<abstract xmlns="http://www.w3.org/1999/xhtml"><p>In this article, we analyse the process of the emergence of RNA polynucleotides located in an enclosed environment, at an early stage of the RNA world. Therefore we prepared a mathematical model, composed of a set of differential equations, which simulates the behaviour of an early biological system bounded by a protocell membrane. There is evidence that enclosed environments were available on the primordial Earth. There are also experimental proofs that RNA strands can develop in these formations. The proposed model allows analysis of the influence of membrane permeability on the composition of internal material. It takes into account phenomena that lead to the elongation of an RNA strand (ligation), fission of molecules (phosphodiester bond breakage) and replication of polynucleotides. Results obtained from the model point out that the existence of protocells might support concentration of material and creation of longer molecules.</p></abstract>

In this article, we analyse the process of the emergence of RNA polynucleotides located in an enclosed environment, at an early stage of the RNA world. Therefore we prepared a mathematical model, composed of a set of differential equations, which simulates the behaviour of an early biological system bounded by a protocell membrane. There is evidence that enclosed environments were available on the primordial Earth. There are also experimental proofs that RNA strands can develop in these formations. The proposed model allows analysis of the influence of membrane permeability on the composition of internal material. It takes into account phenomena that lead to the elongation of an RNA strand (ligation), fission of molecules (phosphodiester bond breakage) and replication of polynucleotides. Results obtained from the model point out that the existence of protocells might support concentration of material and creation of longer molecules.

Mathematical modelling of molecule evolution in protocells

Institute of Informatics Silesian University of Technology, Akademicka 16, 44-100 Gliwice, Poland

International Journal of Applied Mathematics and Computer Science

{"article-title":"Mathematical modelling of molecule evolution in protocells"}

In this article, we analyse the process of the emergence of RNA polynucleotides located in an enclosed environment, at an early stage of the RNA world....

Mathematical modelling of molecule evolution in protocells

Publicado en línea: 26 mar 2013

Páginas: 213 - 229

DOI: https://doi.org/10.2478/amcs-2013-0017

This content is open access.