<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Interest in and thereby also development of ordered mesoporous silicates as drug delivery devices have grown immensely over the past few years. On hand selected cases from the literature, the power of such systems as delivery devices has been established. Specifically, it is shown how it is possible to enhance the release kinetics of poorly soluble drugs by embedding them in mesoporous silicates. Further critical factors governing the structure and release of the model drug itraconazole incorporated in an SBA-15 matrix are briefly reviewed. The possibility of functionalizing the surface of mesoporous matrices also under harsher conditions offers a broad platform for the design of stimuli-responsive drug release, including pH responsive systems and systems which respond to the presence of specific ions, reducing agents, magnetic field or UV light, whose efficiency and biocompatibility has been established <italic>in vitro.</italic></p></abstract>

Interest in and thereby also development of ordered mesoporous silicates as drug delivery devices have grown immensely over the past few years. On hand selected cases from the literature, the power of such systems as delivery devices has been established. Specifically, it is shown how it is possible to enhance the release kinetics of poorly soluble drugs by embedding them in mesoporous silicates. Further critical factors governing the structure and release of the model drug itraconazole incorporated in an SBA-15 matrix are briefly reviewed. The possibility of functionalizing the surface of mesoporous matrices also under harsher conditions offers a broad platform for the design of stimuli-responsive drug release, including pH responsive systems and systems which respond to the presence of specific ions, reducing agents, magnetic field or UV light, whose efficiency and biocompatibility has been established in vitro.

Ordered mesoporous silicates as matrices for controlled release of drugs

National Institute of Chemistry, 1001 Ljubljana, Slovenia

Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia

Acta Pharmaceutica

{"article-title":"Ordered mesoporous silicates as matrices for controlled release of drugs"}

Interest in and thereby also development of ordered mesoporous silicates as drug delivery devices have grown immensely over the past few years. On hand...

Ordered mesoporous silicates as matrices for controlled release of drugs

Pubblicato online: 17 dic 2010

Pagine: 373 - 385

DOI: https://doi.org/10.2478/v1007-010-0037-4

Parole chiave
mezoporozni silikati, dostavni sistemi učinkovin, prirejeno sproščanje

This content is open access.

Ordered mesoporous silicates as matrices for controlled release of drugs

Pubblicato online: 17 dic 2010

Pagine: 373 - 385

DOI: https://doi.org/10.2478/v1007-010-0037-4

Parole chiavemezoporozni silikati, dostavni sistemi učinkovin, prirejeno sproščanje

This content is open access.

Parole chiave
mezoporozni silikati, dostavni sistemi učinkovin, prirejeno sproščanje