<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Parkinson's disease is the second most common neurodegenerative disease, affecting about 0,15-0,3% of the world's population. Its characteristic feature is a loss of dopaminergic neurons in the substantia nigra. PD leads to dopamine deficiency and formation of intracellular inclusions called Lewy bodies, whose main ingredient is α-synuclein. Other types of nervous system cells are also affected by changes associated with that disease. The underlying molecular pathogenesis involves multiple pathways and mechanisms: mitochondrial function, oxidative stress, genetic factors, α-synuclein proteostasis, mitochondrial dynamic impairment, and disorders of the mitophagy process. This review summarizes the factors affecting the functioning of the mitochondria and their connection to the development of Parkinson's disease.</p></abstract>

Parkinson's disease is the second most common neurodegenerative disease, affecting about 0,15-0,3% of the world's population. Its characteristic feature is a loss of dopaminergic neurons in the substantia nigra. PD leads to dopamine deficiency and formation of intracellular inclusions called Lewy bodies, whose main ingredient is α-synuclein. Other types of nervous system cells are also affected by changes associated with that disease. The underlying molecular pathogenesis involves multiple pathways and mechanisms: mitochondrial function, oxidative stress, genetic factors, α-synuclein proteostasis, mitochondrial dynamic impairment, and disorders of the mitophagy process. This review summarizes the factors affecting the functioning of the mitochondria and their connection to the development of Parkinson's disease.

Dysfunction of mitochondria as the basis of Parkinson’s disease

Department of Bioenergetics, Institute of Molecular Biology and Biotechnology

Medical Journal of Cell Biology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Dysfunction of mitochondria as the basis of Parkinson\u2019s disease"}

Parkinson's disease is the second most common neurodegenerative disease, affecting about 0,15-0,3% of the world's population. Its characteristic feature is a...

Dysfunction of mitochondria as the basis of Parkinson’s disease

Publié en ligne: 03 janv. 2019

Pages: 174 - 181

Reçu: 04 nov. 2018

Accepté: 26 nov. 2018

DOI: https://doi.org/10.2478/acb-2018-0027

Mots clés
mitochondria, dysfunction, Parkinson's, disease

© 2018 Małgorzata Popis, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Dysfunction of mitochondria as the basis of Parkinson’s disease

Publié en ligne: 03 janv. 2019

Pages: 174 - 181

Reçu: 04 nov. 2018

Accepté: 26 nov. 2018

DOI: https://doi.org/10.2478/acb-2018-0027

Mots clésmitochondria, dysfunction, Parkinson's, disease

© 2018 Małgorzata Popis, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
mitochondria, dysfunction, Parkinson's, disease