-scale analysis using a new genotyping method199717512859310.1086/5164589180165Search in Google Scholar
Zhang H, Zhai Y, Hu Z, Wu C, Qian J, Jia W, et al. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet. 2010; 42:755-8.ZhangHZhaiYHuZWuCQianJJiaWet alGenome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers201042755810.1038/ng.63820676096Search in Google Scholar
Colli A, Fraquelli M, Andreoletti M, Marino B, Zuccoli E, Conte D. Severe liver fibrosis or cirrhosis: accuracy of US for detection—analysis of 300 cases. Radiology. 2003; 227:89-94.ColliAFraquelliMAndreolettiMMarinoBZuccoliEConteDSevere liver fibrosis or cirrhosis: accuracy of US for detection—analysis of 300 cases2003227899410.1148/radiol.227202019312601199Search in Google Scholar
Xiao G, Yang J, Yan L. Comparison of diagnostic accuracy of aspartate aminotransferase to platelet ratio index and fibrosis-4 index for detecting liver fibrosis in adult patients with chronic hepatitis B virus infection: a systemic review and meta-analysis. Hepatology. 2015; 61:292-302.XiaoGYangJYanLComparison of diagnostic accuracy of aspartate aminotransferase to platelet ratio index and fibrosis-4 index for detecting liver fibrosis in adult patients with chronic hepatitis B virus infection: a systemic review and meta-analysis20156129230210.1002/hep.2738225132233Search in Google Scholar
Friedrich-Rust M, Ong MF, Martens S, Sarrazin C, Bojunga J, Zeuzem S, et al. Performance of transient elastography for the staging of liver fibrosis: a meta-analysis. Gastroenterology. 2008; 134:960-74.Friedrich-RustMOngMFMartensSSarrazinCBojungaJZeuzemSet alPerformance of transient elastography for the staging of liver fibrosis: a meta-analysis20081349607410.1053/j.gastro.2008.01.03418395077Search in Google Scholar
Jung KS, Kim SU, Ahn SH, Park YN, Kim do Y, Park J Y, et al. Risk assessment of hepatitis B virus-related hepatocellular carcinoma development using liver stiffness measurement (FibroScan). Hepatology. 2011; 53:885-94.JungKSKimSUAhnSHParkYNKimdo YParkJ Yet alRisk assessment of hepatitis B virus-related hepatocellular carcinoma development using liver stiffness measurement (FibroScan)2011538859410.1002/hep.2412121319193Search in Google Scholar
Wong GL, Chan HL, Wong CK, Leung C, Chan CY, Ho PP, et al. Liver stiffness-based optimization of hepatocellular carcinoma risk score in patients with chronic hepatitis B. J Hepatol. 2014; 60:339-45.WongGLChanHLWongCKLeungCChanCYHoPPet alLiver stiffness-based optimization of hepatocellular carcinoma risk score in patients with chronic hepatitis B2014603394510.1016/j.jhep.2013.09.02924128413Search in Google Scholar
Branchi F, Conti CB, Baccarin A, Lampertico P, Conte D, Fraquelli M. Non-invasive assessment of liver fibrosis in chronic hepatitis B. World J Gastroenterol. 2014; 20:14568-80.BranchiFContiCBBaccarinALamperticoPConteDFraquelliMNon-invasive assessment of liver fibrosis in chronic hepatitis B201420145688010.3748/wjg.v20.i40.14568420952425356021Search in Google Scholar
Kim BK, Kim HS, Park JY, Kim do Y, Ahn SH, Chon CY, et al. Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B. PLoS One. 2012; 7:e41964.KimBKKimHSParkJYKimdo YAhnSHChonCYet alProspective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B20127e4196410.1371/journal.pone.0041964340705022848675Search in Google Scholar
Kim BK, Kim HS, Yoo EJ, Oh EJ, Park JY, Kim do Y, et al. Risk assessment of clinical outcomes in Asian patients with chronic hepatitis B using enhanced liver fibrosis test. Hepatology. 2014; 60:1911-9.KimBKKimHSYooEJOhEJParkJYKimdo Yet alRisk assessment of clinical outcomes in Asian patients with chronic hepatitis B using enhanced liver fibrosis test2014601911910.1002/hep.2738925142433Search in Google Scholar
Yuen MF, Tanaka Y, Fong DY, Fung J, Wong DK, Yuen JC, et al. Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B. J Hepatol. 2009; 50:80-8.YuenMFTanakaYFongDYFungJWongDKYuenJCet alIndependent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B20095080810.1016/j.jhep.2008.07.02318977053Search in Google Scholar
Wong VW, Chan SL, Mo F, Chan TC, Loong HH, Wong GL, et al. Clinical scoring system to predict hepatocellular carcinoma in chronic hepatitis B carriers. J Clinical Oncol. 2010; 28:1660-5.WongVWChanSLMoFChanTCLoongHHWongGLet alClinical scoring system to predict hepatocellular carcinoma in chronic hepatitis B carriers2010281660510.1200/JCO.2009.26.267520194845Search in Google Scholar
Yang HI, Yuen MF, Chan HL, Han KH, Chen PJ, Kim DY, et al. Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score. Lancet Oncol. 2011; 12:568-74.YangHIYuenMFChanHLHanKHChenPJKimDYet alRisk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score2011125687410.1016/S1470-2045(11)70077-8Search in Google Scholar
Papatheodoridis G, Dalekos G, Sypsa V, Yurdaydin C, Buti M, Goulis J, et al. PAGE-B: a risk score for hepatocellular carcinoma in Caucasians with chronic hepatitis B under a 5-year entecavir or tenofovir therapy. J Hepatol. 2016: doi: 10.1016/j.jhep.2015.11.035.PapatheodoridisGDalekosGSypsaVYurdaydinCButiMGoulisJet alPAGE-B: a risk score for hepatocellular carcinoma in Caucasians with chronic hepatitis B under a 5-year entecavir or tenofovir therapy201610.1016/j.jhep.2015.11.03526678008Open DOISearch in Google Scholar