<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">The present study aimed to develop hydroxypropyl methylcellulose based transdermal delivery of pentazocine. In formulations containing lower proportions of polymer, the drug released followed the Higuchi kinetics while, with an increase in polymer content, it followed the zero-order release kinetics. Release exponent (<italic>n</italic>) values imply that the release of pentazocine from matrices was non-Fickian. FT-IR, DSC and XRD studies indicated no interaction between drug and polymer.The <italic>in vitro</italic> dissolution rate constant, dissolution half-life and pharmacokinetic parameters (<italic>C</italic>max, <italic>t</italic>max, <italic>AUC</italic>(s), <italic>t</italic>1/2, <italic>K</italic>el, and <italic>MRT</italic>) were evaluated statistically by two-way ANOVA. A significant difference was observed between but not within the tested products. Statistically, a good correlation was found between per cent of drug absorbed from patches <italic>vs.</italic> Cmax and <italic>AUC</italic>(s). A good correlation was also observed when per cent drug released was correlated with the blood drug concentration obtained at the same time point. The results of this study indicate that the polymeric matrix films of pentazocine hold potential for transdermal drug delivery.</abstract>

The present study aimed to develop hydroxypropyl methylcellulose based transdermal delivery of pentazocine. In formulations containing lower proportions of polymer, the drug released followed the Higuchi kinetics while, with an increase in polymer content, it followed the zero-order release kinetics. Release exponent (n) values imply that the release of pentazocine from matrices was non-Fickian. FT-IR, DSC and XRD studies indicated no interaction between drug and polymer.The in vitro dissolution rate constant, dissolution half-life and pharmacokinetic parameters (Cmax, tmax, AUC(s), t1/2, Kel, and MRT) were evaluated statistically by two-way ANOVA. A significant difference was observed between but not within the tested products. Statistically, a good correlation was found between per cent of drug absorbed from patches vs. Cmax and AUC(s). A good correlation was also observed when per cent drug released was correlated with the blood drug concentration obtained at the same time point. The results of this study indicate that the polymeric matrix films of pentazocine hold potential for transdermal drug delivery.

Development of matrix controlled transdermal delivery systems of pentazocine: <italic>In vitro/in vivo</italic> performance

Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, India

Acta Pharmaceutica

Development of matrix controlled transdermal delivery systems of pentazocine:  performance

The present study aimed to develop hydroxypropyl methylcellulose based transdermal delivery of pentazocine. In formulations containing lower proportions of...

Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance

Publié en ligne: 29 juin 2009

Pages: 171 - 186

DOI: https://doi.org/10.2478/v10007-009-0014-y

Mots clés
pentazocin, transdermalna isporuka lijekova, Cygnusov držač flastera, karakterizacija, vrednovanje

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