<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The pharmacokinetics of doxycycline was investigated in force-fed and normally fed ducks after single intravenous (i.v.) and oral (p.o.) administration at a dose of 15 mg/kg bw. Serum concentrations of the drug were determined by the HPLC method. Pharmacokinetic parameters were calculated using compartmental analysis. Serum concentrations of doxycycline after i.v. administration in both groups were not statistically different. The values of half-lives were 5.82±1.85 h and 6.06±5.51 h in normal and force-fed birds. The total body clearance was respectively 0.40±0.05 L/h/kg and 0.34±0.10 L/h/kg, and volume of distribution (V<sub>ss</sub>) was 2.80±0.85 L/kg and 2.18±0.89 L/kg. After p.o. administraton the maximum serum levels in the control group were 0.70±0.12 μg/mL and in force-fed birds were 1.93±0.32 μg/mL, measured at 2.95±0.60 h and 1.45±0.24 h, respectively. The values of absolute bioavailability were 18.89±6.48% and 37.58±13.63%. Longer doxycycline retention in force-fed ducks was registered. Our data can be accepted as an information for possible prolonged retention of doxycycline in force fed ducks compared to normally fed ones.</p></abstract>

The pharmacokinetics of doxycycline was investigated in force-fed and normally fed ducks after single intravenous (i.v.) and oral (p.o.) administration at a dose of 15 mg/kg bw. Serum concentrations of the drug were determined by the HPLC method. Pharmacokinetic parameters were calculated using compartmental analysis. Serum concentrations of doxycycline after i.v. administration in both groups were not statistically different. The values of half-lives were 5.82±1.85 h and 6.06±5.51 h in normal and force-fed birds. The total body clearance was respectively 0.40±0.05 L/h/kg and 0.34±0.10 L/h/kg, and volume of distribution (Vss) was 2.80±0.85 L/kg and 2.18±0.89 L/kg. After p.o. administraton the maximum serum levels in the control group were 0.70±0.12 μg/mL and in force-fed birds were 1.93±0.32 μg/mL, measured at 2.95±0.60 h and 1.45±0.24 h, respectively. The values of absolute bioavailability were 18.89±6.48% and 37.58±13.63%. Longer doxycycline retention in force-fed ducks was registered. Our data can be accepted as an information for possible prolonged retention of doxycycline in force fed ducks compared to normally fed ones.

Pharmacokinetics of Doxycycline in Ducks with Steatosis due to Force-feeding

Department of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine

Macedonian Veterinary Review

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Pharmacokinetics of Doxycycline in Ducks with Steatosis due to Force-feeding"}

The pharmacokinetics of doxycycline was investigated in force-fed and normally fed ducks after single intravenous (i.v.) and oral (p.o.) administration at a...

Pharmacokinetics of Doxycycline in Ducks with Steatosis due to Force-feeding

Publié en ligne: 15 oct. 2016

Pages: 219 - 224

Reçu: 14 avr. 2016

Accepté: 31 mai 2016

DOI: https://doi.org/10.1515/macvetrev-2016-0086

Mots clés
doxycycline, ducks, force-feeding, pharmacokinetics

© 2016 Neno Bratoev et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Pharmacokinetics of Doxycycline in Ducks with Steatosis due to Force-feeding

Publié en ligne: 15 oct. 2016

Pages: 219 - 224

Reçu: 14 avr. 2016

Accepté: 31 mai 2016

DOI: https://doi.org/10.1515/macvetrev-2016-0086

Mots clésdoxycycline, ducks, force-feeding, pharmacokinetics

© 2016 Neno Bratoev et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
doxycycline, ducks, force-feeding, pharmacokinetics