<abstract xmlns="http://www.w3.org/1999/xhtml"><p> This study reports on variations at the mitochondrial DNA (mtDNA) hypervariable region 1 (HVR-1) and at seven Y-chromosome microsatellites in an African-American population sample from Chicago, IL, USA. Our results support the hypothesis that the population studied had undergone a European malebiased gene flow. We show that comparisons of intraand inter-population diversity parameters between African-Americans, Europeans and Africans may help detect sex-biased gene flow, providing a complement to quantitative methods to estimate genetic admixture.</p></abstract>

This study reports on variations at the mitochondrial DNA (mtDNA) hypervariable region 1 (HVR-1) and at seven Y-chromosome microsatellites in an African-American population sample from Chicago, IL, USA. Our results support the hypothesis that the population studied had undergone a European malebiased gene flow. We show that comparisons of intraand inter-population diversity parameters between African-Americans, Europeans and Africans may help detect sex-biased gene flow, providing a complement to quantitative methods to estimate genetic admixture.

Detecting Sex-Biased Gene Flow in African-americans Through the Analysis of Intra- and Inter-Population Variation at Mitochondrial DNA and Y- Chromosome Microsatellites

Dipartimento di Biologia Ambientale, Università “La Sapienza”, Roma, Italia

Istituto Italiano di Antropologia, Roma, Italia

Istituto di Medicina Legale, Università Cattolica, Roma, Italia

Dipartimento di Biologia e Biotecnologie “Charles Darwin”, Università “La Sapienza”, Roma, Italia

Balkan Journal of Medical Genetics

This study reports on variations at the mitochondrial DNA (mtDNA) hypervariable region 1 (HVR-1) and at seven Y-chromosome microsatellites in an...

Detecting Sex-Biased Gene Flow in African-americans Through the Analysis of Intra- and Inter-Population Variation at Mitochondrial DNA and Y- Chromosome Microsatellites

Publicado en línea: 02 abr 2013

Páginas: 7 - 34

DOI: https://doi.org/10.2478/bjmg-2013-0001

This content is open access.