<abstract xmlns="http://www.w3.org/1999/xhtml">This article describes the designing of matrix tablets composed of polyethylene oxides (PEOs) with relative molecular masses of 1 × 106, 2 × 106, and 4 × 106. Percolation thresholds were determined for all of the selected PEO formulations (18, 16, and 12 %, <italic>m/m</italic>), taking into consideration excipients and tablet surface area which significantly increased the percolation threshold. Moreover, the robustness of the gel layer in PEO matrix tablets was evaluated by magnetic resonance imaging under various mechanical stresses (no flow, 12 mL min−1, and 64 mL−1 of medium flow). Correlations between the percolation threshold and gel thickness (<italic>R</italic>2 = 0.86), gel thickness and the erosion coefficient (<italic>R</italic>2 = 0.96) was detected. Furthermore, small-angle X-ray scattering of the selected PEOs detected differences in polymer molecular complexity at the nanoscale. Finally, the ratio of the heat of coalescence to the heat of fusion has confirmed the PEO molecular mass-dependent percolation threshold.</abstract>

This article describes the designing of matrix tablets composed of polyethylene oxides (PEOs) with relative molecular masses of 1 × 106, 2 × 106, and 4 × 106. Percolation thresholds were determined for all of the selected PEO formulations (18, 16, and 12 %, m/m), taking into consideration excipients and tablet surface area which significantly increased the percolation threshold. Moreover, the robustness of the gel layer in PEO matrix tablets was evaluated by magnetic resonance imaging under various mechanical stresses (no flow, 12 mL min−1, and 64 mL−1 of medium flow). Correlations between the percolation threshold and gel thickness (R2 = 0.86), gel thickness and the erosion coefficient (R2 = 0.96) was detected. Furthermore, small-angle X-ray scattering of the selected PEOs detected differences in polymer molecular complexity at the nanoscale. Finally, the ratio of the heat of coalescence to the heat of fusion has confirmed the PEO molecular mass-dependent percolation threshold.

Polyethylene oxide matrix tablet swelling evolution: The impact of molecular mass and tablet composition

Department of Pharmaceutical Technology Faculty of Pharmacy

Research Center for Pharmaceutical Engineering (RCPE)

Institute of Process and Particle Engineering

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This article describes the designing of matrix tablets composed of polyethylene oxides (PEOs) with relative molecular masses of 1 × 106, 2 × 106, and 4 × 106....

Polyethylene oxide matrix tablet swelling evolution: The impact of molecular mass and tablet composition

Publié en ligne: 04 nov. 2020

Pages: 215 - 243

Accepté: 06 juin 2020

DOI: https://doi.org/10.2478/acph-2021-0018

Mots clés
polyethylene oxide, MRI, percolation threshold, SAXS, WAXS

© 2021 Petra Draksler et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Polyethylene oxide matrix tablet swelling evolution: The impact of molecular mass and tablet composition

Publié en ligne: 04 nov. 2020

Pages: 215 - 243

Accepté: 06 juin 2020

DOI: https://doi.org/10.2478/acph-2021-0018

Mots cléspolyethylene oxide, MRI, percolation threshold, SAXS, WAXS

© 2021 Petra Draksler et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
polyethylene oxide, MRI, percolation threshold, SAXS, WAXS