<abstract xmlns="http://www.w3.org/1999/xhtml"><p>A new HPLC method was introduced and validated for simultaneous determination of perindopril and indapamide. Validation procedure included specificity, sensitivity, robustness, stability, linearity, precision and accuracy. The method was used for the dissolution test of perindopril and indapamide in three fixed-dose formulations. The dissolution procedure was optimized using different media, different pH of the buffer, surfactants, paddle speed and temperature. Similarity of dissolution profiles was estimated using different model-independent and model-dependent methods and, additionally, by principal component analysis (PCA). Also, some kinetic models were checked for dissolved amounts of drugs as a function of time.</p></abstract>

A new HPLC method was introduced and validated for simultaneous determination of perindopril and indapamide. Validation procedure included specificity, sensitivity, robustness, stability, linearity, precision and accuracy. The method was used for the dissolution test of perindopril and indapamide in three fixed-dose formulations. The dissolution procedure was optimized using different media, different pH of the buffer, surfactants, paddle speed and temperature. Similarity of dissolution profiles was estimated using different model-independent and model-dependent methods and, additionally, by principal component analysis (PCA). Also, some kinetic models were checked for dissolved amounts of drugs as a function of time.

Dissolution profiles of perindopril and indapamide in their fixed-dose formulations by a new HPLC method and different mathematical approaches

Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University in Lublin, 20-090 Lublin, Poland

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A new HPLC method was introduced and validated for simultaneous determination of perindopril and indapamide. Validation procedure included specificity,...

Dissolution profiles of perindopril and indapamide in their fixed-dose formulations by a new HPLC method and different mathematical approaches

Publicado en línea: 30 sept 2015

Páginas: 235 - 252

Aceptado: 14 may 2015

DOI: https://doi.org/10.1515/acph-2015-0024

Palabras clave
perindopril, indapamide, dissolution profiles, model-independent methods, model-dependent methods, PCA

© Anna Gumieniczek et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Dissolution profiles of perindopril and indapamide in their fixed-dose formulations by a new HPLC method and different mathematical approaches

Publicado en línea: 30 sept 2015

Páginas: 235 - 252

Aceptado: 14 may 2015

DOI: https://doi.org/10.1515/acph-2015-0024

Palabras claveperindopril, indapamide, dissolution profiles, model-independent methods, model-dependent methods, PCA

© Anna Gumieniczek et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
perindopril, indapamide, dissolution profiles, model-independent methods, model-dependent methods, PCA