<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.0902.380_s_004_s_001_w2aab3b7b3b1b6b1aab1c16b1Aa"><h3>Background</h3><p>The relationship between endothelial dysfunction, a risk factor for coronary artery disease, and the incidence of cardiovascular disease (CVD) in the general population is not well known.</p></sec><sec id="j_1905-7415.0902.380_s_004_s_002_w2aab3b7b3b1b6b1aab1c16b2Aa"><h3>Objectives</h3><p>To determine the utility of an exercise treadmill test (ETT) combined with inflammatory markers to show endothelial dysfunction for individuals with a low risk of adverse cardiovascular (CV) events.</p></sec><sec id="j_1905-7415.0902.380_s_004_s_003_w2aab3b7b3b1b6b1aab1c16b3Aa"><h3>Methods</h3><p>Biomarkers of inflammation (lipoprotein-related phospholipase A<sub>2</sub> (Lp-PLA<sub>2</sub>) and high-sensitive C-reactive protein (hs-CRP)) and biomarkers of endothelial dysfunction (nitric oxide, oxidized low-density lipoprotein (Ox-LDL), and sialic acid) were assessed in 60 apparently healthy patients with a positive (+) or negative (−) ETT and across endothelial function assessed by flow mediated dilatation (FMD) and Lp-PLA<sub>2</sub> tertiles.</p></sec><sec id="j_1905-7415.0902.380_s_004_s_004_w2aab3b7b3b1b6b1aab1c16b4Aa"><h3>Results</h3><p>Lp-PLA<sub>2</sub> levels were increased in ETT (−) compared with ETT (+) patients. Half of ETT (−) patients were found to have levels of Lp-PLA<sub>2</sub> in the highest tertile. There was a significant inverse relationship between ETT and inflammatory biomarkers when adjusted for age, Lp-PLA<sub>2</sub> (<italic>r</italic> = −0.28, <italic>P</italic> = 0.04), or hs-CRP (<italic>r</italic> = −0.35, <italic>P</italic> = 0.01). No differences were found for biomarkers of endothelial dysfunction. All variables were reassessed across FMD tertiles. Total lipids, Ox-LDL, triglyceride, and Lp-PLA<sub>2</sub> were higher for the lowest FMD tertile.</p></sec><sec id="j_1905-7415.0902.380_s_004_s_005_w2aab3b7b3b1b6b1aab1c16b5Aa"><h3>Conclusion</h3><p>The elevation of Lp-PLA<sub>2</sub> in ETT (−) patients and the inverse relationship with inflammatory biomarkers, suggest that ETT cannot address endothelial dysfunction for individuals with apparently low risk of adverse CV events, and cannot be used for risk stratification of the general population.</p></sec></abstract>

BackgroundThe relationship between endothelial dysfunction, a risk factor for coronary artery disease, and the incidence of cardiovascular disease (CVD) in the general population is not well known.ObjectivesTo determine the utility of an exercise treadmill test (ETT) combined with inflammatory markers to show endothelial dysfunction for individuals with a low risk of adverse cardiovascular (CV) events.MethodsBiomarkers of inflammation (lipoprotein-related phospholipase A2 (Lp-PLA2) and high-sensitive C-reactive protein (hs-CRP)) and biomarkers of endothelial dysfunction (nitric oxide, oxidized low-density lipoprotein (Ox-LDL), and sialic acid) were assessed in 60 apparently healthy patients with a positive (+) or negative (−) ETT and across endothelial function assessed by flow mediated dilatation (FMD) and Lp-PLA2 tertiles.ResultsLp-PLA2 levels were increased in ETT (−) compared with ETT (+) patients. Half of ETT (−) patients were found to have levels of Lp-PLA2 in the highest tertile. There was a significant inverse relationship between ETT and inflammatory biomarkers when adjusted for age, Lp-PLA2 (r = −0.28, P = 0.04), or hs-CRP (r = −0.35, P = 0.01). No differences were found for biomarkers of endothelial dysfunction. All variables were reassessed across FMD tertiles. Total lipids, Ox-LDL, triglyceride, and Lp-PLA2 were higher for the lowest FMD tertile.ConclusionThe elevation of Lp-PLA2 in ETT (−) patients and the inverse relationship with inflammatory biomarkers, suggest that ETT cannot address endothelial dysfunction for individuals with apparently low risk of adverse CV events, and cannot be used for risk stratification of the general population.

Comparison of exercise treadmill test, flow mediated dilatation, and inflammation in individuals with low risk of adverse cardiovascular events

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundThe relationship between endothelial dysfunction, a risk factor for coronary artery disease, and the incidence of cardiovascular disease (CVD) in the...

Comparison of exercise treadmill test, flow mediated dilatation, and inflammation in individuals with low risk of adverse cardiovascular events

Article Category: Brief communication (Original)

Publicado en línea: 31 ene 2017

Páginas: 147 - 154

DOI: https://doi.org/10.5372/1905-7415.0902.380

Palabras clave
Endothelial dysfunction, ETT, exercise treadmill testing, lipoprotein related phospholipase-2, LP-PLA, vascular inflammation

© 2017 Muhammed Sait Toprak, Zeynep Gungor Ozturk, Ozlem Balci Ekmekci, Hakan Ekmekci, Baris Ikitimur, Bilgehan Karadag, Huseyin Altug Cakmak, Baris Ilerigelen, Huseyin Sonmez

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Comparison of exercise treadmill test, flow mediated dilatation, and inflammation in individuals with low risk of adverse cardiovascular events

Article Category: Brief communication (Original)

Publicado en línea: 31 ene 2017

Páginas: 147 - 154

DOI: https://doi.org/10.5372/1905-7415.0902.380

Palabras claveEndothelial dysfunction, ETT, exercise treadmill testing, lipoprotein related phospholipase-2, LP-PLA, vascular inflammation

© 2017 Muhammed Sait Toprak, Zeynep Gungor Ozturk, Ozlem Balci Ekmekci, Hakan Ekmekci, Baris Ikitimur, Bilgehan Karadag, Huseyin Altug Cakmak, Baris Ilerigelen, Huseyin Sonmez

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
Endothelial dysfunction, ETT, exercise treadmill testing, lipoprotein related phospholipase-2, LP-PLA, vascular inflammation