<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>This paper describes a retrospective cohort study comparing 60 workers occupationally exposed to inorganic lead and 60 matched controls. All subjects were assessed using data obtained from a specially designed Questionnaire for lead exposure and toxic effects assessment, physical examination, spirometry, ECG, and laboratory tests including blood lead level (BLL) and biomarkers of lead toxic effects. Muscle pain, droopiness, and work-related nasal symptoms were significantly more frequent in lead workers. The prevalence of lung symptoms was higher in lead workers than in controls, but not significantly (20 % vs. 6.6 %, respectively). Mean values of BLL and δ-aminolevulinic acid (ALA) were significantly higher in lead workers. The activity of δ-aminolevulinic acid dehydratase (ALAD) in lead workers was significantly lower than in controls. Abnormal of BLL, ALAD, and ALA were more frequent in lead workers, with statistical difference for BLL and ALAD. Inverse correlation was found between BLL and ALAD, and positive correlation between BLL and age, years of employment, and years of exposure. Inverse correlation was found between ALAD and age, years of employment, years of exposure, blood pressure, alcohol consumption, and years of alcohol consumption. Changes in spirometry correlated inversely with BLL. A positive correlation was found between BLL and erythrocyte count and haemoglobin concentration, whereas it was inverse for ALAD and haemoglobin concentration. A significant difference was found for BLL and ALAD, with a very high odds ratio (14.64 and 7.23, respectively) and high relative risk (4.18 and 3.08, respectively). Our data have confirmed the association between occupational lead exposure and deviation in specific biological markers of lead effect and between the role of occupational exposure in the development of adverse effects.</p></abstract>

This paper describes a retrospective cohort study comparing 60 workers occupationally exposed to inorganic lead and 60 matched controls. All subjects were assessed using data obtained from a specially designed Questionnaire for lead exposure and toxic effects assessment, physical examination, spirometry, ECG, and laboratory tests including blood lead level (BLL) and biomarkers of lead toxic effects. Muscle pain, droopiness, and work-related nasal symptoms were significantly more frequent in lead workers. The prevalence of lung symptoms was higher in lead workers than in controls, but not significantly (20 % vs. 6.6 %, respectively). Mean values of BLL and δ-aminolevulinic acid (ALA) were significantly higher in lead workers. The activity of δ-aminolevulinic acid dehydratase (ALAD) in lead workers was significantly lower than in controls. Abnormal of BLL, ALAD, and ALA were more frequent in lead workers, with statistical difference for BLL and ALAD. Inverse correlation was found between BLL and ALAD, and positive correlation between BLL and age, years of employment, and years of exposure. Inverse correlation was found between ALAD and age, years of employment, years of exposure, blood pressure, alcohol consumption, and years of alcohol consumption. Changes in spirometry correlated inversely with BLL. A positive correlation was found between BLL and erythrocyte count and haemoglobin concentration, whereas it was inverse for ALAD and haemoglobin concentration. A significant difference was found for BLL and ALAD, with a very high odds ratio (14.64 and 7.23, respectively) and high relative risk (4.18 and 3.08, respectively). Our data have confirmed the association between occupational lead exposure and deviation in specific biological markers of lead effect and between the role of occupational exposure in the development of adverse effects.

Adverse Effects in Workers Exposed to Inorganic Lead

Institute of Occupational Health, WHO Collaborating Center for Occupational Health, Skopje, Macedonia

Republic Institute for Health Protection, Skopje, Macedonia

Archives of Industrial Hygiene and Toxicology

{"article-title":"Adverse Effects in Workers Exposed to Inorganic Lead"}

This paper describes a retrospective cohort study comparing 60 workers occupationally exposed to inorganic lead and 60 matched controls. All subjects were...

Adverse Effects in Workers Exposed to Inorganic Lead

Publié en ligne: 11 avr. 2008

Pages: 19 - 29

DOI: https://doi.org/10.2478/10004-1254-59-2008-1866

Mots clés
biopokazatelji, dehidrataza delta-aminolevulinske kiseline, izloženost, olovo u krvi, toksičnost

This content is open access.

Adverse Effects in Workers Exposed to Inorganic Lead

Publié en ligne: 11 avr. 2008

Pages: 19 - 29

DOI: https://doi.org/10.2478/10004-1254-59-2008-1866

Mots clésbiopokazatelji, dehidrataza delta-aminolevulinske kiseline, izloženost, olovo u krvi, toksičnost

This content is open access.

Mots clés
biopokazatelji, dehidrataza delta-aminolevulinske kiseline, izloženost, olovo u krvi, toksičnost