<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">Myosmine [3-(1-pyrrolin-2-yl) pyridine] is an alkaloid structurally similar to nicotine, which is known to induce oxidative stress. In this study we investigated the effects of myosmine on enzymatic and non-enzymatic antioxidative defence in rat liver. Wistar rats received a single <italic>i.p.</italic> injection of 19 mg kg-1 of myosmine and an oral dose of 190 mg kg-1 by gavage. Nicotine was used as a positive control. Through either route of administration, myosmine altered the hepatic function by decreasing the levels of reduced glutathione, superoxide dismutase, and glutathione peroxidase activities on one hand and by increasing malondialdehyde, catalase, and glutathione reductase activity on the other. Compared to control, both routes caused significant lipid peroxidation in the liver and altered hepatic enzymatic and non-enzymatic antioxidative defences. The pro-oxidant effects of myosmine were comparable with those of nicotine.</abstract>

Myosmine [3-(1-pyrrolin-2-yl) pyridine] is an alkaloid structurally similar to nicotine, which is known to induce oxidative stress. In this study we investigated the effects of myosmine on enzymatic and non-enzymatic antioxidative defence in rat liver. Wistar rats received a single i.p. injection of 19 mg kg-1 of myosmine and an oral dose of 190 mg kg-1 by gavage. Nicotine was used as a positive control. Through either route of administration, myosmine altered the hepatic function by decreasing the levels of reduced glutathione, superoxide dismutase, and glutathione peroxidase activities on one hand and by increasing malondialdehyde, catalase, and glutathione reductase activity on the other. Compared to control, both routes caused significant lipid peroxidation in the liver and altered hepatic enzymatic and non-enzymatic antioxidative defences. The pro-oxidant effects of myosmine were comparable with those of nicotine.

Effects of Myosmine on Antioxidative Defence in Rat Liver

Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University, Sofia, Bulgaria

Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria

Archives of Industrial Hygiene and Toxicology

{"article-title":"Effects of Myosmine on Antioxidative Defence in Rat Liver"}

Myosmine [3-(1-pyrrolin-2-yl) pyridine] is an alkaloid structurally similar to nicotine, which is known to induce oxidative stress. In this study we...

Effects of Myosmine on Antioxidative Defence in Rat Liver

Publié en ligne: 26 mars 2012

Pages: 7 - 14

DOI: https://doi.org/10.2478/10004-1254-63-2012-2190

Mots clés
duhanski alkaloid, glodavci, lipidna peroksidacija, oksidativni stres

This content is open access.

Effects of Myosmine on Antioxidative Defence in Rat Liver

Publié en ligne: 26 mars 2012

Pages: 7 - 14

DOI: https://doi.org/10.2478/10004-1254-63-2012-2190

Mots clésduhanski alkaloid, glodavci, lipidna peroksidacija, oksidativni stres

This content is open access.

Mots clés
duhanski alkaloid, glodavci, lipidna peroksidacija, oksidativni stres