<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The physiological role of thyreoliberin (TRH) is the preservation of homeostasis within four systems (i) the hypothalamic-hypophsysiotropic neuroendocrine system, (ii) the brain stem/midbrain/spinal cord system, (iii) the limbic/cortical system, and (iv) the chronobiological system. Thus TRH, via various cellular mechanisms, regulates a wide range of biological processes (arousal, sleep, learning, locomotive activity, mood) and possesses the potential for unique and widespread applications for treatment of human illnesses. Since the therapeutic potential of TRH is limited by its pharmacological profile (enzymatic instability, short half-life, undesirable effects), several synthetic analogues of TRH were constructed and studied in mono- or adjunct therapy of central nervous system (CNS) disturbances. The present article summarizes the current state of understanding of the physiological role of TRH and describes its putative role in clinical indications in CNS maladies with a focus on the action of TRH analogues.</p></abstract>

The physiological role of thyreoliberin (TRH) is the preservation of homeostasis within four systems (i) the hypothalamic-hypophsysiotropic neuroendocrine system, (ii) the brain stem/midbrain/spinal cord system, (iii) the limbic/cortical system, and (iv) the chronobiological system. Thus TRH, via various cellular mechanisms, regulates a wide range of biological processes (arousal, sleep, learning, locomotive activity, mood) and possesses the potential for unique and widespread applications for treatment of human illnesses. Since the therapeutic potential of TRH is limited by its pharmacological profile (enzymatic instability, short half-life, undesirable effects), several synthetic analogues of TRH were constructed and studied in mono- or adjunct therapy of central nervous system (CNS) disturbances. The present article summarizes the current state of understanding of the physiological role of TRH and describes its putative role in clinical indications in CNS maladies with a focus on the action of TRH analogues.

Tyreoliberin (Trh) – The Regulatory Neuropeptide of Cns Homeostasis

Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences

Medical Journal of Cell Biology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Tyreoliberin (Trh) \u2013 The Regulatory Neuropeptide of Cns Homeostasis"}

The physiological role of thyreoliberin (TRH) is the preservation of homeostasis within four systems (i) the hypothalamic-hypophsysiotropic neuroendocrine...

Tyreoliberin (Trh) – The Regulatory Neuropeptide of Cns Homeostasis

Publié en ligne: 15 oct. 2014

Pages: 139 - 153

DOI: https://doi.org/10.2478/v10052-010-0008-4

Mots clés
thyreoliberin, metabolism, neuromodulator, nootropic factor, analepsy, antidepressant, neuroprotection

© by Danuta Jantas

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Tyreoliberin (Trh) – The Regulatory Neuropeptide of Cns Homeostasis

Publié en ligne: 15 oct. 2014

Pages: 139 - 153

DOI: https://doi.org/10.2478/v10052-010-0008-4

Mots clésthyreoliberin, metabolism, neuromodulator, nootropic factor, analepsy, antidepressant, neuroprotection

© by Danuta Jantas

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
thyreoliberin, metabolism, neuromodulator, nootropic factor, analepsy, antidepressant, neuroprotection