Published Online: Nov 13, 2012
Page range: 115 - 130
DOI: https://doi.org/10.2478/v10127-012-0012-1
Keywords
This content is open access.
We provide some details of the implementation of optimal design algorithm in the PkStaMp library which is intended for constructing optimal sampling schemes for pharmacokinetic (PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of individual Fisher information matrix and describe a user-defined option of the library.