<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>An asymmetric membrane capsule of cellulose acetate for osmotic delivery of flurbiprofen has been developed and influence of osmogents and solubilizing agent on <italic>in vitro</italic> drug release were evaluated. The capsule membrane was prepared by the phase inversion technique. To ensure the osmotic delivery of drug, two approaches were adopted: (<italic>i</italic>) the drug was encapsulated with osmogents like sodium chloride and mannitol to increase the osmotic pressure of the core, and (<italic>ii</italic>) the drug was encapsulated with sodium lauryl sulfate in the core of the formulation to increase the solubility and thus its osmotic pressure. Scanning electron microscopy of the membrane confirmed its porous, dense asymmetric nature. Dye test revealed <italic>in situ</italic> pore formation. The <italic>in vitro</italic> release study showed that as the proportion of osmogent and solubilizing agent was increased the release rate also increased. A good correlation was observed between the zero-order rate constant and the amount of the osmogent and solubilizing agent used.</p></abstract>

An asymmetric membrane capsule of cellulose acetate for osmotic delivery of flurbiprofen has been developed and influence of osmogents and solubilizing agent on in vitro drug release were evaluated. The capsule membrane was prepared by the phase inversion technique. To ensure the osmotic delivery of drug, two approaches were adopted: (i) the drug was encapsulated with osmogents like sodium chloride and mannitol to increase the osmotic pressure of the core, and (ii) the drug was encapsulated with sodium lauryl sulfate in the core of the formulation to increase the solubility and thus its osmotic pressure. Scanning electron microscopy of the membrane confirmed its porous, dense asymmetric nature. Dye test revealed in situ pore formation. The in vitro release study showed that as the proportion of osmogent and solubilizing agent was increased the release rate also increased. A good correlation was observed between the zero-order rate constant and the amount of the osmogent and solubilizing agent used.

Asymmetric membrane capsule for osmotic delivery of flurbiprofen

Department of Pharmacy, Fiji School of Medicine, Suva, Fiji Islands

Department of Pharmaceutics, B. N. College of Pharmacy, Udaipur, Rajasthan, India

Department of Pharmacy, Mohan Lal Sukhadia University, Udaipur, Rajasthan, India

Acta Pharmaceutica

{"article-title":"Asymmetric membrane capsule for osmotic delivery of flurbiprofen"}

An asymmetric membrane capsule of cellulose acetate for osmotic delivery of flurbiprofen has been developed and influence of osmogents and solubilizing agent...

Asymmetric membrane capsule for osmotic delivery of flurbiprofen

Online veröffentlicht: 18. Sept. 2007

Seitenbereich: 343 - 350

DOI: https://doi.org/10.2478/v10007-007-0027-3

Schlüsselwörter
osmotic delivery, asymmetric membrane, cellulose acetate, flurbiprofen, osmogent

This content is open access.

Asymmetric membrane capsule for osmotic delivery of flurbiprofen

Online veröffentlicht: 18. Sept. 2007

Seitenbereich: 343 - 350

DOI: https://doi.org/10.2478/v10007-007-0027-3

Schlüsselwörterosmotic delivery, asymmetric membrane, cellulose acetate, flurbiprofen, osmogent

This content is open access.

Schlüsselwörter
osmotic delivery, asymmetric membrane, cellulose acetate, flurbiprofen, osmogent