<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Aim</bold>. Rheumatoid arthritis (RA) may influence not only abdominal fat, but also whole body adiposity, since it is associated with chronic inflammation and disability. The study aims to evaluate the whole body adiposity of RA patients and to assess potential influences of disease specific measures.<bold>Methods</bold>. The study was designed to include Caucasian postmenopausal female RA patients and age-matched postmenopausal female controls. Each subject underwent on the same day clinical examination, laboratory tests, whole body dual X-ray absorptiometry (DXA) composition and physical activity estimation using a self-administered questionnaire.<bold>Results</bold>. A total of 107 RA women and 104 matched controls were included. Compared to controls, the RA group had less physical activity and a higher prevalence of normal weight obesity. Overfat RA women had a significantly higher toll of inflammation, disease activity, glucocorticoid treatment and sedentary behavior. RA women with inflammation, glucocorticoid treatment and higher disease activity class had higher whole body and trunk adipose tissue indices and higher prevalence of overfat status. Glucocorticoid treatment, inflammation, disease duration and severity correlated with whole body adipose tissue and significantly predicted high adiposity content and overfat phenotypes.<bold>Conclusions</bold>. RA disease duration and severity are associated with higher whole body and regional adiposity. Low-dose glucocorticoid treatment seems to contribute to adiposity gain and redistribution. Clinicians may need to assess body composition and physical activity in RA patients in order to fully manage cardiovascular outcomes and quality of life.</abstract>

Aim. Rheumatoid arthritis (RA) may influence not only abdominal fat, but also whole body adiposity, since it is associated with chronic inflammation and disability. The study aims to evaluate the whole body adiposity of RA patients and to assess potential influences of disease specific measures.Methods. The study was designed to include Caucasian postmenopausal female RA patients and age-matched postmenopausal female controls. Each subject underwent on the same day clinical examination, laboratory tests, whole body dual X-ray absorptiometry (DXA) composition and physical activity estimation using a self-administered questionnaire.Results. A total of 107 RA women and 104 matched controls were included. Compared to controls, the RA group had less physical activity and a higher prevalence of normal weight obesity. Overfat RA women had a significantly higher toll of inflammation, disease activity, glucocorticoid treatment and sedentary behavior. RA women with inflammation, glucocorticoid treatment and higher disease activity class had higher whole body and trunk adipose tissue indices and higher prevalence of overfat status. Glucocorticoid treatment, inflammation, disease duration and severity correlated with whole body adipose tissue and significantly predicted high adiposity content and overfat phenotypes.Conclusions. RA disease duration and severity are associated with higher whole body and regional adiposity. Low-dose glucocorticoid treatment seems to contribute to adiposity gain and redistribution. Clinicians may need to assess body composition and physical activity in RA patients in order to fully manage cardiovascular outcomes and quality of life.

Dual X-ray absorptiometry whole body composition of adipose tissue in rheumatoid arthritis

“Sfânta Maria” Clinical Hospital, Bucharest

“Carol Davila” University of Medicine and Pharmacy, Department of Internal Medicine and Rheumatology, Bucharest

Research Centre of the Pathology and Treatment of Systemic Rheumatic Diseases, Bucharest

Romanian Journal of Internal Medicine

This chapter is distributed under the terms of the Creative Commons Attribution 4.0 Public License.

Aim. Rheumatoid arthritis (RA) may influence not only abdominal fat, but also whole body adiposity, since it is associated with chronic inflammation and...

Dual X-ray absorptiometry whole body composition of adipose tissue in rheumatoid arthritis

Pubblicato online: 14 ott 2015

Pagine: 237 - 247

Ricevuto: 09 mag 2015

DOI: https://doi.org/10.1515/rjim-2015-0031

Parole chiave
rheumatoid arthritis, DXA body composition, adipose tissue, obesity

© 2015 C. Popescu et al., published by De Gruyter Open

This chapter is distributed under the terms of the Creative Commons Attribution 4.0 Public License.

Dual X-ray absorptiometry whole body composition of adipose tissue in rheumatoid arthritis

Pubblicato online: 14 ott 2015

Pagine: 237 - 247

Ricevuto: 09 mag 2015

DOI: https://doi.org/10.1515/rjim-2015-0031

Parole chiaverheumatoid arthritis, DXA body composition, adipose tissue, obesity

© 2015 C. Popescu et al., published by De Gruyter Open

This chapter is distributed under the terms of the Creative Commons Attribution 4.0 Public License.

Parole chiave
rheumatoid arthritis, DXA body composition, adipose tissue, obesity