<abstract xmlns="http://www.w3.org/1999/xhtml">Diabetes mellitus is one of the most common endocrine disorders and its continuous global increase is due to factors as population growth, urbanization, aging, and increasing prevalence of obesity and physical inactivity. The effect of pinworm infection on the development of hyperglycemia was examined in WBN/K-Lepf (fa/fa) rats, a new model of the obese type 2 diabetes mellitus (T2DM) with pancreatitis. The rats were orally administered <italic>Syphacia muris</italic> eggs (infected group) and distilled water (control group). Hyperglycemia onset in the infected group was significantly delayed compared to the control group. Neither body weight nor intake of food and water were affected by S. <italic>muris</italic> infection. This study demonstrated that S. <italic>muris</italic> infection delayed the onset of T2DM in <italic>fa/fa</italic> rats and suggested that elucidation of the underlying mechanism and relevant pathways in the helminth-mediated protection may lead to the development of a new strategy to prevent diabetes mellitus.</abstract>

Diabetes mellitus is one of the most common endocrine disorders and its continuous global increase is due to factors as population growth, urbanization, aging, and increasing prevalence of obesity and physical inactivity. The effect of pinworm infection on the development of hyperglycemia was examined in WBN/K-Lepf (fa/fa) rats, a new model of the obese type 2 diabetes mellitus (T2DM) with pancreatitis. The rats were orally administered Syphacia muris eggs (infected group) and distilled water (control group). Hyperglycemia onset in the infected group was significantly delayed compared to the control group. Neither body weight nor intake of food and water were affected by S. muris infection. This study demonstrated that S. muris infection delayed the onset of T2DM in fa/fa rats and suggested that elucidation of the underlying mechanism and relevant pathways in the helminth-mediated protection may lead to the development of a new strategy to prevent diabetes mellitus.

<italic>Syphacia muris</italic> infection delays the onset of hyperglycemia in <italic>WBN/Kob-Lepr</italic>fa rats, a new type 2 diabetes mellitus model

Laboratory of Parasitology, School of Veterinary Medicine, Azabu University. 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan

Laboratory of Pharmacology, School of Veterinary Medicine, Azabu University

Laboratory of Veterinary Immunology, School of Veterinary Medicine, Azabu University

Helminthologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

 infection delays the onset of hyperglycemia in  rats, a new type 2 diabetes mellitus model

Diabetes mellitus is one of the most common endocrine disorders and its continuous global increase is due to factors as population growth, urbanization, aging,...

Syphacia muris infection delays the onset of hyperglycemia in WBN/Kob-Lepr^fa rats, a new type 2 diabetes mellitus model

Pubblicato online: 02 feb 2015

Pagine: 58 - 62

Ricevuto: 10 lug 2014

Accettato: 13 ott 2014

DOI: https://doi.org/10.1515/helmin-2015-0010

Parole chiave
WBN/Kob-Lepr rats, type 2 diabetes mellitus,

© 2015 Institute of Parasitology, SAS, Košice

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Syphacia muris infection delays the onset of hyperglycemia in WBN/Kob-Leprfa rats, a new type 2 diabetes mellitus model

Pubblicato online: 02 feb 2015

Pagine: 58 - 62

Ricevuto: 10 lug 2014

Accettato: 13 ott 2014

DOI: https://doi.org/10.1515/helmin-2015-0010

Parole chiaveWBN/Kob-Lepr rats, type 2 diabetes mellitus,

© 2015 Institute of Parasitology, SAS, Košice

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Syphacia muris infection delays the onset of hyperglycemia in WBN/Kob-Lepr^fa rats, a new type 2 diabetes mellitus model

Parole chiave
WBN/Kob-Lepr rats, type 2 diabetes mellitus,