<abstract xmlns="http://www.w3.org/1999/xhtml"> We present an overview of protein and peptide compounds confiscated in Denmark from late 2007 till late 2013 together with a description of a newly developed HRAM-LC-MS method used for identification. As examples of identification, we present data for the peptides AOD-9604, [D-Ala2, Gln8, Ala15, Leu27]sermorelin and the protein follistatin. It was found that a method with minimum sample preparation could be implemented for all of the confiscated peptides and the protein somatropin. However, for the protein follistatin it was necessary to include trypsin digestion in the sample preparation, which considerably increases the overall analysis time.</abstract>

We present an overview of protein and peptide compounds confiscated in Denmark from late 2007 till late 2013 together with a description of a newly developed HRAM-LC-MS method used for identification. As examples of identification, we present data for the peptides AOD-9604, [D-Ala2, Gln8, Ala15, Leu27]sermorelin and the protein follistatin. It was found that a method with minimum sample preparation could be implemented for all of the confiscated peptides and the protein somatropin. However, for the protein follistatin it was necessary to include trypsin digestion in the sample preparation, which considerably increases the overall analysis time.

Identification of peptide and protein doping related drug compounds confiscated in Denmark between 2007-2013

Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences University of Copenhagen, Frederik V’s Vej 11, 2100 Copenhagen, Denmark

Scandinavian Journal of Forensic Science

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

We present an overview of protein and peptide compounds confiscated in Denmark from late 2007 till late 2013 together with a description of a newly developed...

Identification of peptide and protein doping related drug compounds confiscated in Denmark between 2007-2013

Publicado en línea: 03 mar 2015

Páginas: 42 - 49

DOI: https://doi.org/10.2478/sjfs-2014-0003

Palabras clave
Black market drugs, doping, screening, peptides, hormones, proteins, mass spectrometry, high-resolution MS

© Danish Society of Forensic Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Identification of peptide and protein doping related drug compounds confiscated in Denmark between 2007-2013

Publicado en línea: 03 mar 2015

Páginas: 42 - 49

DOI: https://doi.org/10.2478/sjfs-2014-0003

Palabras claveBlack market drugs, doping, screening, peptides, hormones, proteins, mass spectrometry, high-resolution MS

© Danish Society of Forensic Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
Black market drugs, doping, screening, peptides, hormones, proteins, mass spectrometry, high-resolution MS