<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Gallstone disease and Cholesterolosis may be independent diseases or forms of the same disease, caused by impairment of cholesterol metabolism. Gallstone disease is characterized by formation of cholesterol concrements in the gallbladder cavity. Cholesterolosis is a hyperplastic cholecistosis, caused by cholesterol accumulation in the gallbladder wall with subsequent proliferation of gallbladder normal tissue elements. We describe monozygotic twin sisters, one of whom developed gallstone disease and the other developed cholesterolosis. Monozygosity was verified by a DNA fingerprinting method. Both had identical heterogeneity of plasma low density lipoprotein (LDL) subfractions, but associated with different functional conditions within the gallbladder. The different manifestations may be due to epigenetic, metabolic or environmental factors, since both had a common genetic basis.</p></abstract>

Gallstone disease and Cholesterolosis may be independent diseases or forms of the same disease, caused by impairment of cholesterol metabolism. Gallstone disease is characterized by formation of cholesterol concrements in the gallbladder cavity. Cholesterolosis is a hyperplastic cholecistosis, caused by cholesterol accumulation in the gallbladder wall with subsequent proliferation of gallbladder normal tissue elements. We describe monozygotic twin sisters, one of whom developed gallstone disease and the other developed cholesterolosis. Monozygosity was verified by a DNA fingerprinting method. Both had identical heterogeneity of plasma low density lipoprotein (LDL) subfractions, but associated with different functional conditions within the gallbladder. The different manifestations may be due to epigenetic, metabolic or environmental factors, since both had a common genetic basis.

Gallstone Disease and Cholesterolosis in Monozygotic Twin Sisters

Moscow Sechenov Medical Academy, Moscow, Russia

Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia

Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

Balkan Journal of Medical Genetics

{"article-title":"Gallstone Disease and Cholesterolosis in Monozygotic Twin Sisters"}

Gallstone disease and Cholesterolosis may be independent diseases or forms of the same disease, caused by impairment of cholesterol metabolism. Gallstone...

Gallstone Disease and Cholesterolosis in Monozygotic Twin Sisters

Pubblicato online: 10 ott 2007

Pagine: 39 - 42

DOI: https://doi.org/10.2478/v10034-007-0007-4

Parole chiave
Cholesterolosis, DNA fingerprinting, Gallstone disease, Monozygotic twin sisters, Multifactorial disorders

This content is open access.

Gallstone Disease and Cholesterolosis in Monozygotic Twin Sisters

Pubblicato online: 10 ott 2007

Pagine: 39 - 42

DOI: https://doi.org/10.2478/v10034-007-0007-4

Parole chiaveCholesterolosis, DNA fingerprinting, Gallstone disease, Monozygotic twin sisters, Multifactorial disorders

This content is open access.

Parole chiave
Cholesterolosis, DNA fingerprinting, Gallstone disease, Monozygotic twin sisters, Multifactorial disorders