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Status of circulating bone turnover markers in elderly osteoporosis/osteopenia patients in comparison with healthy subjects

Sadra Samavarchi Tehrani
Sadra Samavarchi Tehrani
, 
Maryam Moallem
Maryam Moallem
, 
Reyhane Ebrahimi
Reyhane Ebrahimi
, 
Seyed Reza Hosseini
Seyed Reza Hosseini
, 
Hajighorban Nooreddini
Hajighorban Nooreddini
 y 
Hadi Parsian
Hadi Parsian
   | 10 sept 2020
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Article Category: Original article
Publicado en línea: 10 sept 2020
Páginas: 97 - 106
DOI: https://doi.org/10.1515/abm-2020-0015
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© 2020 Sadra Samavarchi Tehrani et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Correlation analysis results between analyzed biochemical parameters in included groups in this study. A: normal group, B: osteopenia group, C: osteoporosis group. A positive correlation between the progesterone levels with ICTP and spinal BMD (r = 0.47, P = 0.01 and r = 0.42, P = 0.027, respectively), as well as B-ALP with estrogen was also observed (r = 0.7, P = 0.001) in healthy individuals. Progesterone was positively correlated with femoral BMD (r = 0.437, P = 0.02) in osteopenic patients. NTX was negatively correlated with estrogen in osteoporotic patients (r = –0.4, P = 0.036). ICTP, C-terminal telopeptide of type I collagen; BMD, bone mineral density; B-ALP, bone alkaline phosphatase; BMD-F and BMD-S, bone mineral density of femur and spine; B-ALP, bone alkaline phosphatase; PINP, procollagen type I N-terminal propeptide; NTX, amino-terminal cross-linked telopeptide of type I collagen; ROC, receiver operating characteristics.
Correlation analysis results between analyzed biochemical parameters in included groups in this study. A: normal group, B: osteopenia group, C: osteoporosis group. A positive correlation between the progesterone levels with ICTP and spinal BMD (r = 0.47, P = 0.01 and r = 0.42, P = 0.027, respectively), as well as B-ALP with estrogen was also observed (r = 0.7, P = 0.001) in healthy individuals. Progesterone was positively correlated with femoral BMD (r = 0.437, P = 0.02) in osteopenic patients. NTX was negatively correlated with estrogen in osteoporotic patients (r = –0.4, P = 0.036). ICTP, C-terminal telopeptide of type I collagen; BMD, bone mineral density; B-ALP, bone alkaline phosphatase; BMD-F and BMD-S, bone mineral density of femur and spine; B-ALP, bone alkaline phosphatase; PINP, procollagen type I N-terminal propeptide; NTX, amino-terminal cross-linked telopeptide of type I collagen; ROC, receiver operating characteristics.

Figure 2

Comparison of diagnostic accuracies of biochemical parameters by ROC curve analysis discriminate for patient groups (osteoporosis and osteopenia) and the healthy subjects. C.PINP, procollagen type I N-terminal propeptide; C.NTX, amino-terminal cross-linked telopeptide of type I collagen; C.BALP, bone alkaline phosphatase.
Comparison of diagnostic accuracies of biochemical parameters by ROC curve analysis discriminate for patient groups (osteoporosis and osteopenia) and the healthy subjects. C.PINP, procollagen type I N-terminal propeptide; C.NTX, amino-terminal cross-linked telopeptide of type I collagen; C.BALP, bone alkaline phosphatase.

Figure 3

Comparison of diagnostic accuracies of biochemical parameters by ROC curve analysis for discrimination of the healthy persons versus osteoporosis patients. C.PINP, procollagen type I N-terminal propeptide; C.NTX, amino-terminal cross-linked telopeptide of type I collagen; C.BALP, bone alkaline phosphatase.
Comparison of diagnostic accuracies of biochemical parameters by ROC curve analysis for discrimination of the healthy persons versus osteoporosis patients. C.PINP, procollagen type I N-terminal propeptide; C.NTX, amino-terminal cross-linked telopeptide of type I collagen; C.BALP, bone alkaline phosphatase.

Figure 4

Comparison of diagnostic accuracies of biochemical parameters by ROC curve analysis for discrimination of the healthy persons versus osteopenic patients. C.PINP, procollagen type I N-terminal propeptide; C.NTX, amino-terminal cross-linked telopeptide of type I collagen; C.BALP, bone alkaline phosphatase.
Comparison of diagnostic accuracies of biochemical parameters by ROC curve analysis for discrimination of the healthy persons versus osteopenic patients. C.PINP, procollagen type I N-terminal propeptide; C.NTX, amino-terminal cross-linked telopeptide of type I collagen; C.BALP, bone alkaline phosphatase.

Comparison of mean values of clinical and biochemical parameters between included persons in this study

ParametersHealthy persons (mean ± SD)Osteopenia (mean ± SD)Osteoporosis (mean ± SD)P
BMD-S (g/cm2)1.12 ± 0.130.85 ± 0.030.63 ± 0.08<0.001
BMD-F (g/cm2)1.06 ± 0.110.84 ± 0.050.65 ± 0.08<0.001
Age65.61 ± 5.1166.32 ± 5.2168.07 ± 5.460.11
Estrogen (pg/ml)79.6 ± 42.9668.10 ± 13.9166.53 ± 32.400.183
Progesterone (ng/ml)0.11 ± 0.220.12 ± 0.210.13 ± 0.420.547
ICTP (ng/ml)438.2 ± 209.81409.7 ± 177.3396.8 ± 197.530.736
PINP (pg/ml)57.1 ± 17.5357.13 ± 12.6668.5 ± 12.960.003
NTX (nmol BCE/L)15.5 ± 11.7121.1 ± 12.0319.06 ± 11.330.089
B-ALP (ng/ml)3.40 ± 4.725.90 ± 4.585.91 ± 5.170.009

Comparison of diagnostic accuracies of biochemical parameters by ROC analysis for discrimination of the healthy persons than the two other groups

ParametersAUC (CI)PCutoff pointSenSpPPVNPVLR+LR−
NTX (nmol BCE/L)
Normal vs osteoporosis0.63 (0.48–0.78)0.09013.57756165701.920.40
Normal vs osteopenia0.65 (0.5–0.79)0.05013.91716164681.160.47
Normal vs patient0.64 (0.51–0.77)0.03613.57736178532.510.44
B-ALP (ng/ml)
Normal vs osteoporosis0.72 (0.58–0.86)0.0052.10825463751.780.33
Normal vs osteopenia0.71 (0.55–0.84)0.0123.23717574722.840.38
Normal vs patient0.70 (0.59–0.83)0.0023.03706881542.180.44
PINP (pg/ml)
Normal vs osteoporosis0.71 (0.57–0.85)0.00762.12716567702.020.44
Normal vs osteopenia0.49 (0.34–0.65)0.98746.00853355691.260.45
Normal vs patients0.58 (0.471–0.738)0.12158.85585873411.320.72
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