<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The aim of this study was to describe the gross, histopathological and immunohistochemical features of non-specific reactive hepatitis (NSRH) in stray dogs. To perform this study the livers of 23 dogs of different breed and sex were used. The tissue sections were stained with hematoxylin–eosin, and immunohistochemically. The results of this work showed that NSRH was characterized by the infiltration of lymphocytes and plasma cells scattered throughout the liver parenchyma and in the portal stroma, and associated with inflammatory and non-inflammatory diseases in other organ systems. The inflammatory infiltrate of NSRH was composed of CD3+ T lymphocytes and HLA-DR+ lymphocytes, as well as IgG+ plasma cells and alpha-1-antitrypsin+ macrophages in the portal spaces and hepatic sinusoids.</p></abstract>

The aim of this study was to describe the gross, histopathological and immunohistochemical features of non-specific reactive hepatitis (NSRH) in stray dogs. To perform this study the livers of 23 dogs of different breed and sex were used. The tissue sections were stained with hematoxylin–eosin, and immunohistochemically. The results of this work showed that NSRH was characterized by the infiltration of lymphocytes and plasma cells scattered throughout the liver parenchyma and in the portal stroma, and associated with inflammatory and non-inflammatory diseases in other organ systems. The inflammatory infiltrate of NSRH was composed of CD3+ T lymphocytes and HLA-DR+ lymphocytes, as well as IgG+ plasma cells and alpha-1-antitrypsin+ macrophages in the portal spaces and hepatic sinusoids.

Immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs

Department of Morphology, Veterinary Faculty

Institute for Technological Development and Innovation in Communications

Department of Anatomía y Anatomía Patológica Comparada

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The aim of this study was to describe the gross, histopathological and immunohistochemical features of non-specific reactive hepatitis (NSRH) in stray dogs. To...

Immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs

Publié en ligne: 29 mars 2019

Pages: 61 - 72

Reçu: 05 janv. 2019

Accepté: 05 mars 2019

DOI: https://doi.org/10.2478/acve-2019-0004

Mots clés
liver, hepatitis, immunohistochemistry, dog

© 2019 Jaber Jose Raduan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Immunological and pathological investigations of non-specific reactive hepatitis in shelter dogs

Publié en ligne: 29 mars 2019

Pages: 61 - 72

Reçu: 05 janv. 2019

Accepté: 05 mars 2019

DOI: https://doi.org/10.2478/acve-2019-0004

Mots clésliver, hepatitis, immunohistochemistry, dog

© 2019 Jaber Jose Raduan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
liver, hepatitis, immunohistochemistry, dog