<abstract xmlns="http://www.w3.org/1999/xhtml"><p>An animal model of human behavior represents a complex of cognitive and/or emotional processess, which are translated from animals to humans. A behavioral test is developed primarily and specifically to verify and support a theory of cognition or emotion; it can also be used to verify a theory of a psychopathology, but it is not developed for a particular type of psychopathology. The paper reviews tests commonly used in novel drug discovery research. Focus is especially on tests which can evaluate anxiety-like (open-field test, novelty suppressed feeding, elevated plus maze, light/dark box, stressinduced hyperthermia) and depression-like behaviors (forced swim test, tail suspension test, sucrose preference test) as they represent an important methodological tool in pre-clinical as well as in behavioral toxicology studies.</p></abstract>

An animal model of human behavior represents a complex of cognitive and/or emotional processess, which are translated from animals to humans. A behavioral test is developed primarily and specifically to verify and support a theory of cognition or emotion; it can also be used to verify a theory of a psychopathology, but it is not developed for a particular type of psychopathology. The paper reviews tests commonly used in novel drug discovery research. Focus is especially on tests which can evaluate anxiety-like (open-field test, novelty suppressed feeding, elevated plus maze, light/dark box, stressinduced hyperthermia) and depression-like behaviors (forced swim test, tail suspension test, sucrose preference test) as they represent an important methodological tool in pre-clinical as well as in behavioral toxicology studies.

Animal tests for anxiety-like and depression-like behavior in rats

Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences

Department of Pharmacology, Jessenius Faculty of Medicine

Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Animal tests for anxiety-like and depression-like behavior in rats"}

An animal model of human behavior represents a complex of cognitive and/or emotional processess, which are translated from animals to humans. A behavioral test...

Animal tests for anxiety-like and depression-like behavior in rats

Publicado en línea: 14 feb 2018

Páginas: 40 - 43

Recibido: 10 mar 2017

Aceptado: 25 abr 2017

DOI: https://doi.org/10.1515/intox-2017-0006

Palabras clave
behavior, rat, anxiety, depression, tests

© 2017 Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Animal tests for anxiety-like and depression-like behavior in rats

Publicado en línea: 14 feb 2018

Páginas: 40 - 43

Recibido: 10 mar 2017

Aceptado: 25 abr 2017

DOI: https://doi.org/10.1515/intox-2017-0006

Palabras clavebehavior, rat, anxiety, depression, tests

© 2017 Interdisciplinary Toxicology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Palabras clave
behavior, rat, anxiety, depression, tests