<abstract xmlns="http://www.w3.org/1999/xhtml"><p>A simple method for separation of matrine and oxymatrine from Sophora flavescens was developed with cation exchange resin coupled with macroporous resin. Based on the adsorption characteristics of matrine and oxymatrine, 001×732 cation exchange resin was used to absorb target alkaloids for removing most of the foreign matter, while BS-65 macroporous resin was chosen to purify these alkaloids. The result showed that the equilibrium adsorption data of matrine and oxymatrine on 001×732 resin and BS-65 resin at 30°C was fitted to Langmuir isotherm and Freundlich isotherm, respectively. The contents of matrine and oxymatrine were increased from 0.73% and 2.2% in the crude extract of the root of Sophora flavescens to 67.2% and 66.8% in the final eluent products with the recoveries of 90.3% and 86.9%, respectively.</p></abstract>

A simple method for separation of matrine and oxymatrine from Sophora flavescens was developed with cation exchange resin coupled with macroporous resin. Based on the adsorption characteristics of matrine and oxymatrine, 001×732 cation exchange resin was used to absorb target alkaloids for removing most of the foreign matter, while BS-65 macroporous resin was chosen to purify these alkaloids. The result showed that the equilibrium adsorption data of matrine and oxymatrine on 001×732 resin and BS-65 resin at 30°C was fitted to Langmuir isotherm and Freundlich isotherm, respectively. The contents of matrine and oxymatrine were increased from 0.73% and 2.2% in the crude extract of the root of Sophora flavescens to 67.2% and 66.8% in the final eluent products with the recoveries of 90.3% and 86.9%, respectively.

Separation of matrine and oxymatrine from <italic>Sophora flavescens</italic> extract through cation exchange resin coupled with macroporous absorption resin

First Affiliated Hospital of Shantou University Medical College, Department of Pharmacy, Shantou 515041, China

Guangdong Pharmaceutical University, College of Pharmacy, Guangzhou 510006, China

Polish Journal of Chemical Technology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Separation of matrine and oxymatrine from  extract through cation exchange resin coupled with macroporous absorption resin

A simple method for separation of matrine and oxymatrine from Sophora flavescens was developed with cation exchange resin coupled with macroporous resin. Based...

Separation of matrine and oxymatrine from Sophora flavescens extract through cation exchange resin coupled with macroporous absorption resin

Publié en ligne: 30 juin 2016

Pages: 31 - 39

DOI: https://doi.org/10.1515/pjct-2016-0026

Mots clés
BS-65 macroporous resin, 001×732 cation exchange resin, separation, alkaloids

© 2016 Haohao Chen et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Separation of matrine and oxymatrine from Sophora flavescens extract through cation exchange resin coupled with macroporous absorption resin

Publié en ligne: 30 juin 2016

Pages: 31 - 39

DOI: https://doi.org/10.1515/pjct-2016-0026

Mots clésBS-65 macroporous resin, 001×732 cation exchange resin, separation, alkaloids

© 2016 Haohao Chen et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
BS-65 macroporous resin, 001×732 cation exchange resin, separation, alkaloids