<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2019-0016_s_006_w2aab3b7b3b1b6b1aab1c18b1Aa"><h3>Background</h3><p>Malignant mesothelioma (MM) is a rare aggressive tumour of mesothelium caused by asbestos exposure. It has been suggested that the genetic variability of proteins involved in DNA repair mechanisms affects the risk of MM. This study investigated the influence of functional polymorphisms in <italic>ERCC1</italic> and <italic>XRCC1</italic> genes, the interactions between these polymorphisms as well as the interactions between these polymorphisms and asbestos exposure on MM risk.</p></sec><sec id="j_raon-2019-0016_s_007_w2aab3b7b3b1b6b1aab1c18b2Aa"><h3>Patients and methods</h3><p>In total, 237 cases with MM and 193 controls with no asbestos-related disease were genotyped for <italic>ERCC1</italic> and <italic>XRCC1</italic> polymorphisms.</p></sec><sec id="j_raon-2019-0016_s_008_w2aab3b7b3b1b6b1aab1c18b3Aa"><h3>Results</h3><p><italic>ERCC1</italic> rs3212986 polymorphism was significantly associated with a decreased risk of MM (odds ratio [OR] = 0.61; 95% confidence interval [CI] = 0.41–0.91; p = 0.014). No associations were observed between other genetic polymorphisms and MM risk. Interactions between polymorphisms did not significantly influence MM risk. Interaction between <italic>ERCC1</italic> rs11615 and asbestos exposure significantly influenced MM risk (OR = 3.61; 95% CI = 1.12–11.66; p = 0.032). Carriers of polymorphic <italic>ERCC1</italic> rs11615 allele who were exposed to low level of asbestos had a decreased risk of MM (OR = 0.40; 95% CI = 0.19–0.84; p = 0.016). Interactions between other polymorphisms and asbestos exposure did not significantly influence MM risk.</p></sec><sec id="j_raon-2019-0016_s_009_w2aab3b7b3b1b6b1aab1c18b4Aa"><h3>Conclusions</h3><p>Our findings suggest that the genetic variability of DNA repair mechanisms could contribute to the risk of developing MM.</p></sec></abstract>

BackgroundMalignant mesothelioma (MM) is a rare aggressive tumour of mesothelium caused by asbestos exposure. It has been suggested that the genetic variability of proteins involved in DNA repair mechanisms affects the risk of MM. This study investigated the influence of functional polymorphisms in ERCC1 and XRCC1 genes, the interactions between these polymorphisms as well as the interactions between these polymorphisms and asbestos exposure on MM risk.Patients and methodsIn total, 237 cases with MM and 193 controls with no asbestos-related disease were genotyped for ERCC1 and XRCC1 polymorphisms.ResultsERCC1 rs3212986 polymorphism was significantly associated with a decreased risk of MM (odds ratio [OR] = 0.61; 95% confidence interval [CI] = 0.41–0.91; p = 0.014). No associations were observed between other genetic polymorphisms and MM risk. Interactions between polymorphisms did not significantly influence MM risk. Interaction between ERCC1 rs11615 and asbestos exposure significantly influenced MM risk (OR = 3.61; 95% CI = 1.12–11.66; p = 0.032). Carriers of polymorphic ERCC1 rs11615 allele who were exposed to low level of asbestos had a decreased risk of MM (OR = 0.40; 95% CI = 0.19–0.84; p = 0.016). Interactions between other polymorphisms and asbestos exposure did not significantly influence MM risk.ConclusionsOur findings suggest that the genetic variability of DNA repair mechanisms could contribute to the risk of developing MM.

The influence of genetic variability of DNA repair mechanisms on the risk of malignant mesothelioma

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundMalignant mesothelioma (MM) is a rare aggressive tumour of mesothelium caused by asbestos exposure. It has been suggested that the genetic...

The influence of genetic variability of DNA repair mechanisms on the risk of malignant mesothelioma

Article Category: Research Article

Pubblicato online: 14 mar 2019

Pagine: 206 - 212

Ricevuto: 06 feb 2019

Accettato: 25 feb 2019

DOI: https://doi.org/10.2478/raon-2019-0016

© 2019 Kristina Levpuscek, Katja Goricar, Viljem Kovac, Vita Dolzan, Alenka Franko, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.