<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The present investigation was undertaken to fabricate porous nanoparticles of metoprolol tartrate by spray-drying using ammonium carbonate as pore former. Prepared nanoparticles were coated with Eudragit S100 polymer in order to prevent the release of metoprolol tartrate in the upper GI tract. It was shown that nanoparticles with low size ranges can be obtained with a low feed inlet rate. Micromeritic studies confirmed that nanoparticle batches are discrete and free flowing. Effects of the pore former on drug loading, porosity and <italic>in vitro </italic>release were studied. It was found that there was an increase in drug loading and porosity with increasing the amount of pore former. <italic>In vitro </italic>drug release studies showed that an increase in pore former made drug release faster. Release kinetics proved that nanoparticles follow a zero-order release mechanism.</p></abstract>

The present investigation was undertaken to fabricate porous nanoparticles of metoprolol tartrate by spray-drying using ammonium carbonate as pore former. Prepared nanoparticles were coated with Eudragit S100 polymer in order to prevent the release of metoprolol tartrate in the upper GI tract. It was shown that nanoparticles with low size ranges can be obtained with a low feed inlet rate. Micromeritic studies confirmed that nanoparticle batches are discrete and free flowing. Effects of the pore former on drug loading, porosity and in vitro release were studied. It was found that there was an increase in drug loading and porosity with increasing the amount of pore former. In vitro drug release studies showed that an increase in pore former made drug release faster. Release kinetics proved that nanoparticles follow a zero-order release mechanism.

Porous nanoparticles of metoprolol tartrate produced by spray-drying: development, characterization and in vitro evaluation

Department of Pharmaceutics JSS College of Pharmacy, JSS University Sri Shivarathreeshwara Nagara Mysore-570015, India

Acta Pharmaceutica

The present investigation was undertaken to fabricate porous nanoparticles of metoprolol tartrate by spray-drying using ammonium carbonate as pore former....

Porous nanoparticles of metoprolol tartrate produced by spray-drying: development, characterization and in vitro evaluation

Publié en ligne: 06 nov. 2012

Pages: 383 - 394

DOI: https://doi.org/10.2478/v10007-012-0021-2

Mots clés
metoprolol tartrate, porous nanoparticles, spray- -drying, gel permeation chromatography

This content is open access.

Porous nanoparticles of metoprolol tartrate produced by spray-drying: development, characterization and in vitro evaluation

Publié en ligne: 06 nov. 2012

Pages: 383 - 394

DOI: https://doi.org/10.2478/v10007-012-0021-2

Mots clésmetoprolol tartrate, porous nanoparticles, spray- -drying, gel permeation chromatography

This content is open access.

Mots clés
metoprolol tartrate, porous nanoparticles, spray- -drying, gel permeation chromatography