<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Neurodegenerative disorders are commonly encountered in medical practices. Such diseases can lead to major morbidity and mortality among the affected individuals. The molecular pathogenesis of these disorders is not yet clear. Recent literature has revealed that mutations in RNA-binding proteins are a key cause of several human neuronal-based diseases. This review discusses the role of RNA metabolism in neurological diseases with specific emphasis on roles of RNA translation and microRNAs in neurodegeneration, RNA-mediated toxicity, repeat expansion diseases and RNA metabolism, molecular pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia, and neurobiology of survival motor neuron (SMN) and spinal muscular atrophy.</p></abstract>

Neurodegenerative disorders are commonly encountered in medical practices. Such diseases can lead to major morbidity and mortality among the affected individuals. The molecular pathogenesis of these disorders is not yet clear. Recent literature has revealed that mutations in RNA-binding proteins are a key cause of several human neuronal-based diseases. This review discusses the role of RNA metabolism in neurological diseases with specific emphasis on roles of RNA translation and microRNAs in neurodegeneration, RNA-mediated toxicity, repeat expansion diseases and RNA metabolism, molecular pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia, and neurobiology of survival motor neuron (SMN) and spinal muscular atrophy.

The role of RNA metabolism in neurological diseases

Department of Neurosurgery, University of Calgary, Calgary, Alberta,

Division of Neurosurgery, Department of Surgery, King Saud University, Riyadh,

College of Medicine, Alfaisal University, Riyadh,

Balkan Journal of Medical Genetics

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

{"article-title":"The role of RNA metabolism in neurological diseases"}

Neurodegenerative disorders are commonly encountered in medical practices. Such diseases can lead to major morbidity and mortality among the affected...

The role of RNA metabolism in neurological diseases

Article Category: Review

Publié en ligne: 09 juil. 2016

Pages: 5 - 14

DOI: https://doi.org/10.1515/bjmg-2015-0080

Mots clés
Amyotrophic lateral sclerosis, Frontotemporal dementia, RNA, Survival motor neuron (SMN), Spinal muscular atrophy

© 2016 Walter de Gruyter GmbH, Berlin/Boston

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

The role of RNA metabolism in neurological diseases

Article Category: Review

Publié en ligne: 09 juil. 2016

Pages: 5 - 14

DOI: https://doi.org/10.1515/bjmg-2015-0080

Mots clésAmyotrophic lateral sclerosis, Frontotemporal dementia, RNA, Survival motor neuron (SMN), Spinal muscular atrophy

© 2016 Walter de Gruyter GmbH, Berlin/Boston

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Mots clés
Amyotrophic lateral sclerosis, Frontotemporal dementia, RNA, Survival motor neuron (SMN), Spinal muscular atrophy