<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.0904.416_s_001_w2aab3b7b3b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Human leukocyte antigen-G (HLA-G) is a nonclassical HLA class I antigen with immunomodulatory activity that usually inhibits immune responses. The role of the HLA-G polymorphism in multidrug-resistant tuberculosis (MDR-TB) is unknown.</p></sec><sec id="j_1905-7415.0904.416_s_002_w2aab3b7b3b1b6b1aab1c16b2Aa"><h3>Objectives</h3><p>To analyze clinical data from Indonesian Javanese patients with MDR-TB to find an association between the HLA-G polymorphism and MDR-TB.</p></sec><sec id="j_1905-7415.0904.416_s_003_w2aab3b7b3b1b6b1aab1c16b3Aa"><h3>Methods</h3><p>Fifty-seven Indonesian Javanese patients with MDR-TB were enrolled and monitored from May 2012 to Jan 2014. Non-TB individuals and non-MDR-TB individuals were recruited as controls. The HLA-G polymorphism status of each patient was determined by polymerase chain reaction. Patient clinical data were analyzed against polymorphism status. The presence of an association was estimated with an odds ratio (OR) and 95% confidence interval (CI) calculated via logistic regression.</p></sec><sec id="j_1905-7415.0904.416_s_004_w2aab3b7b3b1b6b1aab1c16b4Aa"><h3>Results</h3><p>Nineteen (33.3%), 30 (52.6%), and 8 (14.1%) MDR-TB patient participants carried a homozygous deletion (D/D), heterozygous deletion (I/D), and homozygous insertion (I/I) genotypes, respectively. Among control participants, D/D genotype carriers less frequently had a history of TB infection (OR 0.4, 95% CI 0.179-0.981, P = 0.043). The deletion allele for MDR-TB patients was associated with a decreased likelihood of developing pulmonary fibrosis (adjusted OR 0.1, 95% CI 0.014-0.639, P = 0.016).</p></sec><sec id="j_1905-7415.0904.416_s_005_w2aab3b7b3b1b6b1aab1c16b5Aa"><h3>Conclusions</h3><p>D/D genotype carriers are less susceptible to TB, and MDR-TB patients with a deletion allele are less likely to develop pulmonary fibrosis.</p></sec></abstract>

BackgroundHuman leukocyte antigen-G (HLA-G) is a nonclassical HLA class I antigen with immunomodulatory activity that usually inhibits immune responses. The role of the HLA-G polymorphism in multidrug-resistant tuberculosis (MDR-TB) is unknown.ObjectivesTo analyze clinical data from Indonesian Javanese patients with MDR-TB to find an association between the HLA-G polymorphism and MDR-TB.MethodsFifty-seven Indonesian Javanese patients with MDR-TB were enrolled and monitored from May 2012 to Jan 2014. Non-TB individuals and non-MDR-TB individuals were recruited as controls. The HLA-G polymorphism status of each patient was determined by polymerase chain reaction. Patient clinical data were analyzed against polymorphism status. The presence of an association was estimated with an odds ratio (OR) and 95% confidence interval (CI) calculated via logistic regression.ResultsNineteen (33.3%), 30 (52.6%), and 8 (14.1%) MDR-TB patient participants carried a homozygous deletion (D/D), heterozygous deletion (I/D), and homozygous insertion (I/I) genotypes, respectively. Among control participants, D/D genotype carriers less frequently had a history of TB infection (OR 0.4, 95% CI 0.179-0.981, P = 0.043). The deletion allele for MDR-TB patients was associated with a decreased likelihood of developing pulmonary fibrosis (adjusted OR 0.1, 95% CI 0.014-0.639, P = 0.016).ConclusionsD/D genotype carriers are less susceptible to TB, and MDR-TB patients with a deletion allele are less likely to develop pulmonary fibrosis.

Human Leukocyte Antigen-G (HLA-G) 14-bp deletion polymorphism is associated with decreased risk of pulmonary fibrosis in Indonesian Javanese patients with multidrug-resistant tuberculosis

A-IGIC (A-Infection, Genomic, Immunology & Cancer) Research Group

Center of Biotechnology and Biodiversity Research and Development

Department of Microbiology, Faculty of Medicine

Department of Pulmonology, Faculty of Medicine

Doctoral Program of Medical Sciences Faculty of Medicine

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundHuman leukocyte antigen-G (HLA-G) is a nonclassical HLA class I antigen with immunomodulatory activity that usually inhibits immune responses. The...

Human Leukocyte Antigen-G (HLA-G) 14-bp deletion polymorphism is associated with decreased risk of pulmonary fibrosis in Indonesian Javanese patients with multidrug-resistant tuberculosis

Article Category: Brief communication (Original)

Publié en ligne: 31 janv. 2017

Pages: 473 - 479

DOI: https://doi.org/10.5372/1905-7415.0904.416

Mots clés
HLA-G, Indonesia, MDR-TB, polymorphism, tuberculosis

© 2017 Marwoto, Afiono Agung Prasetyo, Ratna Sariyatun, Suradi, Reviono, Harsini

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Human Leukocyte Antigen-G (HLA-G) 14-bp deletion polymorphism is associated with decreased risk of pulmonary fibrosis in Indonesian Javanese patients with multidrug-resistant tuberculosis

Article Category: Brief communication (Original)

Publié en ligne: 31 janv. 2017

Pages: 473 - 479

DOI: https://doi.org/10.5372/1905-7415.0904.416

Mots clésHLA-G, Indonesia, MDR-TB, polymorphism, tuberculosis

© 2017 Marwoto, Afiono Agung Prasetyo, Ratna Sariyatun, Suradi, Reviono, Harsini

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
HLA-G, Indonesia, MDR-TB, polymorphism, tuberculosis