<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Handling is a form of experience which can result in physiological changes depending on the period of postnatal age when performed. There is a lot of evidence about the positive effect of neonatal handling, but a lack dealing with handling of adult rats. Behavioral changes and memory deficits are present in dementia-like disorders. In the present work, we tested whether 6 weeks lasting handling of young adult rats could revert memory impairment induced by trimethyltin (TMT) (7.5 mg/kg, intraperitoneally). Testing rats in Morris water maze revealed significant effect of TMT as well significant effect of handling. We observed improvement of spatial memory also between healthy, non-degenerated rats as well as degenerated rats, represented by shorter latency onto the platform. In our paper, we report beneficial effect of handling on spatial memory that is in compliance with published works about beneficial effect of cognitive therapy and training in patients with early stage of Alzheimer's disease and dementia.</p></abstract>

Handling is a form of experience which can result in physiological changes depending on the period of postnatal age when performed. There is a lot of evidence about the positive effect of neonatal handling, but a lack dealing with handling of adult rats. Behavioral changes and memory deficits are present in dementia-like disorders. In the present work, we tested whether 6 weeks lasting handling of young adult rats could revert memory impairment induced by trimethyltin (TMT) (7.5 mg/kg, intraperitoneally). Testing rats in Morris water maze revealed significant effect of TMT as well significant effect of handling. We observed improvement of spatial memory also between healthy, non-degenerated rats as well as degenerated rats, represented by shorter latency onto the platform. In our paper, we report beneficial effect of handling on spatial memory that is in compliance with published works about beneficial effect of cognitive therapy and training in patients with early stage of Alzheimer's disease and dementia.

Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration

Institute of Experimental Pharmacology and Toxicology

Biomedical Center Martin, Jessenius Faculty of Medicine in Martin

Department of Pharmacology, Jessenius Faculty of Medicine

Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Handling is a form of experience which can result in physiological changes depending on the period of postnatal age when performed. There is a lot of evidence...

Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration

Publié en ligne: 18 oct. 2019

Pages: 217 - 220

Reçu: 21 nov. 2017

Accepté: 17 déc. 2017

DOI: https://doi.org/10.2478/intox-2018-0020

Mots clés
trimethyltin, handling, memory, neurodegeneration

© 2018 Interdisciplinary Toxicology, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Beneficial effect of 6 weeks lasting handling of adult rats on spatial memory in experimental model of neurodegeneration

Publié en ligne: 18 oct. 2019

Pages: 217 - 220

Reçu: 21 nov. 2017

Accepté: 17 déc. 2017

DOI: https://doi.org/10.2478/intox-2018-0020

Mots cléstrimethyltin, handling, memory, neurodegeneration

© 2018 Interdisciplinary Toxicology, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
trimethyltin, handling, memory, neurodegeneration