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Digitalisation remains a complex process in terms of integration into healthcare, a significant challenge worldwide. This study aims to identify the most influential trends in terms of authors, sources, countries, affiliations, and highly engaged documents that significantly contribute to the healthcare system’s digitalisation. To perform a comprehensive science mapping analysis, a logical data frame of 336 Web of Science database recent papers published between 2018 and 2022 are analysed using R-Bibliometrix. Our results highlighted throughout a scientific mapping and visual framework that digitalisation of the health-care system is a revolutionary, actual, and pervasive concept, considered a new research area recognised by evolution and consistent growth. Moreover, the results provide different types of networks and highlight the keywords, authors, documents, and countries with the highest interest in the subject of the digitalisation of healthcare.