A meta-analysis of tumor necrosis factor-α-308 G>A polymorphism in gastric cancer
Article Category: Mini-review article
Pubblicato online: 10 set 2020
Pagine: 91 - 96
DOI: https://doi.org/10.1515/abm-2020-0014
Parole chiave
© 2020 Xin Jiang et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Background
Gastric cancer (GC) is the common cause of cancer-related deaths worldwide and inflammation represents the early phases in the GC.
Objective
To review the tumor necrosis factor (TNF)-α-308 G>A (GG, GA, and AA) in GC by meta-analysis studies for any differences in TNF-α-308 G>A gene polymorphisms.
Methods
Case–control studies published from 2003 to 2017 were identified by searching PubMed, EMASE, and the Internet with the English language. The analysis published on TNF-α-308 G>A polymorphism was analyzed and a limited number of articles were included in the present study. TNF-α-308 G>A from 4,157 patients and 5,185 healthy controls was evaluated. Studies were evaluated using Cochrane
Results
Overall, TNF-α-308 GA genotype showed significant association [
Conclusions
Results revealed nonsignificant association of TNF-α-308 genotypes (GG, GA, AA, and GA + AA) and GC. TNF-α-308GA genotype showed significant association whereas homozygous genotype AA did not show association with GC risk.