<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Novel organometallic compounds have been prepared by complexing the fluoroquinolones, norfloxacin, ofloxacin, ciprofloxacin, sparfloxacin, lomefloxacin, pefloxacin and gatifloxacin, with bismuth. The complexes were characterized by UV, IR, atomic absorption spectroscopy, elemental analysis, differential scanning calorimetry, thermogravimetric analysis and mass spectrometry. Their antibacterial potential against <italic>Helicobacter pylori</italic> and other microorganisms was investigated. These compounds were found to possess strong activity against <italic>Helicobacter pylori</italic> with a minimum inhibitory concentration of 0.5 mg L<sup>-1</sup>. They also exhibited moderate activity against <italic>Escherichia coli, Staphylococcus aureus, Bacillus pumilus</italic> and <italic>Staphylococcus epidermidis.</italic> These bismuth-fluoroquinolone complexes have the potential to be developed as drugs against <italic>H. pylori</italic> related ailments.</p></abstract>

Novel organometallic compounds have been prepared by complexing the fluoroquinolones, norfloxacin, ofloxacin, ciprofloxacin, sparfloxacin, lomefloxacin, pefloxacin and gatifloxacin, with bismuth. The complexes were characterized by UV, IR, atomic absorption spectroscopy, elemental analysis, differential scanning calorimetry, thermogravimetric analysis and mass spectrometry. Their antibacterial potential against Helicobacter pylori and other microorganisms was investigated. These compounds were found to possess strong activity against Helicobacter pylori with a minimum inhibitory concentration of 0.5 mg L-1. They also exhibited moderate activity against Escherichia coli, Staphylococcus aureus, Bacillus pumilus and Staphylococcus epidermidis. These bismuth-fluoroquinolone complexes have the potential to be developed as drugs against H. pylori related ailments.

Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against <italic>Helicobacter pylori</italic>

Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390001, India

Laboratoire de Bacteriologie, Université Victor Segalen Bordeaux 2 and Hôpital Pellegrin, Place Amélie Raba-Léon 33076 Bordeaux cedex France

Acta Pharmaceutica

Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against 

Novel organometallic compounds have been prepared by complexing the fluoroquinolones, norfloxacin, ofloxacin, ciprofloxacin, sparfloxacin, lomefloxacin,...

Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori

Publié en ligne: 09 oct. 2009

Pages: 259 - 271

DOI: https://doi.org/10.2478/v10007-009-0027-6

Mots clés
fluorokinolon, bizmut, kompleks, antimikrobno djelovanje,

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