<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p><italic>Highly sensitive and specific tests are needed in monitoring of the serological activity and efficacy of treatment of late latent syphilis. In a retrospective study, the data of 52 patients who had received treatment for late latent syphilis were analysed in the Clinical Centre of Skin and Sexually Transmitted Diseases, Latvia. The diagnostic sensitivity and specificity was calculated by Syphilis Immunoblot IgG, Treponema Pallidum Immobilisation Reaction (TPIR) and Syphilis Express Diagnosis (SED). The correlation between Treponema Pallidum Immobilisation Reaction (TPIR) and Syphilis Immunoblot IgG, SED and TPIR results were estimated. Syphilis Immunoblot IgG is useful for latent syphilis diagnostics. The values of the synthetic peptide TmpA, TmpN15 and TmpN47 on the Syphilis Immunoblot IgG strip are useful for monitoring of the treatment of late latent syphilis patients.</italic></p></abstract>

Highly sensitive and specific tests are needed in monitoring of the serological activity and efficacy of treatment of late latent syphilis. In a retrospective study, the data of 52 patients who had received treatment for late latent syphilis were analysed in the Clinical Centre of Skin and Sexually Transmitted Diseases, Latvia. The diagnostic sensitivity and specificity was calculated by Syphilis Immunoblot IgG, Treponema Pallidum Immobilisation Reaction (TPIR) and Syphilis Express Diagnosis (SED). The correlation between Treponema Pallidum Immobilisation Reaction (TPIR) and Syphilis Immunoblot IgG, SED and TPIR results were estimated. Syphilis Immunoblot IgG is useful for latent syphilis diagnostics. The values of the synthetic peptide TmpA, TmpN15 and TmpN47 on the Syphilis Immunoblot IgG strip are useful for monitoring of the treatment of late latent syphilis patients.

Optimised Routines for Monitoring of Treated Late Latent Syphilis Patients

Centre of Sexually Transmitted and Skin Diseases, Pauls Stradiņš Clinical Hospital, Pērnavas iela 70, Rīga, LV-1009, LATVIA

Clinical Centre of Skin and Sexually Transmitted Diseases, A. Briāna iela 2, Rīga, LV-1001, LATVIA

Children's Hospital of Rīga Stradiņš University, Vienības gatve 45, Rīga, LV-1004, LATVIA

Faculty of Medicine, University of Latvia, Šarlotes iela 1a, Rīga, LV-1001, LATVIA

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

{"article-title":"Optimised Routines for Monitoring of Treated Late Latent Syphilis Patients"}

Highly sensitive and specific tests are needed in monitoring of the serological activity and efficacy of treatment of late latent syphilis. In a retrospective...

Optimised Routines for Monitoring of Treated Late Latent Syphilis Patients

Publié en ligne: 02 avr. 2009

Pages: 209 - 214

DOI: https://doi.org/10.2478/v10046-009-0001-1

Mots clés
syphilis, serological diagnostics, treatment monitoring

This content is open access.

Optimised Routines for Monitoring of Treated Late Latent Syphilis Patients

Publié en ligne: 02 avr. 2009

Pages: 209 - 214

DOI: https://doi.org/10.2478/v10046-009-0001-1

Mots cléssyphilis, serological diagnostics, treatment monitoring

This content is open access.

Mots clés
syphilis, serological diagnostics, treatment monitoring