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<p> The objective of this study was the morphological and structural characterisation of glioblastoma multiforme grown in ovo. Glioma cells U87 and U118 were implanted in the chorioallantoic membrane (CAM) of chicken egg. After 10 days of incubation, tumours were resected for further analyses. Culturing two types of glioblastoma tumours from U87 and U118 cell lines has shown a number of differences in their morphology, histology, and ultrastructure. CAM assay proved to be a useful tool for studying glioblastoma growth. The model provides an excellent alternative to current rodent models and could serve as a preclinical screening assay for anticancer molecules. It might increase the speed and efficacy of the development of new drugs for the treatment of glioblastoma.</p>
</abstract>

The objective of this study was the morphological and structural characterisation of glioblastoma multiforme grown in ovo. Glioma cells U87 and U118 were implanted in the chorioallantoic membrane (CAM) of chicken egg. After 10 days of incubation, tumours were resected for further analyses. Culturing two types of glioblastoma tumours from U87 and U118 cell lines has shown a number of differences in their morphology, histology, and ultrastructure. CAM assay proved to be a useful tool for studying glioblastoma growth. The model provides an excellent alternative to current rodent models and could serve as a preclinical screening assay for anticancer molecules. It might increase the speed and efficacy of the development of new drugs for the treatment of glioblastoma.

Comparison of tumour morphology and structure from U87 and U118 glioma cells cultured on chicken embryo chorioallantoic membrane

Faculty of Animal Science, Division of Nanobiotechnology

Department of Veterinary Clinical and Animal Sciences

Journal of Veterinary Research

The objective of this study was the morphological and structural characterisation of glioblastoma multiforme grown in ovo. Glioma cells U87 and U118 were...

Comparison of tumour morphology and structure from U87 and U118 glioma cells cultured on chicken embryo chorioallantoic membrane

Publicado en línea: 31 dic 2013

Páginas: 593 - 598

DOI: https://doi.org/10.2478/bvip-2013-0101

This content is open access.