<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The paper deals with the results of an investigation of the release of selected amino acids (histidine, tryptophan, tyrosine) from model suspensions prepared by co-precipitation with zinc chloride. It has been proven that the influence of the Zn(II)/amino acid molar ratio on dissolution profiles of the tested amino acids and dissolution half-life (<italic>t</italic><sub>1/2</sub>) of histidine or tryptophan is significant. The amount of amino acid in the dispersed phase (supporting dose) is a determinant of the amino acid release profile. There is a minimal supporting dose (30.0 μmol of histidine or 17.4 μmol of tryptophan) that provides release of similar amounts of amino acid (4.1–4.6 μmol of histidine or 8.7–9.9 μmol of tryptophan) after the same time intervals. The tyrosine release profiles follow first order kinetics since the supporting dose (0.9–11.2 μmol) is limited by the tyrosine low solubility in water.</p></abstract>

The paper deals with the results of an investigation of the release of selected amino acids (histidine, tryptophan, tyrosine) from model suspensions prepared by co-precipitation with zinc chloride. It has been proven that the influence of the Zn(II)/amino acid molar ratio on dissolution profiles of the tested amino acids and dissolution half-life (t1/2) of histidine or tryptophan is significant. The amount of amino acid in the dispersed phase (supporting dose) is a determinant of the amino acid release profile. There is a minimal supporting dose (30.0 μmol of histidine or 17.4 μmol of tryptophan) that provides release of similar amounts of amino acid (4.1–4.6 μmol of histidine or 8.7–9.9 μmol of tryptophan) after the same time intervals. The tyrosine release profiles follow first order kinetics since the supporting dose (0.9–11.2 μmol) is limited by the tyrosine low solubility in water.

Release of selected amino acids from zinc carriers

Department of Applied, Pharmacy and Drug Technology, Medical University of Silesia, 41-200 Sosnowiec, Poland

Pharmaceutical Research and Product Plant »Biochefa«, 41-200 Sosnowiec, Poland

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Release of selected amino acids from zinc carriers"}

The paper deals with the results of an investigation of the release of selected amino acids (histidine, tryptophan, tyrosine) from model suspensions prepared...

Release of selected amino acids from zinc carriers

Pubblicato online: 28 mag 2016

Pagine: 269 - 277

Accettato: 16 feb 2016

DOI: https://doi.org/10.1515/acph-2016-0024

Parole chiave
amino acids, zinc, suspensions, dissolution, kinetics

© 2016 Renata Dyja et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Release of selected amino acids from zinc carriers

Pubblicato online: 28 mag 2016

Pagine: 269 - 277

Accettato: 16 feb 2016

DOI: https://doi.org/10.1515/acph-2016-0024

Parole chiaveamino acids, zinc, suspensions, dissolution, kinetics

© 2016 Renata Dyja et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
amino acids, zinc, suspensions, dissolution, kinetics