[Arneson W, Brickell J. (2007). Assessment of liver function. In Clinical Chemistry: A laboratory Perspective. 1st ed. Philadelphia: F.A. Davis, Davis Company pp. 233–66.]Search in Google Scholar
[Asiedu-Gyekye IJ, Seidu MA, Awortwe C, Nyarko AK. (2014). Preliminary Safety assessment of polyhexamethylene guanidine hydrochloride. Int J Toxicol33(6): 523–31.]Search in Google Scholar
[Broxton P, Woodcock PM, Gilbert P. (1984). Binding of some polyhexamethylene biguanides to the cell envelope of Escherichia coli ATCC 8739. Microbios41(163): 15–22.]Search in Google Scholar
[Broxton P, Woodcock PM, Heatley F, Gilbert P. (1984). Interaction of some polyhexamethylene biguanides and membrane phospholipids in Escherichia coli. J Appl Bacteriol57(1): 115–124.]Search in Google Scholar
[Burger RM, Franco RJ, Drlica K. (1994). Killing Acanthamoebae with polyaminopropyl biguanide: quantitation and kinetics. Antimicrob Agents Chemother38(4): 886–888.]Search in Google Scholar
[European medicine guidelines (EMA). (2010). Guidelines on repeated dose toxicity, Committee for human medicinal products (CHMP).]Search in Google Scholar
[Friedman LS, Keefe EB. (2012). A Handbook of Liver diseases, Approach to the patient with abnormal liver biochemical and function tests. Third Edition, pp. 20–50. ISBN-9781437717259.]Search in Google Scholar
[Gilbert P, Pemberton D, Wilkinson DE. (1990). Synergism within polyhexamethylene biguanide biocide formulations. J Appl Bacteriol69(4): 593–598.]Search in Google Scholar
[Greaves P. (2007). Histopathology of preclinical toxicity studies: Interpretation and Relevance in Drug Safety Evaluation. 3rd ed. New York Academic Press.]Search in Google Scholar
[Hala A, Mohammada, Mohammad T, Abdulfttaha, AO, Abdulazeza AM, Mahmoud RME. (2014). A study of electrolyte disturbances in patients with chronic stable asthma and with asthma attacks. Egyptian Journal of Chest Diseases and Tuberculosis63(3): 529–534.]Search in Google Scholar
[Hiti K, Walochnik J, Haller-Schober EM, Faschinger C, Aspock H. (2002). Viability of Acanthamoeba after exposure to a multipurpose disinfecting contact lens solution and two hydrogen peroxide systems. Br J Ophthalmol86(2): 144–146.]Search in Google Scholar
[Hughes R, Heaselgrave W, Kilvington S. (2003). Acanthamoeba polyphaga strain age and method of cyst production influence the observed efficacy of therapeutic agents and contact lens disinfectants. Antimicrob Agents Chemother47(10): 3080–3084.]Search in Google Scholar
[Ikeda T, Ledwith A, Bamford CH, Hann RA. (1984). Interaction of a polymeric biguanide biocide with phospholipids membranes. Biochem Biophys Acta769(1): 57–66.]Search in Google Scholar
[Jusmita D, Dilutpal S, Rahul S. (2015). Oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients: A clinical approach. Asian Journal of Medical Sciences6(5): 26–30.]Search in Google Scholar
[Kang S, Wanapat M, Phesatcha K, Norrapoke T. (2015). Effect of protein level and urea in concentrate mixture on feed intake and rumen fermentation in swamp buffaloes fed rice straw-based diet. Trop Anim Health Prod47(4): 671–9.]Search in Google Scholar
[Kim JY, Kim HH, Cho KH. (2013). Acute cardiovascular toxicity of sterilizers, PHMG, and PGH: severe inflammation in human cells and heart failure in zebrafish. Cardiovasc Toxicol13(2): 148–60.]Search in Google Scholar
[Kramer A, Roth B, Muller G, Rudolph P, Klocker N. (2004). Influence of the antiseptic agents polyhexanide and octenidine on FL cells and on healing of experimental superficial aseptic wounds in piglets. A double-blind, randomized, stratified, controlled, parallel-group study. Skin Pharmacol Physiol17(3): 141–146.]Search in Google Scholar
[Lee HB, Blaufox MD. (1985). Blood volume in the rat. The Journal of Nuclear Medicine25: 72–76.]Search in Google Scholar
[Lee JE, Oum BS, Choi HY, Yu HS, Lee JS. (2007). Cysticidal effect on acanthamoeba and toxicity on human keratocytes by polyhexamethylene biguanide and chlorhexidine. Cornea26(6): 736–41.]Search in Google Scholar
[Organization for Economic Cooperation and Development (OECD) Guidelines. (2001). Guidelines for Testing of Chemicals: Acute Oral Toxicity-fixed Dose Procedure, pp. 420.]Search in Google Scholar
[Ostapenko YN, Brusin KM, Zobnin YV, Shchupak AY, Vishnevetskiy MK, Sentsov VG, Novikova OV, Alekseenko SA, Lebedko OA, Puchkov YB. (2011). Acute cholestatic liver injury caused by polyhexamethyleneguanidine hydrochloride admixed to ethyl alcohol. Crit Care Toxicol49(6): 471–477.]Search in Google Scholar
[Polat ZA, Walochnik J, Obwaller A, Vural A, Dursun A, Arici MK. (2013). Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis. Clin Experiment Ophthalmol42(2): 151–8.]Search in Google Scholar
[Romanowski EG, Yates KA, O’Connor KE, Mah FS, Shanks RM, Kowalski RP. (2013). Evaluation of polyhexamethylene biguanide (PHMB) as a disinfectant for adenovirus. JAMA Ophthalmol131(4): 495–8.]Search in Google Scholar
[Schnuch A, Geier J, Uter W, Basketter DA, Jowsey IR. (2007). The biocide polyhexamethylene biguanide remains an uncommon contact allergen. Contact Dermatitis56(4): 235–9.]Search in Google Scholar
[Taconic Technical Library. (2003). Hematological Clinical Chemistry values Sprague-Dawley rats.]Search in Google Scholar
[Welk A, Splieth CH, Schmidt-Martens G, Schwahn Ch, Kocher T, Kramer A, Rosin M. (2005). The effect of a polyhexamethylene biguanide mouth-rinse compared with a triclosan rinse and a chlorhexidine rinse on bacterial counts and 4-day plaque re-growth. J Clin Periodontol32(5): 499–505.10.1111/j.1600-051X.2005.00702.x15842266]Search in Google Scholar
[WHO. (2000). General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine, Geneva, pp.80.]Search in Google Scholar
[Wright JB, Lam K, Olson ME, Burrell RE. (2003). Is antimicrobial efficacy sufficient? A question concerning the benefits of new dressings. Wounds15(5): 133–142.]Search in Google Scholar
