[1. Janssens V, Goris J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J. 2001; 353(Pt 3):417-39.10.1042/bj3530417]Search in Google Scholar
[2. Janssens V, Goris J, Van Hoof C. PP2A: the expected tumor suppressor. Curr Opin Genet Dev. 2005; 15: 34-41.10.1016/j.gde.2004.12.004]Search in Google Scholar
[3. Schonthal AH. Role of serine/threonine protein phosphatase 2A in cancer. Cancer Lett.2001; 170:1-13.10.1016/S0304-3835(01)00561-4]Search in Google Scholar
[4. Lubert EJ, Sarge KD. Interaction between protein phosphatase 2A and members of the importin beta superfamily. Biochem Biophys Res Commun. 2003; 303:908-13.10.1016/S0006-291X(03)00434-0]Search in Google Scholar
[5. Lad C, Williams NH, Wolfenden R. The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases. Proc Natl Acad Sci USA. 2003; 100:5607-10.10.1073/pnas.0631607100]Search in Google Scholar
[6. Virshup DM. Protein phosphatase 2A: a panoply of enzymes. Curr Opin Cell Biol. 2000; 12:180-5.10.1016/S0955-0674(99)00074-5]Open DOISearch in Google Scholar
[7. Eichhorn PJ, Creyghton MP, Bernards R. Protein phosphatase 2A regulatory subunits and cancer. Biochim Biophys Acta. 2009; 1795:1-15.10.1016/j.bbcan.2008.05.00518588945]Search in Google Scholar
[8. Nakada N, Kuroda K, Kawahara E. Protein phosphatase 2A regulatory subunit Bbeta promotes MAP kinase-mediated migration of A431 cells. Cell Physiol Biochem. 2005; 15:19-28.10.1159/00008363515665512]Search in Google Scholar
[9. Goodarzi AA, Jonnalagadda JC, Douglas P, Young D, Ye R, Moorhead GB, et al. Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. Embo J. 2004; 23:4451-61.10.1038/sj.emboj.760045552647015510216]Open DOISearch in Google Scholar
[10. Guo CY, Brautigan DL, Larner JM. ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation. J Biol Chem. 2002; 277:4839-44.10.1074/jbc.M11009220011723136]Search in Google Scholar
[11. Holmes SE, O’Hearn EE, McInnis MG, Gorelick- Feldman DA, Kleiderlein JJ, Callahan C, et al. Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12. Nat Genet.1999; 23:391-2.10.1038/70493]Open DOISearch in Google Scholar
[12. Holmes SE, O’Hearn E, Margolis RL. Why is SCA12 different from other SCAs? Cytogenet Genome Res. 2003; 100:189-97.10.1159/000072854]Open DOISearch in Google Scholar
[13. Chun HH, Gatti RA. Ataxia-telangiectasia, an evolving phenotype. DNA Repair (Amst). 2004; 3: 1187-96.10.1016/j.dnarep.2004.04.010]Search in Google Scholar
[14. Strack S, Zaucha JA, Ebner FF, Colbran RJ, Wadzinski BE. Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits. J Comp Neurol.1998; 392: 515-27.10.1002/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3]Search in Google Scholar
[15. Cardinali M, Pietraszkiewicz H, Ensley JF, Robbins KC. Tyrosine phosphorylation as a marker for aberrantly regulated growth-promoting pathways in cell lines derived from head and neck malignancies. Int J Cancer. 1995; 61:98-103.10.1002/ijc.2910610117]Search in Google Scholar
[16. Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, et al. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia. 2004; 6:1-6.10.1016/S1476-5586(04)80047-2]Open DOISearch in Google Scholar
[17. Fan CY. Genetic alterations in head and neck cancer: interactions among environmental carcinogens, cell cycle control, and host DNA repair. Curr Oncol Rep. 2001; 3:66-71.10.1007/s11912-001-0045-0]Open DOISearch in Google Scholar
[18. Wiseman SM, Stoler DL, Anderson GR. The role of genomic instability in the pathogenesis of squamous cell carcinoma of the head and neck. Surg Oncol Clin N Am. 2004; 13:1-11.10.1016/S1055-3207(03)00118-2]Open DOISearch in Google Scholar
[19. Richards KL, Zhang B, Baggerly KA, Colella S, Lang JC, Schuller DE, et al. Genome-wide hypomethylation in head and neck cancer is more pronounced in HPVnegative tumors and is associated with genomic instability. PLoS One. 2009; 4:e4941.10.1371/journal.pone.0004941]Search in Google Scholar
[20. Subbalekha K, Pimkhaokham A, Pavasant P, Chindavijak S, Phokaew C, Shuangshoti S, et al. Detection of LINE-1s hypomethylation in oral rinses of oral squamous cell carcinoma patients. Oral Oncol. 2009; 45:184-91.10.1016/j.oraloncology.2008.05.002]Search in Google Scholar
[21. Ginos MA, Page GP, Michalowicz BS, Patel KJ, Volker SE, Pambuccian SE, et al. Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res. 2004; 64:55-63.10.1158/0008-5472.CAN-03-2144]Open DOISearch in Google Scholar
[22. Pyeon D, Newton MA, Lambert PF, den Boon JA, Sengupta S, Marsit CJ, et al. Fundamental differences in cell cycle deregulation in human papillomaviruspositive and human papillomavirus-negative head/neck and cervical cancers. Cancer Res. 2007; 67: 4605-19.10.1158/0008-5472.CAN-06-3619]Search in Google Scholar
[23. Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 2003; 421:499-506.10.1038/nature01368]Search in Google Scholar
[24. Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem. 2001; 276: 42462-7.10.1074/jbc.C100466200]Search in Google Scholar
[25. Yeudall WA, Jakus J, Ensley JF, Robbins KC. Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck. Mol Carcinog. 1997; 18:89-96.10.1002/(SICI)1098-2744(199702)18:2<89::AID-MC4>3.0.CO;2-L]Search in Google Scholar
[26. Young DB, Jonnalagadda J, Gatei M, Jans DA, Meyn S, Khanna KK. Identification of domains of ataxiatelangiectasia mutated required for nuclear localization and chromatin association. J Biol Chem. 2005; 280: 27587-94.10.1074/jbc.M411689200]Search in Google Scholar
[27. Kim YC, Gerlitz G, Furusawa T, Catez F, Nussenzweig A, Oh KS, et al. Activation of ATM depends on chromatin interactions occurring before induction of DNA damage. Nat Cell Biol. 2009; 11:92-6.10.1038/ncb1817]Search in Google Scholar
[28. Kurz EU, Lees-Miller SP. DNA damage-induced activation of ATM and ATM-dependent signaling pathways. DNA Repair (Amst). 2004; 3:889-900.10.1016/j.dnarep.2004.03.029]Open DOISearch in Google Scholar
[29. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer. 2003; 3:155-68.10.1038/nrc1011]Open DOISearch in Google Scholar
[30. Huang Y, Sen T, Nagpal J, Upadhyay S, Trink B, Ratovitski E, et al. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell cells upon DNA damage. Cell Cycle. 2008; 7:2846-55.10.4161/cc.7.18.6627]Search in Google Scholar
[31. Meyn MS. Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene. Clin Genet. 1999; 55: 289-304.10.1034/j.1399-0004.1999.550501.x10422797]Open DOISearch in Google Scholar
[32. Garcia MJ, Benitez J. The Fanconi anaemia/BRCA pathway and cancer susceptibility. Searching for new therapeutic targets. Clin Transl Oncol. 2008; 10:78-84.10.1007/s12094-008-0160-618258506]Search in Google Scholar
[33. Parikh RA, White JS, Huang X, Schoppy DW, Baysal BE, Baskaran R, et al. Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma. Genes Chromosomes Cancer. 2007; 46:761-75.10.1002/gcc.2046217492757]Search in Google Scholar
[34. Bolt J, Vo QN, Kim WJ, McWhorter AJ, Thomson J, Hagensee ME, et al. The ATM/p53 pathway is commonly targeted for inactivation in squamous cell carcinoma of the head and neck (SCCHN) by multiple molecular mechanisms. Oral Oncol. 2005; 41:1013-20.10.1016/j.oraloncology.2005.06.00316139561]Search in Google Scholar
[35. Ai L, Vo QN, Zuo C, Li L, Ling W, Suen JY, et al. Ataxia-telangiectasia-mutated (ATM) gene in head and neck squamous cell carcinoma: promoter hypermethylation with clinical correlation in 100 cases. Cancer Epidemiol Biomarkers Prev. 2004; 13:150-6.10.1158/1055-9965.EPI-082-3]Open DOISearch in Google Scholar
[36. Kim WJ, Vo QN, Shrivastav M, Lataxes TA, Brown KD. Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line. Oncogene. 2002; 21:3864-71.10.1038/sj.onc.120548512032824]Open DOISearch in Google Scholar
[37. Roy K, Wang L, Makrigiorgos GM, Price BD. Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity. Biochem Biophys Res Commun. 2006; 344:821-6.10.1016/j.bbrc.2006.03.22216631604]Search in Google Scholar
[38. Zou J, Qiao X, Ye H, Yang Y, Zheng X, Zhao H, et al. Antisense inhibition of ATM gene enhances the radiosensitivity of head and neck squamous cell carcinoma in mice. J Exp Clin Cancer Res. 2008; 27:56.10.1186/1756-9966-27-56258400318950535]Search in Google Scholar
[39. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem. 1998; 273:5858-68.10.1074/jbc.273.10.58589488723]Search in Google Scholar
[40. Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S, et al. GammaH2AX and cancer. Nat Rev Cancer. 2008; 8:957-67.10.1038/nrc2523309485619005492]Search in Google Scholar
[41. Kuo LJ, Yang LX. Gamma-H2AX - a novel biomarker for DNA double-strand breaks. In Vivo. 2008; 22:305-9.]Search in Google Scholar
[42. Krauss S, Foerster J, Schneider R, Schweiger S. Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3. Cancer Res. 2008; 68:4658-65.10.1158/0008-5472.CAN-07-617418559511]Open DOISearch in Google Scholar