<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Reaction of ethyl-6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carboxylates (<bold>1a-i</bold>) with hydrazine hydrate yielded 6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carbohydrazides (<bold>2a-i</bold>). These products, on reaction with cyanogen bromide, gave 5-(5-amino-1,3,4--oxadiazol-2-yl)-6-methyl-4-aryl-3,4-dihydropyrimidin-2 (1<italic>H</italic>)-ones (<bold>3a-i</bold>). The resultant aminooxadiazolylpyrimidinones were condensed with isatin to obtain various 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin--5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2<italic>H</italic>-indol--2-ones (<bold>4a-i</bold>). These products were characterized by IR, <sup>1</sup>H NMR, mass spectra and elemental analysis. Products (<bold>4a-i</bold>) revealed promising antibacterial, antifungal and antioxidant activity.</p></abstract>

Reaction of ethyl-6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carboxylates (1a-i) with hydrazine hydrate yielded 6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carbohydrazides (2a-i). These products, on reaction with cyanogen bromide, gave 5-(5-amino-1,3,4--oxadiazol-2-yl)-6-methyl-4-aryl-3,4-dihydropyrimidin-2 (1H)-ones (3a-i). The resultant aminooxadiazolylpyrimidinones were condensed with isatin to obtain various 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin--5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol--2-ones (4a-i). These products were characterized by IR, 1H NMR, mass spectra and elemental analysis. Products (4a-i) revealed promising antibacterial, antifungal and antioxidant activity.

Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2<italic>H</italic>-indol-2-one derivatives

Department of Pharmaceutical Chemistry College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore-44, Tamil Nadu, India

Acta Pharmaceutica

Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2-indol-2-one derivatives

Reaction of ethyl-6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carboxylates (1a-i) with hydrazine hydrate yielded...

Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives

Publié en ligne: 12 mars 2008

Pages: 119 - 129

DOI: https://doi.org/10.2478/v10007-007-0050-4

Mots clés
pirimidinil oksadiazol amini, pirimidinon oksadiazolil indolinoni, antibakterijsko, antimikotsko i antioksidativno djelovanje

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