Spruce Needle Polyprenols Protect Against Atorvastatin-Induced Muscle Weakness and do not Influence Central Nervous System Functions in Rats

Abdelbaset, M., Safar, M. M., Mahmoud, S. S., Negm, S. A., Agha, A. M. (2014). Red yeast rice and coenzyme Q10 as safe alternatives to surmount atorvastatin-induced myopathy in hyperlipidemic rats. Can. J. Physiol. Pharmacol., 92 (6), 481–489.10.1139/cjpp-2013-0430Search in Google Scholar

Abourjaily, H. M., Alsheikh-Ali, A. A., Karas, R. H. (2003). Comparison of the frequency of adverse events in patients treated with atorvastatin or simvastatin. Amer. J. Cardiol., 91 (8), 999–1002.10.1016/S0002-9149(03)00124-3Search in Google Scholar

Baker, S. K. (2005). Molecular clues into the pathogenesis of statin-mediated muscle toxicity. Muscle Nerve, 31 (5), 572–580.10.1002/mus.2029115712281Search in Google Scholar

Ballard, K. D., Parker, B. A., Capizzi, J. A., Grimaldi, A. S., Clarkson, P. M., Cole, S. M., Keadle, J., Chipkin, S., Pescatello, L. S., Simpson, K., White, C. M., Thompson, P. D. (2013). Increases in creatine kinase with atorvastatin treatment are not associated with decreases in muscular performance. Atherosclerosis, 230 (1), 121–124.10.1016/j.atherosclerosis.2013.07.001377987423958263Search in Google Scholar

Bays, H. (2006). Statin safety: An overview and assessment of the data-2005. Amer. J. Cardiol., 97 (8A), 6C–26C.10.1016/j.amjcard.2005.12.00616581330Search in Google Scholar

Bitzur, R., Cohen, H., Kamari, Y., Harats, D. (2013). Intolerance to statins: Mechanisms and management. Diabetes Care, 36 (2), S325–S330.10.2337/dcS13-2038392079623882066Search in Google Scholar

Bizzarri, R., Cerbai, B., Signori, F. (2003). New perspectives for (S)-dolichol and (S)-nor dolichol synthesis and biological functions. Biogerontology, 4 (6), 353–363.10.1023/B:BGEN.0000006555.87407.04Search in Google Scholar

Buhaescu, I., Izzedine, H. (2007). Mevalonate pathway: a review of clinical and therapeutical implications. Clin. Biochem., 40 (9–10), 575–584.10.1016/j.clinbiochem.2007.03.01617467679Search in Google Scholar

Camerino, G. M., Pellegrino, M. A., Brocca, L. (2011). Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle. Biochem. Pharm., 81 (8), 1054–1064.10.1016/j.bcp.2011.01.02221300028Search in Google Scholar

Cantagrel, V., Lefeber, D. J. (2011). From glycosylation disorders to dolichol biosynthesis defects: A new class of metabolic diseases. J. Inherit. Metab. Dis., 34 (4), 859–867.10.1007/s10545-011-9301-0313777221384228Search in Google Scholar

Chojnacki, T., Dallner, G. (1983). The uptake of dietary polyprenols and their modification to active dolichols by the rat liver. J. Biol. Chem.,258 (2), 916–922.10.1016/S0021-9258(18)33138-7Search in Google Scholar

Chojnacki, T., Dallner, G. (1988). The biological role of dolichol. Biochem. J.,251 (1), 1–9.10.1042/bj2510001Search in Google Scholar

Dwajani, S., Kumar, V. S., Keerthi, D. (2012). Atorvastatin and simvastatin as analgesic agents in experimental models. J. Basic Clin. Pharm., 3 (4), 332–335.10.4103/0976-0105.105334Search in Google Scholar

Fedotova, J. O., Sultanov, V. S., Kuznetsova, N. N. (2010). Effect of new polyprenol drug ropren on anxiety-depressive-like behavior in rats with experimental Alzheimer disease. Eksp. Klin. Farmakol.,73 (9), 2–5.Search in Google Scholar

Fedotova, J., Soultanov, V., Nikitina, T. (2012). Ropren^® is a polyprenol preparation from coniferous plants that ameliorates cognitive deficiency in a rat model of beta-amyloid peptide-(25-35)-induced amnesia. Phytomedicine, 19 (5), 451–456.10.1016/j.phymed.2011.09.073Search in Google Scholar

Garcia, G. G., Miranda, H. F., Noriega, V. (2011). Antinociception induced by atorvastatin in different pain models. Pharmacol. Biochem. Behav., 100 (1), 125–129.10.1016/j.pbb.2011.08.007Search in Google Scholar

Hartley, M. D., Imperiali, B. (2012). At the membrane frontier: a prospectus on the remarkable evolutionary conservation of polyprenols and polyprenyl-phosphates. Arch. Biochem. Biophys., 517 (2), 83–97.10.1016/j.abb.2011.10.018Search in Google Scholar

Jaiswal, S. R., Sontakke, S. D. (2012). Experimental evaluation of analgesic and anti-inflammatory activity of simvastatin and atorvastatin. Indian J. Pharmacol., 44 (4), 475–479.Search in Google Scholar

Jakobsson, A., Swiezewska, E., Chojnacki, T. (1989). Uptake and modification of dietary polyprenols and dolichols in rat liver. FEBS Lett, 255 (1), 32–36.10.1016/0014-5793(89)81055-5Search in Google Scholar

Laaksonen, R. (2013). STOMPing forward: Statins, muscle complaints and CK. Atherosclerosis, 230 (2), 256–257.10.1016/j.atherosclerosis.2013.07.04424075753Search in Google Scholar

Madsen, C. S., Janovitz, E., Zhang, R. (2008). The Guinea pig as a preclinical model for demonstrating the efficacy and safety of statins. J. Pharmacol. Exp. Ther., 324 (2), 576–586.10.1124/jpet.107.13161517986646Search in Google Scholar

Mazroa, S. A., Asker, S. A. (2010). Myotoxic effects of atorvastatin drug (Lipitor) on the skeletal muscles of adult Mmale albino rats and the effect of L-carnitine co-administration light microscopical, immunohistochemical and biochemical Study. Egypt. J. Histol.,33 (3), 520–531.Search in Google Scholar

Manoukian, A. A., Bhagavan, N. V., Hayashi, T. (1990). Rhabdomyolysis secondary to lovastatin therapy. Clin. Chem., 36 (12), 2145–2147.10.1093/clinchem/36.12.2145Search in Google Scholar

Milenkovic, D., Jude, B., Morand, C. (2013). miRNA as molecular target of polyphenols underlying their biological effects. Free Radic. Biol. Med., 64, 40–51.10.1016/j.freeradbiomed.2013.05.04623751562Search in Google Scholar

Pronin, A. V., Danilov, L. L., Narovlyansky, A. N. (2014). Plant polyisoprenoids and control of cholesterol level. Arch. Immunol. Ther. Exp. (Warsz), 62 (1), 31–39.10.1007/s00005-013-0253-y389836023995915Search in Google Scholar

Rosenson, R. S., Baker, S. K., Jacobson, T. A. (2014). An assessment by the Statin Muscle Safety Task Force: 2014 update. J. Clin. Lipidol.,8 (3), S58–S71.10.1016/j.jacl.2014.03.00424793443Search in Google Scholar

Sathasivam, S., Lecky, B. (2008). Statin induced myopathy. British Medical Journal (BMJ),337, a2286.10.1136/bmj.a228618988647Search in Google Scholar

Sierra, S., Ramos, M. C., Molina, P. (2011). Statins as neuroprotectants:A comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death. J. Alzheimers Dis., 23 (2), 307–318.10.3233/JAD-2010-10117921098985Search in Google Scholar

Soner, B. C., Inan, S. Y., Güven, U. (2013). Combined treatment with resveratrol prevents the atorvastatin-induced myopathy in rat skeletal muscle. Afr. J. Pharm. Pharmacol.,7 (18), 1114–1118.10.5897/AJPP12.983Search in Google Scholar

Surmacz, L., Swiezewska, E. (2011). Polyisoprenoids — secondary metabolites or physiologically important superlipids? Biochem. Biophys. Res. Commun., 407 (4), 627–632.10.1016/j.bbrc.2011.03.05921419101Search in Google Scholar

Tuccori, M., Montagnani, S., Mantarro, S. (2014). Neuropsychiatric adverse events associated with statins: Epidemiology, pathophysiology, prevention and management. Central Nervous System Drugs, 28 (3), 249–272.10.1007/s40263-013-0135-124435290Search in Google Scholar

van der Most, P. J., Dolga, A. M., Nijholt, I. M. (2009). Statins: Mechanisms of neuroprotection. Prog. Neurobiol., 88 (1), 64–75.10.1016/j.pneurobio.2009.02.00219428962Search in Google Scholar

Wagstaff, L. R, Mitton, M. W., Arvik, B. M. (2003). Statin-associated memory loss: Analysis of 60 case reports and review of the literature. Pharmacother, 23 (7), 871–880.10.1592/phco.23.7.871.3272012885101Search in Google Scholar

Wang, C. Z., Wang, W. L., Ye, J. Z. (2008). Studies on separation of polyprenols from leaves of Ginkgo biloba L. by molecular short distillation. Chemistry and Industry of Forest Products, 28 (3), 23–27.Search in Google Scholar

Wang, C., He, L., Yan, M. (2014). Effects of polyprenols from needles of Pinus massoniana on ameliorating cognitive impairment in a d-galactose-induced mouse model. Age (Dordr), 36 (4), 9676.10.1007/s11357-014-9676-6415089924981114Search in Google Scholar

Werner, M., Sacher, J., Hohenegger, M. (2004). Mutual amplification of apoptosis by statin-induced mitochondrial stress and doxorubicin toxicity in human rhabdomyosarcoma cells. Brit. J. Pharmacol.,143 (6), 715–724.10.1038/sj.bjp.0705928157592315289292Search in Google Scholar

Wilkinson, M. J., Laffin, L. J., Davidson, M. H. (2014). Overcoming toxicity and side-effects of lipid-lowering therapies. Best Pract. Res. Clin. Endocrinol. Metab.,28 (3), 439–452.10.1016/j.beem.2014.01.00624840269Search in Google Scholar