Potassium channel inhibitors induce oxidative stress in breast cancer cells

[1]Sosa V, Moline T, Somoza R, Paciucci R, Kondoh H, ME LL. Oxidative stress and cancer: an overview. Ageing Res Rev. 2013; 12:376–90.10.1016/j.arr.2012.10.00423123177SosaVMolineTSomozaRPaciucciRKondohHMeLL.Oxidative stress and cancer: an overviewAgeing Res Rev.2013123769023123177Open DOISearch in Google Scholar

[2]Gorrini C, Harris IS, Mak TW. Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 2013; 12:931–47.2428778110.1038/nrd4002GorriniCHarrisISMakTW.Modulation of oxidative stress as an anticancer strategyNat Rev Drug Discov.2013129314724287781Search in Google Scholar

[3]Gupta R, Sikka SC. Prostate cancer and oxidative stress. In: Laher I, editor. Systems biology of free radicals and antioxidants. Berlin: Springer-Verlag; 2014. p. 2835–50.GuptaRSikkaSC.Prostate cancer and oxidative stressLaherISystems biology of free radicals and antioxidantsBerlinSpringer-Verlag201428355010.1007/978-3-642-30018-9_116Search in Google Scholar

[4]Federico A, Morgillo F, Tuccillo C, Ciardiello F, Loguercio C. Chronic inflammation and oxidative stress in human carcinogenesis. Int J Cancer. 2007; 121:2381–6.1789386810.1002/ijc.23192FedericoAMorgilloFTuccilloCCiardielloFLoguercioC.Chronic inflammation and oxidative stress in human carcinogenesisInt J Cancer.20071212381617893868Search in Google Scholar

[5]Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer. 2011; 11:85–95.10.1038/nrc298121258394CairnsRAHarrisISMakTW.Regulation of cancer cell metabolismNat Rev Cancer.201111859521258394Open DOISearch in Google Scholar

[6]Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. 2009; 458:780–3.10.1038/nature0773319194462DiehnMChoRWLoboNAKaliskyTDorieMJKulpANAssociation of reactive oxygen species levels and radioresistance in cancer stem cellsNature.20094587803277861219194462Open DOISearch in Google Scholar

[7]Hecht F, Pessoa CF, Gentile LB, Rosenthal D, Carvalho DP, Fortunato RS. The role of oxidative stress on breast cancer development and therapy. Tumour Biol. 2016; 37:4281–91.10.1007/s13277-016-4873-9HechtFPessoaCFGentileLBRosenthalDCarvalhoDPFortunatoRS.The role of oxidative stress on breast cancer development and therapyTumour Biol.20163742819126815507Open DOISearch in Google Scholar

[8]Hernandes MS, Troncone LRP. Glycine as a neurotransmitter in the forebrain: a short review. J Neural Transm (Vienna). 2009; 116:1551–60.10.1007/s00702-009-0326-6HernandesMSTronconeLRP.Glycine as a neurotransmitter in the forebrain: a short reviewJ Neural Transm (Vienna).200911615516019826900Open DOISearch in Google Scholar

[9]Leanza L, Zoratti M, Gulbins E, Szabo I. Mitochondrial ion channels as oncological targets. Oncogene. 2014; 33:5569–81.10.1038/onc.2013.57824469031LeanzaLZorattiMGulbinsESzaboI.Mitochondrial ion channels as oncological targetsOncogene.20143355698124469031Open DOISearch in Google Scholar

[10]Villalonga N, Ferreres JC, Argilés JM, Condom E, Felipe A. Potassium channels are a new target field in anticancer drug design. Recent Pat Anticancer Drug Discov. 2007; 2:212–23.1822106410.2174/157489207782497181VillalongaNFerreresJCArgilésJMCondomEFelipeA.Potassium channels are a new target field in anticancer drug designRecent Pat Anticancer Drug Discov.200722122318221064Search in Google Scholar

[11]Leanza L, Managò A, Zoratti M, Gulbins E, Szabo I. Pharmacological targeting of ion channels for cancer therapy: In vivo evidences. Biochim Biophys Acta. 2016; 1863:1385–97.2665864210.1016/j.bbamcr.2015.11.032LeanzaLManagòAZorattiMGulbinsESzaboI.Pharmacological targeting of ion channels for cancer therapy: In vivo evidencesBiochim Biophys Acta.2016186313859726658642Search in Google Scholar

[12]Urrego D, Tomczak AP, Zahed F, Stühmer W, Pardo LA. Potassium channels in cell cycle and cell proliferation. Philos Trans R Soc Lond B Biol Sci. 2014; 369:20130094, 10.1098/rstb.2013.0094.24493742UrregoDTomczakAPZahedFStühmerWPardoLA.Potassium channels in cell cycle and cell proliferationPhilos Trans R Soc Lond B Biol Sci.20143692013009410.1098/rstb.2013.0094391734824493742Open DOISearch in Google Scholar

[13]Jang SH, Choi SY, Ryu PD, Lee SY. Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo. Eur J Pharmacol. 2011; 651:26–32.2108760210.1016/j.ejphar.2010.10.066JangSHChoiSYRyuPDLeeSY.Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivoEur J Pharmacol.2011651263221087602Search in Google Scholar

[14]Borowiec AS, Hague F, Harir N, Guénin S, Guerineau F, Gouilleux F, et al. IGF-1 activates hEAG K⁺ channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation. J Cell Physiol. 2007; 212:690–701.10.1002/jcp.2106517520698BorowiecASHagueFHarirNGuéninSGuerineauFGouilleuxFIGF-1 activates hEAG K⁺ channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferationJ Cell Physiol.200721269070117520698Open DOISearch in Google Scholar

[15]Brevet M, Ahidouch A, Sevestre H, Merviel P, El Hiani Y, Robbe M, et al. Expression of K⁺ channels in normal and cancerous human breast. Histol Histopathol. 2008; 23:965–72.18498071BrevetMAhidouchASevestreHMervielPEl HianiYRobbeMExpression of K⁺ channels in normal and cancerous human breastHistol Histopathol.20082396572Search in Google Scholar

[16]So EC, Huang Y-M, Hsing C-H, Liao Y-K, Wu S-N. Arecoline inhibits intermediate-conductance calcium-activated potassium channels in human glioblastoma cell lines. Eur J Pharmacol. 2015; 758:177–87.2584341410.1016/j.ejphar.2015.03.065SoECHuangY-MHsingC-HLiaoY-KWuS-N.Arecoline inhibits intermediate-conductance calcium-activated potassium channels in human glioblastoma cell linesEur J Pharmacol.20157581778725843414Search in Google Scholar

[17]Leanza L, Venturini E, Kadow S, Carpinteiro A, Gulbins E, Becker KA. Targeting a mitochondrial potassium channel to fight cancer. Cell Calcium. 2015; 58:131–8.10.1016/j.ceca.2014.09.00625443654LeanzaLVenturiniEKadowSCarpinteiroAGulbinsEBeckerKA.Targeting a mitochondrial potassium channel to fight cancerCell Calcium.201558131825443654Open DOISearch in Google Scholar

[18]Hu L, Pennington M, Jiang Q, Whartenby KA, Calabresi PA. Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4⁺ T lymphocytes. J Immunol. 2007; 179:4563–70.10.4049/jimmunol.179.7.456317878353HuLPenningtonMJiangQWhartenbyKACalabresiPA.Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4⁺ T lymphocytesJ Immunol.200717945637017878353Open DOISearch in Google Scholar

[19]García-Quiroz J, Camacho J. Astemizole: an old anti-histamine as a new promising anti-cancer drug. Anticancer Agents Med Chem. 2011; 11:307–14.2144350410.2174/187152011795347513García-QuirozJCamachoJ.Astemizole: an old anti-histamine as a new promising anti-cancer drugAnticancer Agents Med Chem.2011113071421443504Search in Google Scholar

[20]Kim Y, Kim WJ, Cha EJ. Quercetin-induced growth inhibition in human bladder cancer cells is associated with an increase in Ca²⁺-activated K⁺ channels. Korean J Physiol Pharmacol. 2011; 15:279–83.10.4196/kjpp.2011.15.5.279KimYKimWJChaEJ.Quercetin-induced growth inhibition in human bladder cancer cells is associated with an increase in Ca²⁺-activated K⁺ channelsKorean J Physiol Pharmacol.20111527983322279722128260Open DOISearch in Google Scholar

[21]Jang SH, Kang KS, Ryu PD, Lee SY. Kv1.3 voltage-gated K⁺ channel subunit as a potential diagnostic marker and therapeutic target for breast cancer. BMB Rep. 2009; 42:535–9.1971259210.5483/BMBRep.2009.42.8.535JangSHKangKSRyuPDLeeSY.Kv1.3 voltage-gated K⁺ channel subunit as a potential diagnostic marker and therapeutic target for breast cancerBMB Rep.2009425359Search in Google Scholar

[22]Chin LS, Park CC, Zitnay KM, Sinha M, DiPatri AJ Jr., Perillán P, et al. 4-Aminopyridine causes apoptosis and blocks an outward rectifier K⁺ channel in malignant astrocytoma cell lines. J Neurosci Res. 1997; 48:122–7.10.1002/(SICI)1097-4547(19970415)48:2<122::AID-JNR4>3.0.CO;2-E9130140ChinLSParkCCZitnayKMSinhaMDiPatriAJ Jr.PerillánP4-Aminopyridine causes apoptosis and blocks an outward rectifier K⁺ channel in malignant astrocytoma cell linesJ Neurosci Res.1997481227Open DOISearch in Google Scholar

[23]Ru Q, Tian X, Wu YX, Wu RH, Pi MS, Li CY. Voltage-gated and ATP-sensitive K⁺ channels are associated with cell proliferation and tumorigenesis of human glioma. Oncol Rep. 2014; 31:842–8.10.3892/or.2013.287524284968RuQTianXWuYXWuRHPiMSLiCY.Voltage-gated and ATP-sensitive K⁺ channels are associated with cell proliferation and tumorigenesis of human gliomaOncol Rep.2014318428Open DOISearch in Google Scholar

[24]Liu J, Feng S, Zhang L, Wu Z, Chen Q, Cheng W, et al. [Expression and properties of potassium channels in human mammary epithelial cell line MCF10A and its possible role in proliferation]. Sheng Li Xue Bao [Acta Physiologica Sinica]. 2010; 62:203–9. [in Chinese, English abstract].20571736LiuJFengSZhangLWuZChenQChengW[Expression and properties of potassium channels in human mammary epithelial cell line MCF10A and its possible role in proliferation]Sheng Li Xue Bao [Acta Physiologica Sinica].2010622039[in Chinese, English abstract]Search in Google Scholar

[25]Leanza L, Henry B, Sassi N, Zoratti M, Chandy KG, Gulbins E, et al. Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO Mol Med. 2012; 4:577–93.2249611710.1002/emmm.201200235LeanzaLHenryBSassiNZorattiMChandyKGGulbinsEInhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cellsEMBO Mol Med.2012457793Search in Google Scholar

[26]de Guadalupe Chávez-Lòpez M, Hernández-Gallegos E, Vázquez-Sánchez AY, Gariglio P, Camacho J. Antiproliferative and proapoptotic effects of astemizole on cervical cancer cells. Int J Gynecol Cancer. 2014; 24:824–8.10.1097/IGC.000000000000015124819656de Guadalupe Chávez-LòpezMHernández-GallegosEVázquez-SánchezAYGariglioPCamachoJ.Antiproliferative and proapoptotic effects of astemizole on cervical cancer cellsInt J Gynecol Cancer.2014248248Open DOISearch in Google Scholar

[27]Ouadid-Ahidouch H, Le Bourhis X, Roudbaraki M, Toillon RA, Delcourt P, Prevarskaya N. Changes in the K⁺ current-density of MCF-7 cells during progression through the cell cycle: possible involvement of a h.ether-á-gogo K⁺ channel. Receptors Channels. 2001; 7:345–56.Ouadid-AhidouchHLe BourhisXRoudbarakiMToillonRADelcourtPPrevarskayaN.Changes in the K⁺ current-density of MCF-7 cells during progression through the cell cycle: possible involvement of a h.ether-á-gogo K⁺ channelReceptors Channels.2001734556Search in Google Scholar

[28]Breier A, Gibalova L, Seres M, Barancik M, Sulova Z. New insight into p-glycoprotein as a drug target. Anticancer Agents Med Chem. 2013; 13:159–70.2293141310.2174/187152013804487380BreierAGibalovaLSeresMBarancikMSulovaZ.New insight into p-glycoprotein as a drug targetAnticancer Agents Med Chem.20131315970Search in Google Scholar

[29]Jahchan NS, Dudley JT, Mazur PK, Flores N, Yang D, Palmerton A, et al. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov. 2013; 3:1364–77.10.1158/2159-8290.CD-13-018324078773JahchanNSDudleyJTMazurPKFloresNYangDPalmertonAA drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumorsCancer Discov.20133136477Open DOISearch in Google Scholar

[30]García-Quiroz J, García-Becerra R, Santos-Martínez N, Barrera D, Ordaz-Rosado D, Avila E, et al. In vivo dual targeting of the oncogenic Ether-á-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors. BMC Cancer. 2014; 14:745, 10.1186/1471-2407-14-745.25280486García-QuirozJGarcía-BecerraRSantos-MartínezNBarreraDOrdaz-RosadoDAvilaEIn vivo dual targeting of the oncogenic Ether-á-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumorsBMC Cancer.20141474510.1186/1471-2407-14-745Open DOISearch in Google Scholar

[31]Venturini E. Kv1.3 inhibitors in the treatment of glioma and melanoma [doctoral dissertation]. Germany: Universität Duisburg-Essen; 2015.VenturiniE.Kv1.3 inhibitors in the treatment of glioma and melanoma [doctoral dissertation]GermanyUniversität Duisburg-Essen2015Search in Google Scholar

[32]Stone JR, Yang S. Hydrogen peroxide: a signaling messenger. Antioxid Redox Signal. 2006; 8:243–70.10.1089/ars.2006.8.24316677071StoneJRYangS.Hydrogen peroxide: a signaling messengerAntioxid Redox Signal.2006824370Open DOISearch in Google Scholar

[33]Dyugovskaya L, Lavie P, Lavie L. Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. Am J Respir Crit Care Med. 2002; 165:934–9.1193471710.1164/ajrccm.165.7.2104126DyugovskayaLLaviePLavieL.Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patientsAm J Respir Crit Care Med.20021659349Search in Google Scholar

[34]Chattopadhyay MK, Tabor CW, Tabor H. Polyamine deficiency leads to accumulation of reactive oxygen species in a spe2Δ mutant of Saccharomyces cerevisiae. Yeast. 2006; 23:751–61.10.1002/yea.1393ChattopadhyayMKTaborCWTaborH.Polyamine deficiency leads to accumulation of reactive oxygen species in a spe2Δ mutant of Saccharomyces cerevisiaeYeast.20062375161Open DOISearch in Google Scholar

[35]Hermann A, Sitdikova GF, Weiger TM. Oxidative stress and maxi calcium-activated potassium (BK) channels. Biomolecules. 2015; 5:1870–911.10.3390/biom503187026287261HermannASitdikovaGFWeigerTM.Oxidative stress and maxi calcium-activated potassium (BK) channelsBiomolecules.201551870911459877926287261Open DOISearch in Google Scholar

[36]Agostinelli E, Tempera G, Viceconte N, Saccoccio S, Battaglia V, Grancara S, et al. Potential anticancer application of polyamine oxidation products formed by amine oxidase: a new therapeutic approach. Amino Acids. 2010; 38:353–68.10.1007/s00726-009-0431-820012114AgostinelliETemperaGViceconteNSaccoccioSBattagliaVGrancaraSPotential anticancer application of polyamine oxidation products formed by amine oxidase: a new therapeutic approachAmino Acids.2010383536820012114Open DOISearch in Google Scholar

[37]Szabó I, Bock J, Grassmé H, Soddemann M, Wilker B, Lang F, et al. Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes. Proc Natl Acad Sci U S A. 2008; 105:14861–6.1881830410.1073/pnas.0804236105SzabóIBockJGrassméHSoddemannMWilkerBLangFMitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytesProc Natl Acad Sci U S A.2008105148616256745818818304Search in Google Scholar

[38]Jakhar R, Paul S, Bhardwaj M, Kang SC. Astemizole-Histamine induces Beclin-1-independent autophagy by targeting p53-dependent crosstalk between autophagy and apoptosis. Cancer Lett. 2016; 372:89–100.2673906110.1016/j.canlet.2015.12.024JakharRPaulSBhardwajMKangSC.Astemizole-Histamine induces Beclin-1-independent autophagy by targeting p53-dependent crosstalk between autophagy and apoptosisCancer Lett.20163728910026739061Search in Google Scholar

[39]Woodfork KA, Wonderlin WF, Peterson VA, Strobl JS. Inhibition of ATP-sensitive potassium channels causes reversible cell-cycle arrest of human breast cancer cells in tissue culture. J Cell Physiol. 1995; 162:163–71.782242710.1002/jcp.1041620202WoodforkKAWonderlinWFPetersonVAStroblJS.Inhibition of ATP-sensitive potassium channels causes reversible cell-cycle arrest of human breast cancer cells in tissue cultureJ Cell Physiol.1995162163717822427Search in Google Scholar

[40]Ouadid-Ahidouch H, Roudbaraki M, Delcourt P, Ahidouch A, Joury N, Prevarskaya N. Functional and molecular identification of intermediate-conductance Ca²⁺-activated K⁺ channels in breast cancer cells: association with cell cycle progression. Am J Physiol Cell Physiol. 2004; 287:C125–34.1498523710.1152/ajpcell.00488.2003Ouadid-AhidouchHRoudbarakiMDelcourtPAhidouchAJouryNPrevarskayaN.Functional and molecular identification of intermediate-conductance Ca²⁺-activated K⁺ channels in breast cancer cells: association with cell cycle progressionAm J Physiol Cell Physiol.2004287C1253414985237Search in Google Scholar

[41]Zhang P, Yang X, Yin Q, Yi J, Shen W, Zhao L, et al. Inhibition of SK4 potassium channels suppresses cell proliferation, migration and the epithelial–mesenchymal transition in triple-negative breast cancer cells. PLoS One. 2016; 11:e0154471, 10.1371/journal.pone.0154471.27124117ZhangPYangXYinQYiJShenWZhaoLInhibition of SK4 potassium channels suppresses cell proliferation, migration and the epithelial–mesenchymal transition in triple-negative breast cancer cellsPLoS One.201611e015447110.1371/journal.pone.0154471484962827124117Open DOISearch in Google Scholar