<abstract xmlns="http://www.w3.org/1999/xhtml"><p>This paper addresses the issue of the stability of lists of genes identified as differentially expressed in microarray experiments. The similarities be- tween gene rankings yielded by various gene selection methods performed with resampled datasets were assessed. The mean percentage of overlapping genes for two rankings varied from 10 to 90% depending on the applied gene selection method and the size of the list. The assessment of the stability of obtained gene rankings seems to be relevant in the analysis of microarray data.</p></abstract>

This paper addresses the issue of the stability of lists of genes identified as differentially expressed in microarray experiments. The similarities be- tween gene rankings yielded by various gene selection methods performed with resampled datasets were assessed. The mean percentage of overlapping genes for two rankings varied from 10 to 90% depending on the applied gene selection method and the size of the list. The assessment of the stability of obtained gene rankings seems to be relevant in the analysis of microarray data.

The Stability of Gene Selection in Microarray Experiments

Department of Theoretical Backgrounds of Biomedical Science and Medical Informatics, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Poland

Studies in Logic, Grammar and Rhetoric

{"article-title":"The Stability of Gene Selection in Microarray Experiments"}

This paper addresses the issue of the stability of lists of genes identified as differentially expressed in microarray experiments. The similarities be- tween...

The Stability of Gene Selection in Microarray Experiments

Publicado en línea: 31 dic 2013

Páginas: 87 - 101

DOI: https://doi.org/10.2478/slgr-2013-0040

This content is open access.