<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><bold>Background.</bold> The radioguided localization of occult breast lesions (ROLL) technique often utilizes iodinated radiographic contrast to assure that the local injection of 99mTc-MAA corresponds to the location of the lesion under investigation. However, for this application, this contrast has several shortcomings. The objective of this study was to evaluate the safety, effectiveness and technical feasibility of the use of polydimethylsiloxane (PDMS) as radiological contrast and tissue marker in ROLL.<bold>Materials and methods.</bold> The safety assessment was performed by the acute toxicity study in Wistar rats (n = 50). The radiological analysis of breast tissue (n = 32) from patients undergoing reductive mammoplasty was used to verify the effectiveness of PDMS as contrast media. The technical feasibility was evaluated through the scintigraphic and histologic analysis.<bold>Results.</bold> We found no toxic effects of PDMS for this use during the observational period. It has been demonstrated in human breast tissue that the average diameter of the tissue marked by PDMS was lower than when marked by the contrast medium (p &lt;0.001). PDMS did not interfere with the scintigraphic uptake (p = 0.528) and there was no injury in histological processing of samples.<bold>Conclusions.</bold> This study demonstrated not only the superiority of PDMS as radiological contrast in relation to the iodinated contrast, but also the technical feasibility for the same applicability in the ROLL.</abstract>

Background. The radioguided localization of occult breast lesions (ROLL) technique often utilizes iodinated radiographic contrast to assure that the local injection of 99mTc-MAA corresponds to the location of the lesion under investigation. However, for this application, this contrast has several shortcomings. The objective of this study was to evaluate the safety, effectiveness and technical feasibility of the use of polydimethylsiloxane (PDMS) as radiological contrast and tissue marker in ROLL.Materials and methods. The safety assessment was performed by the acute toxicity study in Wistar rats (n = 50). The radiological analysis of breast tissue (n = 32) from patients undergoing reductive mammoplasty was used to verify the effectiveness of PDMS as contrast media. The technical feasibility was evaluated through the scintigraphic and histologic analysis.Results. We found no toxic effects of PDMS for this use during the observational period. It has been demonstrated in human breast tissue that the average diameter of the tissue marked by PDMS was lower than when marked by the contrast medium (p <0.001). PDMS did not interfere with the scintigraphic uptake (p = 0.528) and there was no injury in histological processing of samples.Conclusions. This study demonstrated not only the superiority of PDMS as radiological contrast in relation to the iodinated contrast, but also the technical feasibility for the same applicability in the ROLL.

Polydimethylsiloxane: a new contrast material for localization of occult breast lesions

Research Center for Innovative Health Sciences (NUPICS), Federal University of Juiz de Fora, School of Pharmacy, Juiz de Fora, Brasil

Neuroscience Laboratory (LIM 27), Department and Institute of Psychiatry, University of São Paulo, School of Medicine, São Paulo, Brasil

Radiology and Oncology

Background. The radioguided localization of occult breast lesions (ROLL) technique often utilizes iodinated radiographic contrast to assure that the local...

Polydimethylsiloxane: a new contrast material for localization of occult breast lesions

Publié en ligne: 29 mars 2011

Pages: 166 - 173

DOI: https://doi.org/10.2478/v10019-011-0009-4

Mots clés
breast cancer, surgery, radiological contrast, ROLL technique

This content is open access.

Polydimethylsiloxane: a new contrast material for localization of occult breast lesions

Publié en ligne: 29 mars 2011

Pages: 166 - 173

DOI: https://doi.org/10.2478/v10019-011-0009-4

Mots clésbreast cancer, surgery, radiological contrast, ROLL technique

This content is open access.

Mots clés
breast cancer, surgery, radiological contrast, ROLL technique