<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Chlamydiae are Gram-negative, non-motile, obligate intracellular, and spherically shaped bacteria with a diameter of 0.2-1.5 μm. Chlamydiae are present in several different morphological forms: the elementary body, the reticular body, and in the last several years, there has been the observation of a third form known as the persistent or atypical form. The intracellular localization of Chlamydia provides a unique replication cycle that occurs inside a membrane-surrounded vacuole in the host cell cytoplasm and is significantly different from the method of multiplication of other microorganisms. Chlamydiae are capable of manipulating different signalling pathways inside the infected cell, thus avoiding the host immune response. This ensures intracellular multiplication, survival, and long-term persistence of Chlamydiae. There are two basic means of achieving this persistence: inhibition of apoptosis and manipulation of NF-κB (nuclear factor kappa B)-mediated signals in the host.</p></abstract>

Chlamydiae are Gram-negative, non-motile, obligate intracellular, and spherically shaped bacteria with a diameter of 0.2-1.5 μm. Chlamydiae are present in several different morphological forms: the elementary body, the reticular body, and in the last several years, there has been the observation of a third form known as the persistent or atypical form. The intracellular localization of Chlamydia provides a unique replication cycle that occurs inside a membrane-surrounded vacuole in the host cell cytoplasm and is significantly different from the method of multiplication of other microorganisms. Chlamydiae are capable of manipulating different signalling pathways inside the infected cell, thus avoiding the host immune response. This ensures intracellular multiplication, survival, and long-term persistence of Chlamydiae. There are two basic means of achieving this persistence: inhibition of apoptosis and manipulation of NF-κB (nuclear factor kappa B)-mediated signals in the host.

Mechanisms of Intracellular Chlamydiae Survival

Department of Microbiology, Faculty of Medicine Foca, University of East Sarajevo, Republic of Srpska, Bosnia and Herzegovina

Department of Microbiology, Clinical Center of Serbia, Belgrade, Serbia

Center for Molecular Medicine and Stem Cell Research Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia

Department of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Mechanisms of Intracellular Chlamydiae Survival"}

Chlamydiae are Gram-negative, non-motile, obligate intracellular, and spherically shaped bacteria with a diameter of 0.2-1.5 μm. Chlamydiae are present in...

Mechanisms of Intracellular Chlamydiae Survival

Publicado en línea: 10 jun 2016

Páginas: 145 - 152

Recibido: 28 dic 2015

Aceptado: 09 ene 2016

DOI: https://doi.org/10.1515/sjecr-2016-0010

Palabras clave
Chlamydia, invasion, inclusion, intracellular survival, persistence

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mechanisms of Intracellular Chlamydiae Survival

Publicado en línea: 10 jun 2016

Páginas: 145 - 152

Recibido: 28 dic 2015

Aceptado: 09 ene 2016

DOI: https://doi.org/10.1515/sjecr-2016-0010

Palabras claveChlamydia, invasion, inclusion, intracellular survival, persistence

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Palabras clave
Chlamydia, invasion, inclusion, intracellular survival, persistence