<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: Burkholderia pseudomallei are causative agents of melioidosis, a disease found mostly in South- East Asia and Northern Australia. Recent reports of a reduced susceptibility of B. pseudomallei to antibiotics, especially ceftazidime, have indicated need for further research into new antimicrobial substances from plants. Objectives: We tested antimicrobial activity of 10 plant extracts; Barringtonia acutangula (L.) Gaertn., Cleome gynandra Linn., Luffa acutangula (Linn.) Roxb., Limnophila geoffrayi Bonati, Centella asiatica (L.) Urban, Piper sarmentosum Roxb., Tamarindus indica, Cyperus rotundus Linn., Cassia fistula Linn., and Allium sativum Linn. Materials and Methods: Crude extracts were tested for their antimicrobial activity by the standard disc diffusion assay and micro-dilution assay. Methanol, ethyl acetate, ethanol, hexane, and water were used as solvents for extraction. Results: The methanolic extract of B. acutangula (L.) Gaertn. showed the best antimicrobial results against B. pseudomallei with an inhibition zone of 18 mm and minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of 4 mg/ml. The chemical structure of crude methanolic extracts of B. acutangula (L.) Gaertn. was primarily elucidated by nuclear magnetic resonance spectroscopy (NMR). The results showed that the chemical constituent was in the group of steroids. Conclusions: It is concluded that Barringtonia acutangula (L.) Gaertn. may play an active part in the inhibition of the growth of B. pseudomallei.</abstract>

Background: Burkholderia pseudomallei are causative agents of melioidosis, a disease found mostly in South- East Asia and Northern Australia. Recent reports of a reduced susceptibility of B. pseudomallei to antibiotics, especially ceftazidime, have indicated need for further research into new antimicrobial substances from plants. Objectives: We tested antimicrobial activity of 10 plant extracts; Barringtonia acutangula (L.) Gaertn., Cleome gynandra Linn., Luffa acutangula (Linn.) Roxb., Limnophila geoffrayi Bonati, Centella asiatica (L.) Urban, Piper sarmentosum Roxb., Tamarindus indica, Cyperus rotundus Linn., Cassia fistula Linn., and Allium sativum Linn. Materials and Methods: Crude extracts were tested for their antimicrobial activity by the standard disc diffusion assay and micro-dilution assay. Methanol, ethyl acetate, ethanol, hexane, and water were used as solvents for extraction. Results: The methanolic extract of B. acutangula (L.) Gaertn. showed the best antimicrobial results against B. pseudomallei with an inhibition zone of 18 mm and minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of 4 mg/ml. The chemical structure of crude methanolic extracts of B. acutangula (L.) Gaertn. was primarily elucidated by nuclear magnetic resonance spectroscopy (NMR). The results showed that the chemical constituent was in the group of steroids. Conclusions: It is concluded that Barringtonia acutangula (L.) Gaertn. may play an active part in the inhibition of the growth of B. pseudomallei.

Bioactivity of plant extracts against Burkholderia pseudomallei

College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani 34190,

Department of Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani 34190,

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Bioactivity of plant extracts against Burkholderia pseudomallei"}

Background: Burkholderia pseudomallei are causative agents of melioidosis, a disease found mostly in South- East Asia and Northern Australia. Recent reports of...

Bioactivity of plant extracts against Burkholderia pseudomallei

Article Category: Brief communication (Original)

Online veröffentlicht: 04. Feb. 2017

Seitenbereich: 619 - 623

DOI: https://doi.org/10.5372/1905-7415.0604.100

Schlüsselwörter
Antimicrobial activity, B. pseudomallei, disc diffusion, plant extracts

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Bioactivity of plant extracts against Burkholderia pseudomallei

Article Category: Brief communication (Original)

Online veröffentlicht: 04. Feb. 2017

Seitenbereich: 619 - 623

DOI: https://doi.org/10.5372/1905-7415.0604.100

SchlüsselwörterAntimicrobial activity, B. pseudomallei, disc diffusion, plant extracts

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Schlüsselwörter
Antimicrobial activity, B. pseudomallei, disc diffusion, plant extracts